Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar
Uncorrected Proof scheduled for 14 (1)

Structural Characterization of the Recombinant Human Fibroblast Growth Factor Receptor 2b Kinase Domain Upon Interaction with Flavonoids

Hossein Piri 1 , Faezah Seyyed-Attaran 2 , Nematollah Gheibi 1 , Reza Najafipour 1 , Majid Sirati-Sabet 3 , Sajjad Asl-Fallah 4 and Dariush Ilghari 5 , *
Authors Information
1 Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
2 Islamic Azad University of Damghan, Damghan, Iran
3 Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Student Research Committee, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
5 College of Pharmacy, University of Texas, Austin, USA
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: In Press (In Press); e12499
  • Published Online: December 5, 2018
  • Article Type: Research Article
  • Received: May 3, 2017
  • Revised: December 5, 2017
  • Accepted: December 24, 2017
  • DOI: 10.5812/jjnpp.12499

To Cite: Piri H, Seyyed-Attaran F , Gheibi N, Najafipour R, Sirati-Sabet M, et al. Structural Characterization of the Recombinant Human Fibroblast Growth Factor Receptor 2b Kinase Domain Upon Interaction with Flavonoids, Jundishapur J Nat Pharm Prod. Online ahead of Print ; In Press(In Press):e12499. doi: 10.5812/jjnpp.12499.

Copyright © 2018, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Lee LT, Huang YT, Hwang JJ, Lee AY, Ke FC, Huang CJ, et al. Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: Effect on invasive potential of human carcinoma cells. Biochem Pharmacol. 2004;67(11):2103-14. doi: 10.1016/j.bcp.2004.02.023. [PubMed: 15135307].
  • 2. Chin YW, Kong JY, Han SY. Flavonoids as receptor tyrosine kinase FLT3 inhibitors. Bioorg Med Chem Lett. 2013;23(6):1768-70. doi: 10.1016/j.bmcl.2013.01.049. [PubMed: 23411073].
  • 3. Hou DX, Kumamoto T. Flavonoids as protein kinase inhibitors for cancer chemoprevention: Direct binding and molecular modeling. Antioxid Redox Signal. 2010;13(5):691-719. doi: 10.1089/ars.2009.2816. [PubMed: 20070239].
  • 4. Beenken A, Mohammadi M. The FGF family: Biology, pathophysiology and therapy. Nat Rev Drug Discov. 2009;8(3):235-53. doi: 10.1038/nrd2792. [PubMed: 19247306]. [PubMed Central: PMC3684054].
  • 5. Bode AM, Dong Z. Signal transduction and molecular targets of selected flavonoids. Antioxid Redox Signal. 2013;19(2):163-80. doi: 10.1089/ars.2013.5251. [PubMed: 23458437]. [PubMed Central: PMC3689254].
  • 6. Ahmad N, Gali H, Javed S, Agarwal R. Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. Biochem Biophys Res Commun. 1998;247(2):294-301. doi: 10.1006/bbrc.1998.8748. [PubMed: 9642119].
  • 7. Kim MH, Tsuhako AL, Co EW, Aftab DT, Bentzien F, Chen J, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012;22(15):4979-85. doi: 10.1016/j.bmcl.2012.06.029. [PubMed: 22765894].
  • 8. Wenzel U, Kuntz S, Daniel H. Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. J Pharmacol Exp Ther. 2001;299(1):351-7. [PubMed: 11561098].
  • 9. Song H, Chen C, Zhao S, Ge F, Liu D, Shi D, et al. Interaction of gallic acid with trypsin analyzed by spectroscopy. J Food Drug Anal. 2015;23(2):234-42. doi: 10.1016/j.jfda.2014.09.001. [PubMed: 28911378].
  • 10. Zuo Y, Chen H, Deng Y. Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta. 2002;57(2):307-16. [PubMed: 18968631].
  • 11. Do QD, Angkawijaya AE, Tran-Nguyen PL, Huynh LH, Soetaredjo FE, Ismadji S, et al. Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. J Food Drug Anal. 2014;22(3):296-302. doi: 10.1016/j.jfda.2013.11.001. [PubMed: 28911418].
  • 12. Lu Y, Jiang F, Jiang H, Wu K, Zheng X, Cai Y, et al. Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur J Pharmacol. 2010;641(2-3):102-7. doi: 10.1016/j.ejphar.2010.05.043. [PubMed: 20553913]. [PubMed Central: PMC3003697].
  • 13. Zhan M, Guo M, Jiang Y, Wang X. Characterization of the interaction between gallic acid and lysozyme by molecular dynamics simulation and optical spectroscopy. Int J Mol Sci. 2015;16(7):14786-807. doi: 10.3390/ijms160714786. [PubMed: 26140374]. [PubMed Central: PMC4519872].
  • 14. Mansouri MT, Naghizadeh B, Ghorbanzadeh B, Farbood Y, Sarkaki A, Bavarsad K. Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats. Pharmacol Biochem Behav. 2013;111:90-6. doi: 10.1016/j.pbb.2013.09.002. [PubMed: 24036471].
  • 15. Lu Z, Nie G, Belton PS, Tang H, Zhao B. Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives. Neurochem Int. 2006;48(4):263-74. doi: 10.1016/j.neuint.2005.10.010. [PubMed: 16343693].
  • 16. Locatelli C, Filippin-Monteiro FB, Creczynski-Pasa TB. Alkyl esters of gallic acid as anticancer agents: A review. Eur J Med Chem. 2013;60:233-9. doi: 10.1016/j.ejmech.2012.10.056. [PubMed: 23291333].
  • 17. Punithavathi VR, Prince PS, Kumar R, Selvakumari J. Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats. Eur J Pharmacol. 2011;650(1):465-71. doi: 10.1016/j.ejphar.2010.08.059. [PubMed: 20863784].
  • 18. Cushnie TP, Lamb AJ. Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents. 2011;38(2):99-107. doi: 10.1016/j.ijantimicag.2011.02.014. [PubMed: 21514796].
  • 19. Ramos-Escudero F, Morales MT, Asuero AG. Characterization of bioactive compounds from monovarietal virgin olive oils: Relationship between phenolic compounds-antioxidant capacities. Int J Food Properties. 2015;18(2):348-58. doi: 10.1080/10942912.2013.809542.
  • 20. Moghadasi M, Ilghari D, Sirati-Sabet M, Amini A, Asghari H, Gheibi N. Structural characterization of recombinant human fibroblast growth factor receptor 2b kinase domain upon interaction with omega fatty acids. Chem Phys Lipids. 2017;202:21-7. doi: 10.1016/j.chemphyslip.2016.11.005. [PubMed: 27871884].
  • 21. Gandia-Herrero F, Jimenez M, Cabanes J, Garcia-Carmona F, Escribano J. Tyrosinase inhibitory activity of cucumber compounds: Enzymes responsible for browning in cucumber. J Agric Food Chem. 2003;51(26):7764-9. doi: 10.1021/jf030131u. [PubMed: 14664542].
  • 22. Zankl A, Jaeger G, Bonafe L, Boltshauser E, Superti-Furga A. Novel mutation in the tyrosine kinase domain of FGFR2 in a patient with Pfeiffer syndrome. Am J Med Genet A. 2004;131(3):299-300. doi: 10.1002/ajmg.a.30366. [PubMed: 15523615].
  • 23. Zhang X, Li L, Xu Z, Liang Z, Su J, Huang J, et al. Investigation of the interaction of naringin palmitate with bovine serum albumin: Spectroscopic analysis and molecular docking. PLoS One. 2013;8(3). e59106. doi: 10.1371/journal.pone.0059106. [PubMed: 23527100]. [PubMed Central: PMC3604151].
  • 24. Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol. 1999;126(3):673-80. doi: 10.1038/sj.bjp.0702357. [PubMed: 10188978]. [PubMed Central: PMC1565862].
  • 25. Katoh M. Cancer genomics and genetics of FGFR2 (Review). Int J Oncol. 2008;33(2):233-7. [PubMed: 18636142].
  • 26. Ferguson PJ, Kurowska E, Freeman DJ, Chambers AF, Koropatnick DJ. A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines. J Nutr. 2004;134(6):1529-35. doi: 10.1093/jn/134.6.1529. [PubMed: 15173424].
  • 27. Roy AS, Tripathy DR, Chatterjee A, Dasgupta S. A spectroscopic study of the interaction of the antioxidant naringin with bovine serum albumin. J Biophysic Chem. 2010;1(3):141. doi: 10.4236/jbpc.2010.13017.
  • 28. Grose R, Fantl V, Werner S, Chioni AM, Jarosz M, Rudling R, et al. The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J. 2007;26(5):1268-78. doi: 10.1038/sj.emboj.7601583. [PubMed: 17304214]. [PubMed Central: PMC1817631].
  • 29. Haugsten EM, Wiedlocha A, Olsnes S, Wesche J. Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res. 2010;8(11):1439-52. doi: 10.1158/1541-7786.MCR-10-0168. [PubMed: 21047773].
  • 30. Seyyed-Attaran F, Ilghari D, Gheibi N, Sahmani M, Piri H. [Expression and purification of the recombinant kinase domain of FGFR2b and study of its structural changes due to the interaction with gallic acid]. J Isfahan Med School. 2016;33(362):2143-51. Persian.
  • 31. Pari L, Amudha K. Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. Eur J Pharmacol. 2011;650(1):364-70. doi: 10.1016/j.ejphar.2010.09.068. [PubMed: 20950607].
  • 32. Sengupta B, Sengupta PK. The interaction of quercetin with human serum albumin: A fluorescence spectroscopic study. Biochem Biophys Res Commun. 2002;299(3):400-3. [PubMed: 12445814].
  • 33. Atomssa T, Gholap AV. Characterization and determination of catechins in green tea leaves using UV-visible spectrometer. J Eng Technol Res. 2015;7(1):22-31. doi: 10.5897/JETR2014.0527.
  • 34. Robic S. Mathematics, thermodynamics, and modeling to address ten common misconceptions about protein structure, folding, and stability. CBE Life Sci Educ. 2010;9(3):189-95. doi: 10.1187/cbe.10-03-0018. [PubMed: 20810950]. [PubMed Central: PMC2931665].
  • 35. Kishore D, Kundu S, Kayastha AM. Thermal, chemical and pH induced denaturation of a multimeric beta-galactosidase reveals multiple unfolding pathways. PLoS One. 2012;7(11). e50380. doi: 10.1371/journal.pone.0050380. [PubMed: 23185611]. [PubMed Central: PMC3503960].
  • 36. Moghadasi M, Ilghari D, Gheibi N, Sirati-Sabet M, Khabbaz F, Piri H. [Expression, purification and evaluation of the recombinant human fibroblast growth factor receptor 2b kinase domain]. J Qazvin Univ Med Sci. 2014;18(2):4-11. Persian.
  • 37. Haddad AQ, Venkateswaran V, Viswanathan L, Teahan SJ, Fleshner NE, Klotz LH. Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines. Prostate Cancer Prostatic Dis. 2006;9(1):68-76. doi: 10.1038/sj.pcan.4500845. [PubMed: 16314891].
  • 38. Mahajan N, Mahmood A. Effect of gallic acid on alkaline phosphatase and peptidase activities in rat intestine. Indian J Biochem Biophys. 2009;46(5):378-82. [PubMed: 20027867].
  • 39. Guimaraes R, Calhelha RC, Froufe HJ, Abreu RM, Carvalho AM, Queiroz MJ, et al. Wild Roman chamomile extracts and phenolic compounds: Enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. Food Funct. 2016;7(1):79-83. doi: 10.1039/c5fo00586h. [PubMed: 26446815].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments