Cite Score:
1.07
ELSEVIER SCOPUS

Soybean: a Potential Antipsoriasis Agent

AUTHORS

Nader Pazyar 1 , * , Reza Yaghoobi 1

AUTHORS INFORMATION

1 Department of Dermatology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 10 (1); e20924
Published Online: February 20, 2015
Article Type: Editorial
Received: June 7, 2014
Accepted: December 14, 2014
Crossmark

Crossmark

CHEKING

READ FULL TEXT

Keywords

Genistein Psoriasis Soybeans

Copyright © 2015, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Psoriasis is a chronic hyperproliferative skin disease, which affects approximately 2% to 4% of the general population. This immune-mediated disorder is characterized by erythematous scaling plaques ranging extensively in size on the scalp, elbows, knee, and other surfaces of the skin (1). Importantly, genetic, immunohistochemical, and pharmacologic investigations support a prominent role for nuclear factor kappa B (NFκB) pathway in pathophysiology of psoriasis (2). Numerous dermatological evidences indicate that tumor necrosis factor (TNF)-α is the pivotal immune mediator involved in psoriasis pathogenesis. This inflammatory cytokine induces antiapoptotic proteins in psoriatic skin (3, 4). Interleukin (IL)-1β and IL-6 are unanimously believed to be important in psoriasis disease. Of note, genetic polymorphisms related to IL-6 genes have a relationship with psoriasis that could have a potential effect on disorder counseling and management (5). IL-8 is a chemotactic pro-inflammatory cytokine for all types of migratory immune cells. Recently, Qazi et al. demonstrated the elevated production of IL-8 and/or its receptors in patients with psoriasis (6). Some scientific documents suggest that tissue angiotensin converting enzyme (ACE) activity in involved skin is significantly increased in patients with psoriasis. Additionally, assessment of therapeutic efficacy in psoriasis is attributed to determination of tissue ACE activity as a good nonspecific parameter (7).

Soybean (Glycine max) has been known as a golden bean (8). It has been established that isoflavones are the most abundant phytoestrogens in soybean and structurally similar to 17 beta-estradiol (9). Genistein is considered as the main isoflavone in soybean and exerts potent anti-inflammatory (10) and anti-oxidant properties (11). Soybean and genistein substantially have been safely used at high levels in several Asian populations in many centuries and play a brilliant role in health promotion (12). Notably, it has been clarified that genistein exerts antiproliferative activity by inhibiting NFκB signaling (13). There is a great deal of immunological evidence that genistein modulates inflammatory responses by reducing production and expression of pro-inflammatory biomarkers such as TNF-α, IL-1β, IL-6 and IL-8 (14-16). Xu et al. investigated (in vivo and in vitro) the association between genistein and changes of ACE in the rat model. They reported down-regulation of ACE with a consequent change in circulating levels of angiotensin II (Ang II) (17). Human neutrophil elastase is a serine protease, which is present in its active form in inflamed tissue as well as psoriatic lesions. It has been identified that genistein could inhibit neutrophil elastase release (18). To conclude, given several lines of documents indicating that genistein suppresses pro-inflammatory cytokines such as NF-κB, TNF-α, IL-1β, IL-6, IL-8 as well as ACE, also its inhibitory effect on elastase release, it could be proposed that topical application of genistein might be a potential therapeutic strategy for psoriasis therapy.

Because of the safety of genistein (12), its topical use might be recommended as adjuvant together with corticosteroids in psoriasis management, especially while treating patients resistant to the treatment. Ito et al. (19) investigated topical application of Glyteer (GL) (soybean) on a psoriatic model in mice; they observed that GL inhibits epidermal weight and its protein amount on the hyperplastic response in mice. In addition, GL inhibited edema in mice and inhibitory action of GL on edema had the same potency as those of betamethasone 17-valerate, indomethacin and cyclosporine. According to these results, researchers suggested that soybean might have a potent therapeutic effect on psoriasis disease. This study supported our commentary on potential administration of soybean as a potential armamentarium against psoriasis.

Finally, topical genistein found to decrease psoralen-ultraviolet A (PUVA)-induced skin thickening and greatly reduce cutaneous erythema and ulceration dose-dependently (20). Accordingly, in patients with psoriasis combining genistein with PUVA therapy might potentiate the therapeutic response of latter and protect against its complications. This paper should serve to encourage researchers to conduct clinical trials on this subject.

References
1 Pazyar N, Yaghoobi R. Tea tree oil as a novel antipsoriasis weapon. Skin Pharmacol Physiol. 2012; 25(3): 162-3[DOI][ PubMed ]
2 Derakhshan N. NFkappaB inhibitors as a potential novel hypothesized treatment for psoriasis. Sao Paulo Med J. 2011; 129(6): 433-4[ PubMed ]
3 Balato A, Lembo S, Cirillo T, Megna M, Raimondo A, Di Costanzo L. Anti-Tumor Necrosis Factor-alpha Therapy in the Management of Psoriasis and B-Chronic Lymphocytic Leukemia. Case Rep Dermatol. 2011; 3(1): 60-3[DOI][ PubMed ]
4 Avramidis G, Kruger-Krasagakis S, Krasagakis K, Fragiadaki I, Kokolakis G, Tosca A. The role of endothelial cell apoptosis in the effect of etanercept in psoriasis. Br J Dermatol. 2010; 163(5): 928-34[ PubMed ]
5 Pazyar N, Jamshydian N. Cepharanthine: a therapeutic potential candidate for psoriasis. J Altern Complement Med. 2012; 18(7): 639-40[DOI][ PubMed ]
6 Qazi BS, Tang K, Qazi A. Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis. Int J Inflam. 2011; 2011: 908468[DOI][ PubMed ]
7 Huskic J, Alendar F. Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis. Bosn J Basic Med Sci. 2007; 7(2): 103-6[ PubMed ]
8 Bansal N, Parle M. Effect of soybean supplementation on the memory of alprazolam-induced amnesic mice. J Pharm Bioallied Sci. 2010; 2(2): 144-7[DOI][ PubMed ]
9 Bu L, Lephart ED. AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones. BMC Neurosci. 2007; 8: 13[DOI][ PubMed ]
10 Kim JM, Uehara Y, Choi YJ, Ha YM, Ye BH, Yu BP, et al. Mechanism of attenuation of pro-inflammatory Ang II-induced NF-kappaB activation by genistein in the kidneys of male rats during aging. Biogerontology. 2011; 12(6): 537-50[DOI][ PubMed ]
11 Wei H, Saladi R, Lu Y, Wang Y, Palep SR, Moore J, et al. Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr. 2003; 133(11 Suppl 1): 3811S-9S[ PubMed ]
12 McClain RM, Wolz E, Davidovich A, Edwards J, Bausch J. Reproductive safety studies with genistein in rats. Food Chem Toxicol. 2007; 45(8): 1319-32[DOI][ PubMed ]
13 Seo HS, Choi HS, Choi HS, Choi YK, Um JY, Choi I, et al. Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells. Anticancer Res. 2011; 31(10): 3301-13[ PubMed ]
14 Gao B, Zhang Y, Ma L, Zhang XZ. [Effects of genistein on interleukin-1beta and tumor necrosis factor-alpha secreted by fibroblast-like synoviocytes isolated from type II collagen-induced arthritis rats]. Zhong Xi Yi Jie He Xue Bao. 2009; 7(7): 636-41[DOI][ PubMed ]
15 Gao X, Liu K, Huang F, Zhang D, Guo X, Wang M, et al. Positive and negative regulation of insulin action by genistein in the endothelium. J Nutr Biochem. 2013; 24(1): 222-30[DOI][ PubMed ]
16 Li H, Pan JS, Wang B. Inhibitive effect of genistein on interleukin-8 expression in cultured human retinal pigment epithelial cells. Methods Find Exp Clin Pharmacol. 2006; 28(5): 295-9[DOI][ PubMed ]
17 Xu YY, Yang C, Li SN. Effects of genistein on angiotensin-converting enzyme in rats. Life Sci. 2006; 79(9): 828-37[DOI][ PubMed ]
18 Hrenn A, Steinbrecher T, Labahn A, Schwager J, Schempp CM, Merfort I. Plant phenolics inhibit neutrophil elastase. Planta Med. 2006; 72(12): 1127-31[DOI][ PubMed ]
19 Ito K, Namikawa S, Takeuchi K. [Effect of the dry distillation tar of delipidated soybean (Glyteer) on a psoriasic model in the mouse (4)]. Nihon Yakurigaku Zasshi. 1992; 99(1): 55-62[ PubMed ]
20 Shyong EQ, Lu Y, Lazinsky A, Saladi RN, Phelps RG, Austin LM, et al. Effects of the isoflavone 4',5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage. Carcinogenesis. 2002; 23(2): 317-21[ PubMed ]
COMMENTS

LEAVE A COMMENT HERE: