Jundishapur Journal of Natural Pharmaceutical Products

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Formulation and Evaluation of Liposomes for Transdermal Delivery of Celecoxib

Eskandar Moghimipour 1 , 2 , Anayatollah Salami 1 , 2 , * and Mahsa Monjezi 2
Authors Information
1 Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 01, 2015, 10 (1); e17653
  • Published Online: February 20, 2015
  • Article Type: Research Article
  • Received: January 17, 2014
  • Revised: March 3, 2014
  • Accepted: August 17, 2014
  • DOI: 10.17795/jjnpp-17653

To Cite: Moghimipour E, Salami A, Monjezi M. Formulation and Evaluation of Liposomes for Transdermal Delivery of Celecoxib, Jundishapur J Nat Pharm Prod. 2015 ; 10(1):e17653. doi: 10.17795/jjnpp-17653.

Copyright © 2015, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Hadgraft J, Lane ME. Skin permeation: the years of enlightenment. Int J Pharm. 2005; 305(1-2): 2-12[DOI][PubMed]
  • 2. Rao P, Knaus EE. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci. 2008; 11(2): 81s-110s[PubMed]
  • 3. Seedher N, Bhatia S. Solubility enhancement of Cox-2 inhibitors using various solvent systems. AAPS PharmSciTech. 2003; 4(3)[DOI][PubMed]
  • 4. Schoen RT, Vender RJ. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Am J Med. 1989; 86(4): 449-58[PubMed]
  • 5. Schafer AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol. 1995; 35(3): 209-19[PubMed]
  • 6. Simon LS, Lanza FL, Lipsky PE, Hubbard RC, Talwalker S, Schwartz BD, et al. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum. 1998; 41(9): 1591-602[DOI][PubMed]
  • 7. Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S. Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm. 2007; 57(3): 315-32[DOI][PubMed]
  • 8. Ventura CA, Giannone I, Paolino D, Pistara V, Corsaro A, Puglisi G. Preparation of celecoxib-dimethyl-beta-cyclodextrin inclusion complex: characterization and in vitro permeation study. Eur J Med Chem. 2005; 40(7): 624-31[DOI][PubMed]
  • 9. Paulson SK, Vaughn MB, Jessen SM, Lawal Y, Gresk CJ, Yan B, et al. Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. J Pharmacol Exp Ther. 2001; 297(2): 638-45[PubMed]
  • 10. Paradkar AR, Chauhan B, Yamamura S, Pawar AP. Preparation and characterization of glassy celecoxib. Drug Dev Ind Pharm. 2003; 29(7): 739-44[DOI][PubMed]
  • 11. Clemett D, Goa KL. Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain. Drugs. 2000; 59(4): 957-80[PubMed]
  • 12. Davies NM, McLachlan AJ, Day RO, Williams KM. Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2000; 38(3): 225-42[DOI][PubMed]
  • 13. Walter MF, Jacob RF, Day CA, Dahlborg R, Weng Y, Mason RP. Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs. Atherosclerosis. 2004; 177(2): 235-43[DOI][PubMed]
  • 14. Paulson SK, Kaprak TA, Gresk CJ, Fast DM, Baratta MT, Burton EG, et al. Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human. Biopharm Drug Dispos. 1999; 20(6): 293-9[PubMed]
  • 15. Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 2005; 352(11): 1071-80[DOI][PubMed]
  • 16. Pai RS, Devi KV. Lamivudine liposomes for Transdermal Delivery-Formulation, characterization, Stability, and In-vitro Evaluation. Int J Pharm Sci Nanotechnol. 2009; 1: 317-26
  • 17. Moghimipour E, Salimi A, Sharifmakhmalzadeh B. Effect of the Various Solvents on the In Vitro Permeability of Vitamin B 12 through Excised Rat Skin. Trop J Pharm Res. 2013; 12(5): 671-7
  • 18. Moghimipour E, Handali S. Utilization of thin film method for preparation of celecoxib loaded liposomes. Adv Pharm Bull. 2012; 2(1): 93-8[DOI][PubMed]
  • 19. Chetanachan P, Akarachalanon P, Worawirunwong D, Dararutana P, Bangtrakulnonth A, Bunjop M, et al. Ultrastructural Characterization of Liposomes Using Transmission Electron Microscope. Adv Mat Res. 2008; 55: 709-11[DOI]
  • 20. Mohammadi-Samani S, Montaseri H, Jamshidnejad M. Preparation and evaluation of cyproterone acetate liposome for topical drug delivery. Iran J Pharm Sci. 2009; 5(4): 199-204
  • 21. Padamwar MN, Pokharkar VB. Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm. 2006; 320(1-2): 37-44[DOI][PubMed]
  • 22. Moghimipour E, Salimi A, Eftekhari S. Design and characterization of microemulsion systems for naproxen. Adv Pharm Bull. 2013; 3(1): 63-71[DOI][PubMed]
  • 23. Roberts MS, Cross SE. Percutaneous absorption of topically applied NSAIDS and other compounds: role of solute properties, skin physiology and delivery systems. Inflammopharmacology. 1999; 7(4): 339-50[DOI][PubMed]
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