Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats

Annahita Rezaie 1 , * , Ali Fazlara 2 , Mojtaba Haghi Karamolah 2 , Ali Shahriari 3 , Hossein Najaf Zadeh 3 and Marzieh Pashmforosh 4 , 5
Authors Information
1 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IR Iran
2 Department of food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IR Iran
3 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IR Iran
4 School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
5 Research Committee, Jundishapur University of Medical Science, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: June 10, 2013, 8 (2); 60-64
  • Published Online: May 4, 2013
  • Article Type: Research Article
  • Received: December 16, 2012
  • Revised: February 3, 2013
  • Accepted: February 12, 2013
  • DOI: 10.17795/jjnpp-9686

To Cite: Rezaie A, Fazlara A, Haghi Karamolah M, Shahriari A, Najaf Zadeh H, et al. Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats, Jundishapur J Nat Pharm Prod. 2013 ; 8(2):60-64. doi: 10.17795/jjnpp-9686.

Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Thirunavukkarasu C, Sakthisekaran D. Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors. Pharmacol Res. 2003; 48(2): 167-73[DOI][PubMed]
  • 2. Verna L, Whysner J, Williams GM. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther. 1996; 71(1-2): 57-81[DOI][PubMed]
  • 3. Farombi EO, Shrotriya S, Surh YJ. Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1. Life Sci. 2009; 84(5-6): 149-55[DOI][PubMed]
  • 4. Pradeep K, Mohan CV, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2007; 560(2-3): 110-6[DOI][PubMed]
  • 5. Pradeep K, Raj Mohan CV, Gobianand K, Karthikeyan S. Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats. Biol Res. 2010; 43(1): 113-25[DOI][PubMed]
  • 6. Abdullah T. A strategic call to utilize Echinacea-garlic in flu-cold seasons. J Natl Med Assoc. 2000; 92(1): 48-51[PubMed]
  • 7. Bauer VR, Jurcic K, Puhlmann J, Wagner H. [Immunologic in vivo and in vitro studies on Echinacea extracts]. Arzneimittelforschung. 1988; 38(2): 276-81[PubMed]
  • 8. Tanaka T, Kojima T, Kawamori T, Yoshimi N, Mori H. Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats. Cancer Res. 1993; 53(12): 2775-9[PubMed]
  • 9. Roesler J, Emmendorffer A, Steinmuller C, Luettig B, Wagner H, Lohmann-Matthes ML. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int J Immunopharmacol. 1991; 13(7): 931-41[DOI][PubMed]
  • 10. Luettig B, Steinmuller C, Gifford GE, Wagner H, Lohmann-Matthes ML. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst. 1989; 81(9): 669-75[DOI][PubMed]
  • 11. Braunig B, Dorn M, Limburg EE. Enhancement of resistance in common cold by Echinacea purpurea. Z Phytother. 1992; 13: 7-13
  • 12. Murray M. The Healing Power of Herbs. 1995; : 357-8
  • 13. Heidari M, Rezaie A, Pourmahdi Broojeni M, Najafzadeh H, Mohammadian B. Histopathologic effects of Echinacea purpurea extract on sodium arsenite-induced hepatic disorders. Comp Clin Pathol. 2012; 21(6): 1629-32[DOI]
  • 14. El-Shahat M, El-Abd S, Alkafafy M, El-Khatib G. Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa). Acta Histochem. 2012; 114(5): 421-8[DOI][PubMed]
  • 15. Shahjahan M, Vani G, Shyamaladevi CS. Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat. Chem Biol Interact. 2005; 156(2-3): 113-23[DOI][PubMed]
  • 16. Sun H, Yu L, Wei H, Liu G. A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. J Biomed Biotechnol. 2012; 2012: 584728[DOI][PubMed]
  • 17. Liao DJ, Blanck A, Eneroth P, Gustafsson JA, Hallstrom IP. Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat. Environ Health Perspect. 2001; 109(9): 943-7[DOI][PubMed]
  • 18. Sadik NAH, EL-Maraghy SA, Ismail MF. Diethylnitrosamine-induced hepatocarcinogenesis in rats: possible chemoprevention by blueberries. Afr J Biochem Res. 2008; 2(3): 81-7
  • 19. Kang JS, Wanibuchi H, Morimura K, Gonzalez FJ, Fukushima S. Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res. 2007; 67(23): 11141-6[DOI][PubMed]
  • 20. Ahmad R, Ahmed S, Khan NU, Hasnain AU. Operculina turpethum attenuates N-nitrosodimethylamine induced toxic liver injury and clastogenicity in rats. Chem Biol Interact. 2009; 181(2): 145-53[DOI][PubMed]
  • 21. George J, Tsutsumi M. siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats. Gene Ther. 2007; 14(10): 790-803[DOI][PubMed]
  • 22. Bayramoglu G, Kabay S, Ozden H, Ustuner MC, Uysal O, Bayramoglu A, et al. The effect of Echinacea on kidney and liver after experimental renal ischemia/reperfusion injury in the rats. Afr J Pharm Pharmacol. 2011; 5: 1561-6
  • 23. Ali EH. Protective effects of Echinacea on cyproterone acetate induced liver damage in male rats. Pak J Biol Sci. 2008; 11(21): 2464-71[DOI][PubMed]
  • 24. Ezz MK. The Ameliorative Effect of Echinacea Purpurea Against Gamma Radiation Induced Oxidative Stress and Immune Responses in Male Rats. Aust J Basic Appl Sci. 2011; 5(10): 506-12
  • 25. Pellati F, Benvenuti S, Melegari M, Lasseigne T. Variability in the composition of anti-oxidant compounds in Echinacea species by HPLC. Phytochem Anal. 2005; 16(2): 77-85[DOI][PubMed]
  • 26. Stanisavljević I, Stojičević S, Veličković D, Veljković V, Lazić M. Antioxidant and Antimicrobial Activities of Echinacea (Echinacea purpurea L.) Extracts Obtained by Classical and Ultrasound Extraction. Chinese J Chem Eng. 2009; 17(3): 478-83[DOI]
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