Jundishapur Journal of Natural Pharmaceutical Products

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Gastroprotective Effects of Pistacia atlantica Extract on Ethanol-Induced Gastric Ulcers in Rats

Neda Sistani Karampour 1 , Ardeshir Arzi 1 , * , Annahita Rezaie 2 , Fatemeh Ghasemi 3 and Marzieh Pashmforosh 1
Authors Information
1 Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 28, 2019, 14 (1); e13635
  • Published Online: January 12, 2019
  • Article Type: Research Article
  • Received: March 3, 2017
  • Revised: May 24, 2017
  • Accepted: June 25, 2017
  • DOI: 10.5812/jjnpp.13635

To Cite: Sistani Karampour N, Arzi A, Rezaie A, Ghasemi F, Pashmforosh M. Gastroprotective Effects of Pistacia atlantica Extract on Ethanol-Induced Gastric Ulcers in Rats, Jundishapur J Nat Pharm Prod. 2019 ; 14(1):e13635. doi: 10.5812/jjnpp.13635.

Copyright © 2019, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Mota KS, Dias GE, Pinto ME, Luiz-Ferreira A, Souza-Brito AR, Hiruma-Lima CA, et al. Flavonoids with gastroprotective activity. Molecules. 2009;14(3):979-1012. doi: 10.3390/molecules14030979. [PubMed: 19305355]. [PubMed Central: PMC6253827].
  • 2. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol. 2002;53(1):39-50. [PubMed: 11939718].
  • 3. Manjari V, Das UN. Oxidant stress, anti-oxidants, nitric oxide and essential fatty acids in peptic ulcer disease. Prostaglandins Leukot Essent Fatty Acids. 1998;59(6):401-6. [PubMed: 10102386].
  • 4. Rao Ch V, Ojha SK, Radhakrishnan K, Govindarajan R, Rastogi S, Mehrotra S, et al. Antiulcer activity of Utleria salicifolia rhizome extract. J Ethnopharmacol. 2004;91(2-3):243-9. doi: 10.1016/j.jep.2003.12.020. [PubMed: 15120446].
  • 5. Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Involvement of reactive oxygen species in gastric ulceration: Protection by melatonin. Indian J Exp Biol. 2002;40(6):693-705. [PubMed: 12587717].
  • 6. Lehne RA, Rosenthal L. Pharmacology for nursing care. Elsevier Health Sciences; 2014.
  • 7. Nwidu LL, Nwafor PA. Gastroprotective effects of leaf extracts of Carpolobia lutea (polygalaceae) G. Don. in rats. Afr J Biotechnol. 2009;8(1).
  • 8. Jainu M, Vijai Mohan K, Shyamala Devi CS. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res. 2006;123(6):799-806. [PubMed: 16885602].
  • 9. Ghalem BR, Mohamed B. Essential oil from gum of Pistacia atlantica Desf.: Screening of antimicrobial activity. Afr J Pharm Pharmaco. 2009;3(3):87-91.
  • 10. Ahmad NS, Waheed A, Farman M, Qayyum A. Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice. J Ethnopharmacol. 2010;129(2):250-3. doi: 10.1016/j.jep.2010.03.017. [PubMed: 20359528].
  • 11. Rhouma A, Ben Daoud H, Ghanmi S, Ben Salah H, Romdhane M, Demak M. Antimicrobial activities of leaf extracts of Pistacia and Schinus species against some plant pathogenic fungi and bacteria. J Plant Pathol. 2009:339-45.
  • 12. Farhoosh R, Tavassoli-Kafrani MH, Sharif A. Antioxidant activity of the fractions separated from the unsaponifiable matter of bene hull oil. Food Chem. 2011;126(2):583-9. doi: 10.1016/j.foodchem.2010.11.047.
  • 13. Delazar A, Reid RG, Sarker SD. GC-MS analysis of the essential oil from the oleoresin of Pistacia atlantica var. mutica. Chem Nat Compd. 2004;40(1):24-7. doi: 10.1023/B:CONC.0000025459.72590.9e.
  • 14. Gourine N, Yousfi M, Bombarda I, Nadjemi B, Stocker P, Gaydou EM. Antioxidant activities and chemical composition of essential oil of Pistacia atlantica from Algeria. Ind Crop Prod. 2010;31(2):203-8. doi: 10.1016/j.indcrop.2009.10.003.
  • 15. Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol. 2009;123(3):464-9. doi: 10.1016/j.jep.2009.03.024. [PubMed: 19501279].
  • 16. Sanchez-Mendoza ME, Reyes-Trejo B, Sanchez-Gomez P, Rodriguez-Silverio J, Castillo-Henkel C, Cervantes-Cuevas H, et al. Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: role of nitric oxide, prostaglandins and sulfydryls. Fitoterapia. 2010;81(1):66-71. doi: 10.1016/j.fitote.2009.07.009. [PubMed: 19651191].
  • 17. Morsy MA, Heeba GH, Abdelwahab SA, Rofaeil RR. Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: role of NO, HO-1, and COX-1,2. Nitric Oxide. 2012;27(2):117-22. doi: 10.1016/j.niox.2012.06.001. [PubMed: 22687651].
  • 18. Morsy MA, Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res. 2008;22(10):1361-6. doi: 10.1002/ptr.2502. [PubMed: 18543354].
  • 19. Antonisamy P, Duraipandiyan V, Aravinthan A, Al-Dhabi NA, Ignacimuthu S, Choi KC, et al. Protective effects of friedelin isolated from Azima tetracantha Lam. against ethanol-induced gastric ulcer in rats and possible underlying mechanisms. Eur J Pharmacol. 2015;750:167-75. doi: 10.1016/j.ejphar.2015.01.015. [PubMed: 25617794].
  • 20. Arawwawala LD, Thabrew MI, Arambewela LS. Gastroprotective activity of Trichosanthes cucumerina in rats. J Ethnopharmacol. 2010;127(3):750-4. doi: 10.1016/j.jep.2009.11.026. [PubMed: 19963056].
  • 21. Bafna PA, Balaraman R. Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation. J Ethnopharmacol. 2004;90(1):123-7. [PubMed: 14698519].
  • 22. Santos Cerqueira G, dos Santos e Silva G, Rios Vasconcelos E, Fragoso de Freitas AP, Arcanjo Moura B, Silveira Macedo D, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012;683(1-3):260-9. doi: 10.1016/j.ejphar.2012.02.043. [PubMed: 22426163].
  • 23. Kath RK, Gupta RK. Antioxidant activity of hydroalcoholic leaf extract of ocimum sanctum in animal models of peptic ulcer. Indian J Physiol Pharmacol. 2006;50(4):391-6. [PubMed: 17402269].
  • 24. Rodriguez JA, Theoduloz C, Yanez T, Becerra J, Schmeda-Hirschmann G. Gastroprotective and ulcer healing effect of ferruginol in mice and rats: Assessment of its mechanism of action using in vitro models. Life Sci. 2006;78(21):2503-9. doi: 10.1016/j.lfs.2005.10.018. [PubMed: 16309708].
  • 25. Benhammou N, Bekkara FA, Panovska TK. Antiradical capacity of the phenolic compounds oF Pistacia lentiscus L. AND Pistacia atlantica desf. Adv Food Sci. 2007;29(3):155-61.
  • 26. Peksel A, Arisan‐Atac IN, Yanardag R. Evaluation of antioxidant and antiacetylcholinesterase activities of the extracts of Pistacia atlantica Desf. Leaves. J Food Biochem. 2010;34(3):451-76. doi: 10.1111/j.1745-4514.2009.00290.x.
  • 27. Sharifi MS, Hazell SL. GC-MS analysis and antimicrobial activity of the essential oil of the trunk exudates from Pistacia atlantica kurdica. J Pharm Sci Res. 2011;3(8):1364.
  • 28. Sharifi MS, Hazell SL. Isolation, analysis and antimicrobial activity of the acidic fractions of Mastic, Kurdica, Mutica and Cabolica gums from genus Pistacia. Glob J Health Sci. 2011;4(1):217-28. doi: 10.5539/gjhs.v4n1p217. [PubMed: 22980113]. [PubMed Central: PMC4777032].
  • 29. Tanideh N, Masoumi S, Hosseinzadeh M, Safarpour AR, Erjaee H, Koohi-Hosseinabadi O, et al. Healing effect of pistacia atlantica fruit oil extract in acetic Acid-induced colitis in rats. Iran J Med Sci. 2014;39(6):522-8. [PubMed: 25429174]. [PubMed Central: PMC4242986].
  • 30. Minaiyan M, Karimi F, Ghannadi A. Anti-inflammatory effect of Pistacia atlantica subsp. kurdica volatile oil and gum on acetic acid-induced acute colitis in rat. Res J Pharmacog. 2015;2(2):1-12.
  • 31. Ghaedi T, Mirzaei A, Laameerad B. Protective effect of Pistacia khinjuk on gentamicin-induced nephrotoxicity in rats. World J Pharm Pharm Sci. 2014;3:919-26.

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