Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Comparing the effect of Glucosamine and Glucosamine With Alendronate in Symptomatic Relieve of Degenerative Knee Joint Disease: A Double- blind Randomized Clinical Trial Study

Hamid Reza Arti 1 , * and Mohammad Ebrahim Azemi 2 , 3
Authors Information
1 Department of Orthopedic Surgery School of Medicine Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Department of Pharmacognosy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Medical Herbs and Natural Products Research Center, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 25, 2012, 7 (3); 87-92
  • Published Online: August 25, 2012
  • Article Type: Research Article
  • Received: November 3, 2011
  • Revised: March 3, 2012
  • Accepted: April 30, 2012
  • DOI: 10.17795/jjnpp-3405

To Cite: Arti H R, Azemi M E. Comparing the effect of Glucosamine and Glucosamine With Alendronate in Symptomatic Relieve of Degenerative Knee Joint Disease: A Double- blind Randomized Clinical Trial Study, Jundishapur J Nat Pharm Prod. 2012 ; 7(3):87-92. doi: 10.17795/jjnpp-3405.

Abstract
Copyright © 2012, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Mankin HJ, Brandt KD. Osteoarthritis, diagnosis and management. 2007; : 109-19
  • 2. Haq SA, Davatchi F. Osteoarthritis of the knees in the COPCORD world. Int J Rheum Dis. 2011; 14(2): 122-9[DOI][PubMed]
  • 3. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol. 1999; 26(11): 2423-30[PubMed]
  • 4. Luke R, Bucci F. Nature and treatment optiom of osteoarthritis. ACA J Chirop. 2003; 162: 251-6
  • 5. McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med. 2004; 117(9): 643-9[DOI][PubMed]
  • 6. Cibere J, Kopec JA, Thorne A, Singer J, Canvin J, Robinson DB, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum. 2004; 51(5): 738-45[DOI]
  • 7. Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006; 354(8): 795-808[DOI][PubMed]
  • 8. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998; 48(5): 469-74[PubMed]
  • 9. Carbone LD, Nevitt MC, Wildy K, Barrow KD, Harris F, Felson D, et al. The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis. Arthritis Rheum. 2004; 50(11): 3516-25[DOI]
  • 10. Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004; 50(4): 1193-206[DOI]
  • 11. Arti HR, Mehdinasab SA. The comparison effects of intra-articular injection of different opioids on postoperative pain relieve after arthroscopic anterior cruciate ligament reconstruction: A randomized clinical trial study. J Res Med Sci. 2011; 16(9): 1176-1182
  • 12. Heisel J, Forster KK. [Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy]. Arzneimittelforschung. 2007; 57(4): 203-17[PubMed]
  • 13. Chu SC, Yang SF, Lue KH, Hsieh YS, Lee CY, Chou MC, et al. Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clin Chim Acta. 2006; 372(1-2): 167-72[DOI][PubMed]
  • 14. Distler J, Anguelouch A. Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis. J Am Acad Nurse Pract. 2006; 18(10): 487-93[DOI][PubMed]
  • 15. Moroni A, Faldini C, Hoang-Kim A, Pegreffi F, Giannini S. Alendronate improves screw fixation in osteoporotic bone. J Bone Joint Surg Am. 2007; 89(1): 96-101[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments