Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Efficacy Evaluation of Nebulized Magnesium, as an Additional Complementary Treatment, in Clinical and Peak Flow Metric Improvements of Acute Asthma Attack: A Randomized Double-Blinded Clinical Trial

Hassan Motamed 1 , Mohammadreza Maleki Verki 1 , * , Mandana Pooladzade 1 and Alireza Majidi 2
Authors Information
1 Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Emergency Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: November 2017, 12 (4); e18420
  • Published Online: November 30, 2017
  • Article Type: Research Article
  • Received: June 13, 2017
  • Revised: July 4, 2017
  • Accepted: October 24, 2017
  • DOI: 10.5812/jjnpp.18420

To Cite: Motamed H, Maleki Verki M, Pooladzade M, Majidi A. Efficacy Evaluation of Nebulized Magnesium, as an Additional Complementary Treatment, in Clinical and Peak Flow Metric Improvements of Acute Asthma Attack: A Randomized Double-Blinded Clinical Trial, Jundishapur J Nat Pharm Prod. 2017 ; 12(4):e18420. doi: 10.5812/jjnpp.18420.

Copyright © 2017, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Mellis CM, Peat JK, Bauman AE, Woolcock AJ. The cost of asthma in New South Wales. Med J Aust. 1991;155(8):522-8. [PubMed: 1943931].
  • 2. Krahn MD, Berka C, Langlois P, Detsky AS. Direct and indirect costs of asthma in Canada, 1990. CMAJ. 1996;154(6):821-31. [PubMed: 8634960].
  • 3. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-78. doi: 10.1183/09031936.00138707. [PubMed: 18166595].
  • 4. Stoodley RG, Aaron SD, Dales RE. The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical trials. Ann Emerg Med. 1999;34(1):8-18. [PubMed: 10381989].
  • 5. Plotnick LH, Ducharme FM. Should inhaled anticholinergics be added to beta2 agonists for treating acute childhood and adolescent asthma? A systematic review. BMJ. 1998;317(7164):971-7. [PubMed: 9765164].
  • 6. Rodrigo GJ, Rodrigo C, Hall JB. Acute asthma in adults: a review. Chest. 2004;125(3):1081-102. [PubMed: 15006973].
  • 7. Shan Z, Rong Y, Yang W, Wang D, Yao P, Xie J, et al. Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis. Respir Med. 2013;107(3):321-30. doi: 10.1016/j.rmed.2012.12.001. [PubMed: 23290189].
  • 8. Britton J, Pavord I, Richards K, Wisniewski A, Knox A, Lewis S, et al. Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample. Lancet. 1994;344(8919):357-62. [PubMed: 7914305].
  • 9. Rosello HJ, Pla JC. Sulfato de magnesio en la crisis de asma. Prensa Med Argent. 1936;23:1677-80.
  • 10. Haury VG. Blood serum magnesium in bronchial asthma and its treatment by the administration of magnesium sulfate. J Lab Clin Med. 1940;26:340-4. doi: 10.1016/s0021-8707(41)80026-4.
  • 11. Okayama H, Aikawa T, Okayama M, Sasaki H, Mue S, Takishima T. Bronchodilating effect of intravenous magnesium sulfate in bronchial asthma. JAMA. 1987;257(8):1076-8. [PubMed: 3806898].
  • 12. Rolla G, Bucca C, Caria E, Arossa W, Bugiani M, Cesano L, et al. Acute effect of intravenous magnesium sulfate on airway obstruction of asthmatic patients. Ann Allergy. 1988;61(5):388-91. [PubMed: 3189965].
  • 13. Skobeloff EM, Spivey WH, McNamara RM, Greenspon L. Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. JAMA. 1989;262(9):1210-3. [PubMed: 2761061].
  • 14. Noppen M, Vanmaele L, Impens N, Schandevyl W. Bronchodilating effect of intravenous magnesium sulfate in acute severe bronchial asthma. Chest. 1990;97(2):373-6. [PubMed: 2298062].
  • 15. McNamara RM, Spivey WH, Skobeloff E, Jacubowitz S. Intravenous magnesium sulfate in the management of acute respiratory failure complicating asthma. Ann Emerg Med. 1989;18(2):197-9. [PubMed: 2916786].
  • 16. Kuitert LM, Kletchko SL. Intravenous magnesium sulfate in acute, life-threatening asthma. Ann Emerg Med. 1991;20(11):1243-5. [PubMed: 1952314].
  • 17. Sydow M, Crozier TA, Zielmann S, Radke J, Burchardi H. High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus. Intensive Care Med. 1993;19(8):467-71. [PubMed: 8294630].
  • 18. Okayama H, Okayama M, Aikawa T, Sasaki M, Takishima T. Treatment of status asthmaticus with intravenous magnesium sulfate. J Asthma. 1991;28(1):11-7. [PubMed: 2010425].
  • 19. Mills R, Leadbeater M, Ravalia A. Intravenous magnesium sulphate in the management of refractory bronchospasm in a ventilated asthmatic. Anaesthesia. 1997;52(8):782-5. [PubMed: 9291766].
  • 20. Green SM, Rothrock SG. Intravenous magnesium for acute asthma: failure to decrease emergency treatment duration or need for hospitalization. Ann Emerg Med. 1992;21(3):260-5. [PubMed: 1536485].
  • 21. Tiffany BR, Berk WA, Todd IK, White SR. Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations. Chest. 1993;104(3):831-4. [PubMed: 8365297].
  • 22. Bloch H, Silverman R, Mancherje N, Grant S, Jagminas L, Scharf SM. Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma. Chest. 1995;107(6):1576-81. [PubMed: 7781349].
  • 23. Skorodin MS, Tenholder MF, Yetter B, Owen KA, Waller RF, Khandelwahl S, et al. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Arch Intern Med. 1995;155(5):496-500. [PubMed: 7864705].
  • 24. Rolla G, Bucca C, Arossa W, Bugiani M. Magnesium attenuates methacholine-induced bronchoconstriction in asthmatics. Magnesium. 1987;6(4):201-4. [PubMed: 3669729].
  • 25. Rolla G, Bucca C, Bugiani M, Arossa W, Spinaci S. Reduction of histamine-induced bronchoconstriction by magnesium in asthmatic subjects. Allergy. 1987;42(3):186-8. [PubMed: 3592142].
  • 26. Nannini LJ, Hofer D. Effect of inhaled magnesium sulfate on sodium metabisulfite-induced bronchoconstriction in asthma. Chest. 1997;111(4):858-61. [PubMed: 9106560].
  • 27. Nannini LJ, Pendino JC, Corna RA, Mannarino S, Quispe R. Magnesium sulfate as a vehicle for nebulized salbutamol in acute asthma. Am J Med. 2000;108(3):193-7. [PubMed: 10723972].
  • 28. Porter RS, Braitman LE, Geary U, Dalsey WC.Nester. Intravenous magnesium is ineffective in adult asthma, a randomized trial. Eur J Emerg Med. 2001;8(1):9-15. [PubMed: 11314826].
  • 29. Aggarwal P, Sharad S, Handa R, Dwiwedi SN, Irshad M. Comparison of nebulised magnesium sulphate and salbutamol combined with salbutamol alone in the treatment of acute bronchial asthma: a randomised study. Emerg Med J. 2006;23(5):358-62. doi: 10.1136/emj.2005.026203. [PubMed: 16627836].
  • 30. Goodacre S, Cohen J, Bradburn M, Stevens J, Gray A, Benger J, et al. The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technol Assess. 2014;18(22):1-168. doi: 10.3310/hta18220. [PubMed: 24731521].
  • 31. Mahajan P, Haritos D, Rosenberg N, Thomas R. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med. 2004;27(1):21-5. doi: 10.1016/j.jemermed.2004.02.006. [PubMed: 15219299].
  • 32. Altura BM, Altura BT. Magnesium and contraction of arterial smooth muscle. Microvasc Res. 1974;7(2):145-55. [PubMed: 4363012].
  • 33. Spivey WH, Skobeloff EM, Levin RM. Effect of magnesium chloride on rabbit bronchial smooth muscle. Ann Emerg Med. 1990;19(10):1107-12. [PubMed: 1977337].
  • 34. Blitz M, Blitz S, Beasely R, Diner B, Hughes R, Knopp JA, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2005;(3):3898. doi: 10.1002/14651858.CD003898.pub3. [PubMed: 16034914].
  • 35. Reinhart RA. Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels. Arch Intern Med. 1988;148(11):2415-20. [PubMed: 3056314].
  • 36. Bodenhamer J, Bergstrom R, Brown D, Gabow P, Marx JA, Lowenstein SR. Frequently nebulized beta-agonists for asthma: effects on serum electrolytes. Ann Emerg Med. 1992;21(11):1337-42. [PubMed: 1416329].
  • 37. Thorp JJ, Katz VL, Campbell D, Cefalo RC. Hypersensitivity to magnesium sulfate. Am J Obstet Gynecol. 1989;161(4):889-90. [PubMed: 2801834].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments