Jundishapur Journal of Natural Pharmaceutical Products

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Growth Inhibition and Apoptosis Induction by Vincetoxicum pumilum Decne. on HL-60 and K562 Leukemic Cell Lines

Zahra Tayarani Najaran 1 , Seyed Hadi Mousavi 2 , 3 , Marzieh Rasoulinejad 1 , Javad Asili 4 , Milad Iranshahy 4 and Seyed Ahmad Emami 4 , *
Authors Information
1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: May 01, 2016, 11 (2); e29370
  • Published Online: May 11, 2016
  • Article Type: Research Article
  • Received: April 22, 2015
  • Accepted: March 14, 2016
  • DOI: 10.17795/jjnpp-29370

To Cite: Tayarani Najaran Z, Mousavi S H, Rasoulinejad M, Asili J, Iranshahy M, et al. Growth Inhibition and Apoptosis Induction by Vincetoxicum pumilum Decne. on HL-60 and K562 Leukemic Cell Lines, Jundishapur J Nat Pharm Prod. 2016 ; 11(2):e29370. doi: 10.17795/jjnpp-29370.

Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Fernandez-Luna J. Apoptosis regulators as targets for cancer therapy. Clin Transl Onco. 2007; 9(9): 555-62[DOI]
  • 2. Mehta RG, Murillo G, Naithani R, Peng X. Cancer chemoprevention by natural products: how far have we come? Pharm Res. 2010; 27(6): 950-61[DOI][PubMed]
  • 3. Zaeifi M. Two new species of genus Vincetoxicum (Asclepiadaceae) from Iran. Iran J Bot. 1999; 8(1): 105-10
  • 4. Zaeifi M. Asclepiadaceae. 2000;
  • 5. Emami S, Aghazari F. Les Phanerogames Endemiques de la Flore d Iran. 2011;
  • 6. Zadina R, Kraus L. [Pharmacology of Vincetoxicum officinale Moench]. Cesk Farm. 1954; 3(7): 235-8[PubMed]
  • 7. Mogg C, Petit P, Cappuccino N, Durst T, McKague C, Foster M, et al. Tests of the antibiotic properties of invasive vine Vincetoxicum rossicum against bacteria, fungi and insects. Biochem Syst Ecol. 2008; 36(5): 383-91[DOI]
  • 8. Mansoor A, Ibrahim MA, Zaidi MA, Ahmed M. Anti-protozoal activities of Vincetoxicum stocksii and Carum copticum. Bangladesh J Pharmacol. 2011; 6(1): 51-4[DOI]
  • 9. Shah A, Zaidi MA, Sajjad H, Hamidullaha Gilani AH. Anti-diarrheal and anti-spasmodic activities of Vincetoxicum stocksii are mediated through calcium channel blockade. Bangladesh J Pharmacol. 2011; 6(1): 46-50[DOI]
  • 10. Zaidi MA, Crow SJ. Biologically active traditional medicinal herbs from Balochistan, Pakistan. J Ethnopharmacol. 2005; 96(1-2): 331-4[DOI][PubMed]
  • 11. Sliumpaite I, Murkovic M, Zeb A, Venskutonis PR. Anti-oxidant properties and phenolic composition of swallow wort (Vincetoxicum lutea L). leaf Ind Crops Prod. 2013; 45(1): 74-82[DOI]
  • 12. Stockel K, Stocklin W, Reichstein T. [The glycosides of Vincetoxicum hirundinaria Medikus. I. Isolation and cleavage product (glycosides and aglycones)]. Helv Chim Acta. 1969; 52(5): 1175-202[DOI][PubMed]
  • 13. Kozjek F, Lebreton P, Mabry TJ, Markham KR, Yoshioka H, Netien G. [Flavonoid heterosides of Vincetoxicum officinale Moench, Axclepiadaceae]. Ann Pharm Fr. 1968; 26(7): 513-22[PubMed]
  • 14. Kozjek F, Lebreton P. [On 2 new natural heterosides of quercetin, extracted from Vincetoxicum officinale Moench]. C R Acad Sci Hebd Seances Acad Sci D. 1967; 264(20): 2409-11[PubMed]
  • 15. Malkia A, Murtomaki L, Urtti A, Kontturi K. Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties. Eur J Pharm Sci. 2004; 23(1): 13-47[DOI][PubMed]
  • 16. Staerk D, Bahrami Nezhad K, Asili J, Emami SA, Ahi A, Sairafianpour M, et al. Phenanthroindolizidine alkaloids from Vincetoxicum pumilum. Bioch Sys Ecol. 2005; 33(9): 957-60[DOI]
  • 17. Staerk D, Lykkeberg AK, Christensen J, Budnik BA, Abe F, Jaroszewski JW. In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. J Nat Prod. 2002; 65(9): 1299-302[PubMed]
  • 18. O'Brien J, Wilson I, Orton T, Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem. 2000; 267(17): 5421-6[PubMed]
  • 19. Tayarani-Najaran Z, Mousavi SH, Asili J, Emami SA. Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines. Food Chem Toxicol. 2010; 48(2): 599-604[DOI][PubMed]
  • 20. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 1991; 13(2): 271-9[DOI]
  • 21. Suzuki M, Youle RJ, Tjandra N. Structure of Bax, co-regulation of dimer forma-tion, and intracellular localization. Cell. 2000; 103(1): 645-54[DOI]
  • 22. Zhang X, Chen LX, Ouyang L, Cheng Y, Liu B. Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif. 2012; 45(5): 466-76[DOI][PubMed]
  • 23. Shu L, Cheung KL, Khor TO, Chen C, Kong AN. Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 2010; 29(3): 483-502[DOI][PubMed]
  • 24. Otsuka H. Purification by solvent extraction using partition coefficient. 2006;
  • 25. Tanner U, Wiegrebe W. Alkaloids of Cynanchum vincetoxicum: efficacy against MDA-MB-231 mammary carcinoma cells. Arch Pharm. 1993; 36(2): 67-72[DOI]
  • 26. Gao W, Lam W, Zhong S, Kaczmarek C, Baker DC, Cheng YC. Novel mode of action of tylophorine analogs as antitumor compounds. Cancer Res. 2004; 64(2): 678-88[PubMed]
  • 27. Yang CW, Chen WL, Wu PL, Tseng HY, Lee SJ. Anti-inflammatory mechanisms of phenanthroindolizidine alkaloids. Mol Pharmacol. 2006; 69(3): 749-58[DOI][PubMed]
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