Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Hypnotic Effect of Nepeta glomerulosa on Pentobarbital-Induced Sleep in Mice

Azar Hosseini 1 , Fatemeh Forouzanfar 2 , 3 and Hassan Rakhshandeh 1 , 3 , *
Authors Information
1 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 01, 2016, 11 (1); e25063
  • Published Online: February 20, 2016
  • Article Type: Research Article
  • Received: November 1, 2014
  • Revised: June 13, 2015
  • Accepted: July 15, 2015
  • DOI: 10.17795/jjnpp-25063

To Cite: Hosseini A, Forouzanfar F, Rakhshandeh H. Hypnotic Effect of Nepeta glomerulosa on Pentobarbital-Induced Sleep in Mice, Jundishapur J Nat Pharm Prod. 2016 ; 11(1):e25063. doi: 10.17795/jjnpp-25063.

Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Dey A, Dey A. Phytotherapy against insomnia: Extravagant claims or an alternative medicine? Pak J Biol Sci. 2013; 16(3): 148-50[DOI][PubMed]
  • 2. Orzel-Gryglewska J. Consequences of sleep deprivation. Int J Occup Med Environ Health. 2010; 23(1): 95-114[DOI][PubMed]
  • 3. Zaharna M, Guilleminault C. Sleep, noise and health: review. Noise Health. 2010; 12(47): 64-9[DOI][PubMed]
  • 4. McPherson F, McGraw L. Treating generalized anxiety disorder using complementary and alternative medicine. Altern Ther Health Med. 2013; 19(5): 45-50[PubMed]
  • 5. Cho SM, Shimizu M, Lee CJ, Han DS, Jung CK, Jo JH, et al. Hypnotic effects and binding studies for GABA(A) and 5-HT(2C) receptors of traditional medicinal plants used in Asia for insomnia. J Ethnopharmacol. 2010; 132(1): 225-32[DOI][PubMed]
  • 6. Roth T, Drake C. Evolution of insomnia: current status and future direction. Sleep Medicine. 2004; 5-30[DOI][PubMed]
  • 7. Phillipson JD. Phytochemistry and medicinal plants. Phytochemistry. 2001; 56(3): 237-43[DOI][PubMed]
  • 8. Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav. 2003; 75(3): 501-12[DOI][PubMed]
  • 9. Aydin S, Demir T, Ozturk Y, Baser KHC. Analgesic activity ofNepeta italica l. Phytotherapy Research. 1999; 13(1): 20-3[DOI][PubMed]
  • 10. Sonboli A, Salehi P, Yousefzadi M. Antimicrobial activity and chemical composition of the essential oil of Nepeta crispa Willd. from Iran. Z Naturforsch C Bio Sci. 2004; 59(9-10): 653-6
  • 11. Aydin S, Beis R, Ozturk Y, Baser KH. Nepetalactone: a new opioid analgesic from Nepeta caesarea Boiss. J Pharm Pharmacol. 1998; 50(7): 813-7[PubMed]
  • 12. Ganzera M, Crockett S, Tellez MR, Khan IA. Determination of nepetalactone in Nepeta cataria by reversed phase high performance liquid chromatography. Pharmazie. 2001; 56(11): 896-7[PubMed]
  • 13. Fazly Bazzaz BS, Haririzadeh G, Imami SA, Rashed MH. Survey of Iranian Plants for Alkaloids, Flavonoids, Saponins, and Tannins [Khorasan Province]. Pharmaceutical Biology. 1997; 35(1): 17-30[DOI]
  • 14. Sajjadi SE, Ghassemi N. Volatile constituents of Nepeta glomerulosa Boiss. subsp. carmanica. Flavour Frag J. 1999; 14(5): 265-7
  • 15. Sefidkon F. Essential Oil ofNepeta glomerulosaBoiss. from Iran. J ESSENT OIL RES. 2001; 13(6): 422-3[DOI]
  • 16. Hosseinzadeh H, Ziaee T. Effect of Nepeta glomerulosa Boiss. Aerial parts aqueous extract on morphine withdrawal syndrome in mice. Iran J Pharm Sci. 2006; 2(1): 41-6
  • 17. Bozorgmehr FM, M Faizi B. Evaluation of sedative-hypnotic effect of ethanolic extract of five medicinal plants; Nepeta menthoides, Matricaria chamomilla, Asperugo procumbens, Lippia citriodora and Withania somnifera. Curr Res Pharm Sci. 2012; 7(5)
  • 18. Oliaee D, Boroushaki MT, Oliaee N, Ghorbani A. Evaluation of cytotoxicity and antifertility effect of artemisia kopetdaghensis. Adv Pharmacol Sci. 2014; 2014: 745-60
  • 19. Ghorbani A, Rakhshandeh H, Asadpour E, Sadeghnia HR. Effects of Coriandrum sativum extracts on glucose/serum deprivation-induced neuronal cell death. Avicenna J Phytomed. 2011; 2(1): 4-9
  • 20. Rakhshandeh H, Sadeghnia H. R., Ghorbani A. Sleep-prolonging effect of Coriandrum sativum hydro-alcoholic extract in mice. Nat Prod Res. 2012; 26(22): 2095-8[PubMed]
  • 21. Raj J, Chandra M, Dogra TD, Pahuja M, Raina A. Determination of median lethal dose of combination of endosulfan and cypermethrin in wistar rat. Toxicol Int. 2013; 20(1): 1-5[DOI][PubMed]
  • 22. Hadjzadeh M, Tavakol Afshari J, Ghorbani A, Shakeri MT. The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro. J Med Plants . 2006; 2(18): 41-8
  • 23. Zhang D, Li H, Wang JB. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity. Int J Biol Macromol. 2015; 72: 243-53[PubMed]
  • 24. Huang F, Xiong Y, Xu L, Ma S, Dou C. Sedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and rats. J Ethnopharmacol. 2007; 110(3): 471-5[DOI][PubMed]
  • 25. Herrera-Ruiz M, Gutierrez C, Enrique Jimenez-Ferrer J, Tortoriello J, Miron G, Leon I. Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots. J Ethnopharmacol. 2007; 112(2): 243-7[DOI][PubMed]
  • 26. Alnamer R, Alaoui K, Bouidida el H, Benjouad A, Cherrah Y. Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco. Adv Pharmacol Sci. 2012; 2012: 270824[DOI][PubMed]
  • 27. Sharma M, Rauniar GP, Das BP. Experimental study of various central nervous system effects of eugenol in mice and rats. Health Renaissance. 2012; 10(3)[DOI]
  • 28. Linck VM, da Silva AL, Figueiro M, Piato AL, Herrmann AP, Dupont Birck F, et al. Inhaled linalool-induced sedation in mice. Phytomedicine. 2009; 16(4): 303-7[DOI][PubMed]
  • 29. Galati EM, Miceli N, Galluzzo M, Taviano MF, Tzakou O. Neuropharmacological Effects of Epinepetalactone fromNepeta sibthorpiiBehavioral and Anticonvulsant Activity. Pharmaceutical Biology. 2004; 42(6): 391-5[DOI]
  • 30. Taviano MF, Miceli N, Monforte MT, Tzakou O, Galati E. Phytother Res. 2007; 21(4): 382-5[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments