Jundishapur Journal of Natural Pharmaceutical Products

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Formulation and Characterization of Oral Mucoadhesive Chlorhexidine Tablets Using Cordia myxa Mucilage

Eskandar Moghimipour 1 , 2 , * , Nasrin Aghel 1 and Akram Adelpour 1
Authors Information
1 Medicinal Plant Research Center, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: October 7, 2012, 7 (4); 129-133
  • Published Online: October 7, 2012
  • Article Type: Research Article
  • Received: November 8, 2011
  • Revised: July 18, 2012
  • Accepted: July 25, 2012
  • DOI: 10.17795/jjnpp-3388

To Cite: Moghimipour E, Aghel N, Adelpour A. Formulation and Characterization of Oral Mucoadhesive Chlorhexidine Tablets Using Cordia myxa Mucilage, Jundishapur J Nat Pharm Prod. 2012 ; 7(4):129-133. doi: 10.17795/jjnpp-3388.

Abstract
Copyright © 2012, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Rathbone MJ, Drummond BK, Tucker IG. The oral cavity as a site for systemic drug delivery. Advanced drug delivery reviews. 1994; 13(1): 1-22[DOI]
  • 2. Ameye D, Mus D, Foreman P, Remon JP. Spray-dried Amioca starch/Carbopol 974 mixtures as buccal bioadhesive carriers. Int J Pharm. 2005; 301: 170-80[DOI][PubMed]
  • 3. Varshosaz J, Dehghan Z. Development and characterization of buccoadhesive nifedipine tablets. Eur J Pharm Biopharm. 2002; 54(2): 135-41[DOI]
  • 4. Senel S, Ikinci G, Kas S, Yousefi-Rad A, Sargon MF, Hincal AA. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm. 2000; 193(2): 197-203[DOI]
  • 5. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 2008; 66(3): 441-5[DOI][PubMed]
  • 6. Marriott C, Gregory NP. Bioadhesive Drug Delivery Systems. 1990; : 1-24[PubMed]
  • 7. Allen A, Cunliffe WJ, Pearson JP, Venables CW. The adherent gastric mucus gel barrier in man and changes in peptic ulceration. J Intern Med Suppl. 1990; 732: 83-90[PubMed]
  • 8. Kerss S, Allen A, Garner A. A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, prostaglandin, N-acetylcysteine and other agents. Clin Sci (Lond). 1982; 63(2): 187-95
  • 9. Sonju T, Christensen TB, Kornstad L, Rolla G. Electron microscopy, carbohydrate analyses and biological activities of the proteins adsorbed in two hours to tooth surfaces in vivo. Caries Res. 1974; 8(2): 113-22[DOI][PubMed]
  • 10. Al-Awadi FM, Srikumar TS, Anim JT, Khan I. Antiinflammatory effects of Cordia myxa fruit on experimentally induced colitis in rats. Nutrition. 2001; 17(5): 391-6[DOI]
  • 11. Chanda R, Nath LK, Mahapatra S. Formulation development of oral mucoadhesive coated Terbutaline sulphate tablets using some natural materials extracted from edible fruits available in India. Iran J Pharm Sci. 2009; 5(1): 3-12
  • 12. Carlo Ceschel G, Bergamante V, Calabrese V, Biserni S, Ronchi C, Fini A. Design and evaluation in vitro of controlled release mucoadhesive tablets containing chlorhexidine. Drug Dev Ind Pharm. 2006; 32(1): 53-61[DOI][PubMed]
  • 13. Patil BS, Tate SS, Kulkarni U, RC H, Wadageri GV. Development and In-Vitro Evaluation of Mucoadhesive Buccal Tablets of Tizanidine Hydrochloride Using Natural Polymer Xanthan Gum. Int J Pharm Sci. 2011; 8(2): 140-6
  • 14. Arora G, Malik K, Singh I, Arora S. Formulation and Evaluation of Controlled Release Mucoadhesive Matrix Tablets: Assessment of Myrrh Oleo Gum Resin as a Natural Pharmaceutical Excipient. Int J Pharm Sci Drug Res. 2011; 3(2): 84-8
  • 15. Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs. J Control Release. 2006; 114(1): 15-40[DOI][PubMed]
  • 16. Miyazaki S, Kawasaki N, Nakamura T, Iwatsu M, Hou WM, Attwood D. Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation. Int J Pharm. 2000; 204(1-2): 127-32[DOI]
  • 17. Ikinci G, Senel S, Wilson CG, Sumnu M. Development of a buccal bioadhesive nicotine tablet formulation for smoking cessation. Int J Pharm. 2004; 277(1-2): 173-8[DOI][PubMed]
  • 18. Vazquez M, Perez-Marcos B, Gomez-Amoza J, -Pacheco RA, Souto C, Concheiro A. Influence of technological variables on release of drugs from hydrophilic matrices. Drug Dev Indus Pharm. 1992; 18(11-12): 1355-75[DOI]
  • 19. Velasco MV, Ford JL, Rowe P, Rajabi-Siahboomi AR. Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J Control Release. 1999; 57(1): 75-85[DOI]
  • 20. Owens TS, Dansereau RJ, Sakr A. Development and evaluation of extended release bioadhesive sodium fluoride tablets. Int J Pharm. 2005; 288(1): 109-22[DOI][PubMed]
  • 21. Thirawong N, Nunthanid J, Puttipipatkhachorn S, Sriamornsak P. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur J Pharm Biopharm. 2007; 67(1): 132-40[DOI][PubMed]
  • 22. Leung SHS, Robinson JR. Polymer structure features contributing to mucoadhesion. II. J Control Release. 1990; 12(3): 187-94[DOI]
  • 23. Wong CF, Yuen KH, Peh KK. An in-vitro method for buccal adhesion studies: importance of instrument variables. Int J Pharm. 1999; 180(1): 47-57[DOI]
  • 24. Tsutsumi K, Obata Y, Nagai T, Loftsson T, Takayama K. Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs. Int J Pharm. 2002; 238(1-2): 161-70[DOI]
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