Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Therapeutic Effect of Gallic Acid Against Paraquat-Induced Lung Injury in Rat

Mojtaba Kalantar 1 , 2 , Mohammad Javad Khodayar 2 , 3 , Heibatullah Kalantari 2 , 3 , Layasadat Khorsandi 4 and Ali Asghar Hemmati 5 , 6 , *
Authors Information
1 Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
2 Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Toxicology, Shool of Phamacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Cell and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6 Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2018, 13 (3); e12450
  • Published Online: January 1, 2018
  • Article Type: Research Article
  • Received: May 3, 2017
  • Revised: May 16, 2017
  • Accepted: May 23, 2017
  • DOI: 10.5812/jjnpp.12450

To Cite: Kalantar M, Khodayar M J, Kalantari H, Khorsandi L, Hemmati A A. Therapeutic Effect of Gallic Acid Against Paraquat-Induced Lung Injury in Rat, Jundishapur J Nat Pharm Prod. 2018 ; 13(3):e12450. doi: 10.5812/jjnpp.12450.

Copyright © 2017, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Chen D, Ma T, Liu XW, Yang C, Liu Z. Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFkappaB activation. Int J Clin Exp Pathol. 2015;8(5):4627-38. [PubMed: 26191153].
  • 2. Zhang J, Lv G, Zhao Y. The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans. Clin Biochem. 2011;44(2-3):221-5. doi: 10.1016/j.clinbiochem.2010.09.006. [PubMed: 20868655].
  • 3. Xiao ZW, Zhang W, Ma L, Qiu ZW. Therapeutic effect of magnesium isoglycyrrhizinate in rats on lung injury induced by paraquat poisoning. Eur Rev Med Pharmacol Sci. 2014;18(3):311-20. [PubMed: 24563429].
  • 4. Khodayar MJ, Kiani M, Hemmati AA, Rezaie A, Zerafatfard MR, Rashidi Nooshabadi MR, et al. The preventive effect of atorvastatin on paraquat-induced pulmonary fibrosis in the rats. Adv Pharm Bull. 2014;4(4):345-9. doi: 10.5681/apb.2014.050. [PubMed: 25436189].
  • 5. Guo F, Sun YB, Su L, Li S, Liu ZF, Li J, et al. Losartan attenuates paraquat-induced pulmonary fibrosis in rats. Hum Exp Toxicol. 2015;34(5):497-505. doi: 10.1177/0960327114543840. [PubMed: 25233898].
  • 6. Chen Y, Nie YC, Luo YL, Lin F, Zheng YF, Cheng GH, et al. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol. 2013;58:133-40. doi: 10.1016/j.fct.2013.04.024. [PubMed: 23603004].
  • 7. Argentieri M, Macchia F, Papadia P, Fanizzi FP, Avato P. Bioactive compounds from Capparis spinosa subsp. rupestris. Ind Crops Prod. 2012;36(1):65-9. doi: 10.1016/j.indcrop.2011.08.007.
  • 8. Ranjbar A. Evidence of oxidative damage in paraquat toxicity. Zahedan J Res Med Sci. 2014;16(121-8).
  • 9. Wang W, Pei X, Xu M, Sun S, Zhang C, Mu K, et al. The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury. Iran J Pharm Res. 2015;14(2):573-83. [PubMed: 25901166].
  • 10. Sun Y, Zhang J, Yan Y, Chi M, Chen W, Sun P, et al. The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats. Environ Toxicol Pharmacol. 2011;32(2):168-74. doi: 10.1016/j.etap.2011.04.008. [PubMed: 21843796].
  • 11. Malayeri AR, Hemmati AA, Arzi A, Rezaie A, Ghafurian-Boroojerdnia M, Khalili HR. A Comparison of the Effects of Quercetin Hydrate With Those of Vitamin E on the Levels of IL-13, PDGF, TNF-α, and INF-γ in Bleomycin-Induced Pulmonary Fibrosis in Rats. Jundishapur J Nat Pharm Prod. 2016;11(2). doi: 10.17795/jjnpp-27705.
  • 12. Kalantar M, Houshmand G, Kalantar H, Asadi M, Goudarzi M. Protective effect of hydroalcoholic extract of lavandula officinalis L. on gentamicin induced nephrotoxicity in rats. J Babol Univ Med Sci. 2016;18(7):62-7.
  • 13. Goudarzi M, Kalantar M, Kalantar H. The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats. Jundishapur J Nat Pharm Prod. 2017;12(4). e12345. doi: 10.5812/jjnpp.12345.
  • 14. Nabavi SF, Habtemariam S, Jafari M, Sureda A, Nabavi SM. Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bull Environ Contam Toxicol. 2012;89(1):73-7. doi: 10.1007/s00128-012-0645-4. [PubMed: 22531840].
  • 15. Nikbakht J, Hemmati AA, Arzi A, Mansouri MT, Rezaie A, Ghafourian M. Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats. Pharmacol Rep. 2015;67(6):1061-7. doi: 10.1016/j.pharep.2015.03.012. [PubMed: 26481523].
  • 16. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem. 1996;29(3):225-9. doi: 10.1016/0009-9120(96)00003-6. [PubMed: 8740508].
  • 17. Buege JA, Aust SD. [30] Microsomal lipid peroxidation. Methods in Enzymology. 1978;52:302-10. doi: 10.1016/s0076-6879(78)52032-6.
  • 18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54. doi: 10.1016/0003-2697(76)90527-3. [PubMed: 942051].
  • 19. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70-7. doi: 10.1016/0003-9861(59)90090-6. [PubMed: 13650640].
  • 20. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6. doi: 10.1016/S0076-6879(84)05016-3. [PubMed: 6727660].
  • 21. Martin JJ, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys. 1987;255(2):329-36. doi: 10.1016/0003-9861(87)90400-0. [PubMed: 3036004].
  • 22. Kalantar M, Shirali S, Hasanvand A, Valizadeh M, Tavakoli R, Asadi M. Ameliorative Effects of hydroalcoholic extract of lavandula officinalis L. on methotrexate-induced oxidative stress in rats: Effects of LOE on MTX-induced oxidative stress. Pharm Sci. 2017;23(1).
  • 23. Goudarzi M, Esmaeilizadeh M, Dolatshahi M, Kalantar H, Frouzandeh H, Kalantar M. Protective Effect of Elaeagnus angustifolia L. Fruit Hydroalcoholic Extract on Cyclophosphamide-Induced Nephrotoxicity in Mice. Shiraz E-Med J. 2018;19(1). e55075. doi: 10.5812/semj.55075.
  • 24. Ebrahimi Naghani E, Javadi I, Rashidi Nooshabadi M, Goudarzi M, Houshmand GR. Protective effects of hydroalcoholic extract of hypericum perforatum against bleomycin-induced pulmonary fibrosis in rats. J Babol Univ Med Sci. 2016;18(1):44-51.
  • 25. Hemmeti AA, Zerafatfard MR, Goudarzi M, Khodayar MJ, Rezaie A, Rashidi Nooshabadi MR, et al. Ameliorative effects of atorvastatin on bleomycin-induced pulmonary fibrosis in rats. Jundishapur J Nat Pharm Prod. 2016;11(4). doi: 10.17795/jjnpp-13370.
  • 26. Javadi I, Rashidi Nooshabadi MR, Goudarzi M, Roudbari R. Protective effects of celery (Apium graveloens) seed extract on bleomycin-induced pulmonary fibrosis in rats. J Babol Univ Med Sci. 2015;16(13):70-6.
  • 27. Dinis-Oliveira RJ, Duarte JA, Sanchez-Navarro A, Remiao F, Bastos ML, Carvalho F. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 2008;38(1):13-71. doi: 10.1080/10408440701669959. [PubMed: 18161502].
  • 28. Cheresh P, Kim SJ, Tulasiram S, Kamp DW. Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta. 2013;1832(7):1028-40. doi: 10.1016/j.bbadis.2012.11.021. [PubMed: 23219955].
  • 29. Amirshahrokhi K. Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice. Int Immunopharmacol. 2013;17(2):210-5. doi: 10.1016/j.intimp.2013.06.005. [PubMed: 23810410].
  • 30. Amirshahrokhi K, Bohlooli S. Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice. Inflammation. 2013;36(5):1111-21. doi: 10.1007/s10753-013-9645-8. [PubMed: 23595869].
  • 31. Nabavi SM, Habtemariam S, Nabavi SF, Sureda A, Daglia M, Moghaddam AH, et al. Protective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat's kidney. Mol Cell Biochem. 2013;372(1-2):233-9. doi: 10.1007/s11010-012-1464-y. [PubMed: 23014933].
  • 32. Vijaya Padma V, Sowmya P, Arun Felix T, Baskaran R, Poornima P. Protective effect of gallic acid against lindane induced toxicity in experimental rats. Food Chem Toxicol. 2011;49(4):991-8. doi: 10.1016/j.fct.2011.01.005. [PubMed: 21219962].
  • 33. You H, Wei L, Sun WL, Wang L, Yang ZL, Liu Y, et al. The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats. Int J Mol Med. 2014;34(1):92-102. doi: 10.3892/ijmm.2014.1745. [PubMed: 24736877].
  • 34. Rocco PR, Facchinetti LD, Ferreira HC, Negri EM, Capelozzi VL, Faffe DS, et al. Time course of respiratory mechanics and pulmonary structural remodelling in acute lung injury. Respir Physiol Neurobiol. 2004;143(1):49-61. doi: 10.1016/j.resp.2004.06.017. [PubMed: 15477172].
  • 35. Baowen Q, Yulin Z, Xin W, Wenjing X, Hao Z, Zhizhi C, et al. A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and inflammatory cytokines in pulmonary fibrosis. Eur J Pharmacol. 2010;642(1-3):134-9. doi: 10.1016/j.ejphar.2010.05.019. [PubMed: 20510684].
  • 36. Abidi A, Aissani N, Sebai H, Serairi R, Kourda N, Ben Khamsa S. Protective Effect of Pistacia lentiscus Oil Against Bleomycin-Induced Lung Fibrosis and Oxidative Stress in Rat. Nutr Cancer. 2017;69(3):490-7. doi: 10.1080/01635581.2017.1283423. [PubMed: 28287322].
  • 37. Huang M, Lou D, Li HH, Cai Q, Wang YP, Yang HF. Pyrrolidine dithiocarbamate attenuates paraquat-induced acute pulmonary poisoning in vivo via transforming growth factor beta1 and nuclear factor kappaB pathway interaction. Hum Exp Toxicol. 2016;35(12):1312-8. doi: 10.1177/0960327116630351. [PubMed: 26860689].
  • 38. Shen H, Wu N, Wang Y, Zhao H, Zhang L, Li T, et al. Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis. Int Immunopharmacol. 2017;46:16-22. doi: 10.1016/j.intimp.2017.02.020. [PubMed: 28249220].
  • 39. Zhi Q, Sun H, Qian X, Yang L. Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat? Int Immunopharmacol. 2011;11(1):96-102. doi: 10.1016/j.intimp.2010.10.012. [PubMed: 21040696].
  • 40. Chuang CY, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL. Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J Agric Food Chem. 2010;58(5):2943-51. doi: 10.1021/jf9043265. [PubMed: 20151649].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments