Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Mehdi Goudarzi 1 , 2 , Mojtaba Kalantar 3 and Hadi Kalantar 2 , *
Authors Information
1 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: November 2017, 12 (4); e12345
  • Published Online: November 26, 2017
  • Article Type: Research Article
  • Received: May 9, 2017
  • Accepted: May 14, 2017
  • DOI: 10.5812/jjnpp.12345

To Cite: Goudarzi M, Kalantar M, Kalantar H. The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats, Jundishapur J Nat Pharm Prod. 2017 ; 12(4):e12345. doi: 10.5812/jjnpp.12345.

Copyright © 2017, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Von Burg R. Inorganic mercury. J Appl Toxicol. 1995;15(6):483-93. [PubMed: 8603936].
  • 2. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70-7. [PubMed: 13650640].
  • 3. Celikoglu E, Aslanturk A, Kalender Y. Vitamin E and sodium selenite against mercuric chloride induced lung toxicity in the rats. Braz Arch Biol Technol. 2015;58(4):587-94. doi: 10.1590/s1516-8913201500098.
  • 4. Jafari M, Rezaei M, Kalantari H, Hashemitabar M. Determination of Cell Death Induced by Lovastatin on Human Colon Cell Line HT29 Using the Comet Assay. Jundishapur J Nat Pharm Prod. 2013;8:187-91.
  • 5. Argentieri M, Macchia F, Papadia P, Fanizzi FP, Avato P. Bioactive compounds from Capparis spinosa subsp, rupestris. Ind Crops Prod. 2012;36(1):65-9. doi: 10.1016/j.indcrop.2011.08.007.
  • 6. Bash B. Hepatoprotective and hypolipidemic effects of Spirulina platensis in rats administered mercuric chloride. Afr J Pharm Pharmacol. 2011;5(2):175-82. doi: 10.5897/ajmr10.330.
  • 7. Mahboob M, Shireen KF, Atkinson A, Khan AT. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J Environ Sci Health B. 2001;36(5):687-97. doi: 10.1081/PFC-100106195. [PubMed: 11599730].
  • 8. Mazzachi BC, Peake MJ, Ehrhardt V. Reference range and method comparison studies for enzymatic and Jaffe creatinine assays in plasma and serum and early morning urine. Clin Lab. 2000;46(1-2):53-5. [PubMed: 10745982].
  • 9. Miller DM, Lund BO, Woods JS. Reactivity of Hg(II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg(II). J Biochem Toxicol. 1991;6(4):293-8. [PubMed: 1663557].
  • 10. Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res. 2008;128(4):501-23. [PubMed: 19106443].
  • 11. Magos L, Clarkson TW. Overview of the clinical toxicity of mercury. Ann Clin Biochem. 2006;43(Pt 4):257-68. doi: 10.1258/000456306777695654. [PubMed: 16824275].
  • 12. Necib Y, Bahi A, Zerizer S. Amelioration of mercuric chloride toxicity on rat liver with argan oil and sodium selenite supplements. Int J Pharm Bio Sci. 2013;4(2):839-49.
  • 13. Youcef N, Ahlem B, Sakina Z. Protective role of sodium selenite on mercuric chloride induced oxidative and renal stress in rats. J Stress Physiol Biochem. 2013;9(2).
  • 14. Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med. 1995;18(2):321-36. [PubMed: 7744317].
  • 15. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011;283(2-3):65-87. doi: 10.1016/j.tox.2011.03.001. [PubMed: 21414382].
  • 16. Goudarzi M, Kalantar M, Kalantari H. Protective effect of hydroalcoholic extract of Lavandula officinalis L. on gentamicin induced nephrotoxicity in rats. Toxicol Lett. 2016;258:284-5. doi: 10.1016/j.toxlet.2016.06.1991.
  • 17. Kalantar M, Houshmand G, Kalantar H, Asadi M, Goudarzi M. Protective effect of hydroalcoholic extract of Lavandula officinalis L. on gentamicin induced nephrotoxicity in rats. J Babol Univ Med Sci. 2016;18(7):62-7.
  • 18. Singh J, Rai G, Upadhyay A, Kumar R, Singh K. Antloxldant phytochemicals in tomato, (Lycopersicon esculentum). Indian J Agric Sci. 2004;74(1):3-5.
  • 19. Moosavi M, Rezaei M, Kalantari H, Behfar A, Varnaseri G. l-carnitine protects rat hepatocytes from oxidative stress induced by T-2 toxin. Drug Chem Toxicol. 2016;39(4):445-50. doi: 10.3109/01480545.2016.1141423. [PubMed: 26888052].
  • 20. Melikian AA, Qu Q,, Shore R, Li G, Li H, Jin X, et al. Personal exposure to different levels of benzene and its relationships to the urinary metabolites S phenylmercapturic acid and trans, trans muconic acid. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;778(1):211-21. [PubMed: 12376128].
  • 21. Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6 hydroxydopamine in rats. Food Chem. 2013;138(2):1028-33. doi: 10.1016/j.foodchem.2012.11.022. [PubMed: 23411210].
  • 22. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54. [PubMed: 942051].
  • 23. Shahbazzadeh D, Amirkhani A, Djadid ND, Bigdeli S, Akbari A, Ahari H, et al. Epidemiological and clinical survey of scorpionism in Khuzestan province, Iran (2003). Toxicon. 2009;53(4):454-9. doi: 10.1016/j.toxicon.2009.01.002. [PubMed: 19708123].
  • 24. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56-63. [PubMed: 13458125].
  • 25. Belfield A, Goldberg DM. Colorimetric determination of alkaline phosphatase activity. Enzyme. 1971;12(5):561-8.
  • 26. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302-10. [PubMed: 672633].
  • 27. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6. [PubMed: 6727660].
  • 28. Martin JJ, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys. 1987;255(2):329-36. [PubMed: 3036004].
  • 29. Patel TA, Rao MV. Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes. Drug Chem Toxicol. 2015;38(4):408-14. doi: 10.3109/01480545.2014.975354. [PubMed: 25645230].
  • 30. Bridges CC, Joshee L, Zalups RK. Aging and the disposition and toxicity of mercury in rats. Exp Gerontol. 2014;53:31-9. doi: 10.1016/j.exger.2014.02.006. [PubMed: 24548775].
  • 31. Madureira P, Cunha EM, Aguas AP. Acute depletion and recovery of peritoneal B-1 lymphocytes in BALB/c mice after a single injection of mercury chloride. Immunopharmacol Immunotoxicol. 2007;29(2):311-22. doi: 10.1080/08923970701513518. [PubMed: 17849274].
  • 32. Bharathi E, Jagadeesan G, Vijayakumar M. Hepato ameliorative effect of hesperidin and ellagic acid on mercuric chloride intoxicated rats. Biomed Aging Pathol. 2014;4(1):17-21. doi: 10.1016/j.biomag.2013.10.002.
  • 33. Bashandy SA, El Awdan SA, Ebaid H, Alhazza IM. Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats. Oxid Med Cell Longev. 2016;2016:7174351. doi: 10.1155/2016/7174351. [PubMed: 26881036].
  • 34. Hwang JM, Wang CJ, Chou FP, Tseng TH, Hsieh YS, Lin WL, et al. Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver. Arch Toxicol. 2002;76(11):664-70. doi: 10.1007/s00204-002-0351-9. [PubMed: 12415430].
  • 35. Kalantari H, Nazari Z, Keliddar A, Foruozandeh H, Kalantar M. Study of the protective effect of livergol against liver toxicity caused by bromobenzene in mice. Iran J Pharm Sci. 2015;10(2):11-20.
  • 36. Nwokocha C, Ejebe D, Nwangwa E, Ekene N, Akonoghrere R, Ukwu J. The effects of bitter kola supplemented diet on hepatotoxicity of mercury in wistar rats. J Appl Sci Environ Manage. 2010;14(1). doi: 10.4314/jasem.v14i1.56506.
  • 37. Sheikh T, Patel B, Joshi D, Patel R, Jegoda M. Repeated dose oral toxicity of inorganic mercury in wistar rats, biochemical and morphological alterations. Vet World. 2013;6(8):563. doi: 10.5455/vetworld.2013.563-567.
  • 38. Nabavi SF, Nabavi SM, Habtemariam S, Moghaddam AH, Sureda A, Jafari M, et al. Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride induced oxidative stress. Ind Crops Prod. 2013;44:50-5. doi: 10.1016/j.indcrop.2012.10.024.
  • 39. Vijaya Padma V, Sowmya P, Arun Felix T, Baskaran R, Poornima P. Protective effect of gallic acid against lindane induced toxicity in experimental rats. Food Chem Toxicol. 2011;49(4):991-8. doi: 10.1016/j.fct.2011.01.005. [PubMed: 21219962].
  • 40. Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, et al. Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009;47(6):1385-92. doi: 10.1016/j.fct.2009.03.021. [PubMed: 19327382].
  • 41. Franciscato C, Moraes-Silva L, Duarte FA, Oliveira CS, Ineu RP, Flores EM, et al. Delayed biochemical changes induced by mercury intoxication are prevented by zinc pre-exposure. Ecotoxicol Environ Saf. 2011;74(3):480-6. doi: 10.1016/j.ecoenv.2010.11.011. [PubMed: 21183220].
  • 42. Kalantar H, Sabetkasaei M, Shahriari A, Haj Molla Hoseini M, Mansouri S, Kalantar M, et al. The effect of rapamycin on oxidative stress in MCF 7 and MDA MB 231 human breast cancer cell lines. Jundishapur J Nat Pharm Prod. 2016;11(3). doi: 10.17795/jjnpp-38177.
  • 43. Syversen T, Kaur P. The toxicology of mercury and its compounds. J Trace Elem Med Biol. 2012;26(4):215-26. doi: 10.1016/j.jtemb.2012.02.004. [PubMed: 22658719].
  • 44. Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, Goudarzi M. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomed Pharmacother. 2018;97:233-9. doi: 10.1016/j.biopha.2017.10.113. [PubMed: 29091871].
  • 45. Goudarzi M, Esmaeilizadeh M, Dolatshahi M, Kalantar H, Frouzandeh H, et al. Protective Effect of Elaeagnus angustifolia L. Fruit Hydroalcoholic Extract on Cyclophosphamide-Induced Nephrotoxicity in Mice. Shiraz E-Med J. 2018;19(1). 55075. doi: 10.5812/semj.55075.
  • 46. Tang LQ, Wei W, Chen LM, Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol. 2006;108(1):109-15. doi: 10.1016/j.jep.2006.04.019. [PubMed: 16759828].
  • 47. Kalantari H, Larki A, Latifi SM. The genotoxicity study of garlic and pasipay herbal drops by peripheral blood micronucleus test. Acta Physiol Hung. 2007;94(3):261-6. doi: 10.1556/APhysiol.94.2007.3.10.
  • 48. Polewski K, Kniat S, Slawinska D. Gallic acid, a natural antioxidant, in aqueous and micellar environment, spectroscopic studies. Curr Top Biophys. 2002;26:217-27.
  • 49. Kim YJ. Antimelanogenic and antioxidant properties of gallic acid. Biol Pharm Bull. 2007;30(6):1052-5. [PubMed: 17541153].
  • 50. Reckziegel P, Dias VT, Benvegnu DM, Boufleur N, Barcelos RCS, Segat HJ, et al. Antioxidant protection of gallic acid against toxicity induced by Pb in blood, liver and kidney of rats. Toxicol Rep. 2016;3:351-6. doi: 10.1016/j.toxrep.2016.02.005. [PubMed: 28959556].
  • 51. Punithavathi VR, Prince PS, Kumar R, Selvakumari J. Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats. Eur J Pharmacol. 2011;650(1):465-71. doi: 10.1016/j.ejphar.2010.08.059. [PubMed: 20863784].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments