Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Saffron Reduced Toxic Effects of its Constituent, Safranal, in Acute and Subacute Toxicities in Rats

Toktam Ziaee 1 , Bibi Marjan Razavi 2 and Hossein Hosseinzadeh 3 , *
Authors Information
1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 20, 2013, 9 (1); 3-8
  • Published Online: February 20, 2013
  • Article Type: Research Article
  • Received: June 26, 2013
  • Revised: July 15, 2013
  • Accepted: July 22, 2013
  • DOI: 10.17795/jjnpp-13168

To Cite: Ziaee T, Razavi B M, Hosseinzadeh H. Saffron Reduced Toxic Effects of its Constituent, Safranal, in Acute and Subacute Toxicities in Rats, Jundishapur J Nat Pharm Prod. 2013 ; 9(1):3-8. doi: 10.17795/jjnpp-13168.

Abstract
Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Talha J, Priyanka M, Akanksha A. Hypertension and herbal plants. Int Res J Pharm. 2011; 2: 26-30
  • 2. Hosseinzadeh H, Nassiri-Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res. 2013; 27(4): 475-83[DOI][PubMed]
  • 3. Hosseinzadeh H, Khosravan V. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arc Iran Med. 2002; 5(1): 44
  • 4. Hosseinzadeh H, Karimi G, Niapoor M. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice I International Symposium on Saffron Biology and Biotechnology 650 : 435-45
  • 5. Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002; 2: 7[PubMed]
  • 6. Hosseinzadeh H, Shamsaie F, Mehri S. Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents, crocin and safranal. Pharmacogn Mag. 2009; 5(20): 419
  • 7. Hosseinzadeh H, Ghenaati J. Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Fitoterapia. 2006; 77(6): 446-8[DOI][PubMed]
  • 8. Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res. 2012; 26(3): 381-6[DOI][PubMed]
  • 9. Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 2010; 24(7): 990-4[DOI][PubMed]
  • 10. Moallem SA, Hariri AT, Mahmoudi M, Hosseinzadeh H. Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. Toxicol Ind Health. 2012; [DOI][PubMed]
  • 11. Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. Food Chem Toxicol. 2010; 48(10): 2803-8[DOI][PubMed]
  • 12. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013; 16(1): 64-72[PubMed]
  • 13. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012; 32(2): 227-35[DOI][PubMed]
  • 14. Posadzki P, Watson LK, Ernst E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med. 2013; 13(1): 7-12[PubMed]
  • 15. Karimi G, Tabibi N, Hosseinzadeh H, Shirzad F. Sub-acute toxicity of saffron (Crocus sativus L.) stigma and petal in rats. J Med Plants. 2004; 12: 32-9
  • 16. Rezaee R, Hosseinzadeh H. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci. 2013; 16(1): 12-26[PubMed]
  • 17. Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res. 2009; 23(6): 768-74[DOI][PubMed]
  • 18. Hosseinzadeh H, Talebzadeh F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia. 2005; 76(7-8): 722-4[DOI][PubMed]
  • 19. Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 2012; 83(5): 888-95[DOI][PubMed]
  • 20. Hosseinzadeh H, Sadeghi Shakib S, Khadem Sameni A, Taghiabadi E. Acute and Subacute Toxicity of Safranal, a Constituent of Saffron, in Mice and Rats. Iran J Pharm Res. 2013; 12(1): 93-9
  • 21. Kamboj VP. Herbal medicine. Cur Sci. 2000; 78(1): 35-8
  • 22. Mirheydar H. Herbal information: Application of Herbs in Prevention and Treatment of Deseases. 2001;
  • 23. Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med. 2008; 23(6): 854-9[DOI][PubMed]
  • 24. Hosseinzadeh H, Shariaty MV, Khadem Sameni A, Vahabzadeh M, Ríos JL, Recio MC, et al. Acute and sub-acute toxicity of crocin, a constituent of Crocus sativus L.(saffron), in mice and rats. Pharmacol online. 2010; 2: 943-51
  • 25. Mohamadpour AH, Ayati Z, Parizadeh MR, Rajbai O, Hosseinzadeh H. Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers. Iran J Basic Med Sci. 2013; 16(1): 39-46[PubMed]
  • 26. Whole-Herb Healing Or Standardized Plant Constituents? 2013;
  • 27. Bathaie SZ, Mousavi SZ. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr. 2010; 50(8): 761-86[DOI][PubMed]
  • 28. Kianbakht S, Hajiaghaee R. Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. J Med Plants. 2011; 10(39): 82-9
  • 29. Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health. 2013; [DOI][PubMed]
  • 30. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci. 2005; 8(3): 387-93[PubMed]
  • 31. Ajami M, Eghtesadi S, Pazoki-Toroudi H, Habibey R, Ebrahimi SA. Effect of crocus sativus on gentamicin induced nephrotoxicity. Biol Res. 2010; 43(1): 83-90[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments