Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Vitamin E and Omega-3, 6 and 9 Combinations Versus Vitamin E in the Treatment of Mastodynia

Bahram Delfan 1 , Farshad Zarei 2 , Somayeh Iravani 2 , Farzad Ebrahimzadeh 3 , Ahmad Adineh 4 , * , Reza Sepahvand 4 and Mohsen Asadbaigi 4
Authors Information
1 Department of Pharmacology, Lorestan University of Medical Sciences, Khorramabad, IR Iran
2 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, IR Iran
3 Department of Statistics, Lorestan University of Medical Sciences, Khorramabad, IR Iran
4 Deputy of FDO, Lorestan University of Medical Sciences, Khorramabad, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: May 01, 2015, 10 (2); e18659
  • Published Online: May 20, 2015
  • Article Type: Research Article
  • Received: March 4, 2014
  • Revised: July 15, 2014
  • Accepted: September 23, 2014
  • DOI: 10.17795/jjnpp-18659

To Cite: Delfan B, Zarei F, Iravani S, Ebrahimzadeh F, Adineh A, et al. Vitamin E and Omega-3, 6 and 9 Combinations Versus Vitamin E in the Treatment of Mastodynia, Jundishapur J Nat Pharm Prod. 2015 ; 10(2):e18659. doi: 10.17795/jjnpp-18659.

Copyright © 2015, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Ader DN, Shriver CD. Cyclical mastalgia: prevalence and impact in an outpatient breast clinic sample. J Am Coll Surg. 1997; 185(5): 466-70[PubMed]
  • 2. Smith RL, Pruthi S, Fitzpatrick LA. Evaluation and management of breast pain. Mayo Clin Proc. 2004; 79(3): 353-72[DOI][PubMed]
  • 3. Kataria K, Dhar A, Srivastava A, Kumar S, Goyal A. A systematic review of current understanding and management of mastalgia. Indian J Surg. 2014; 76(3): 217-22[DOI][PubMed]
  • 4. Srivastava A, Mansel RE, Arvind N, Prasad K, Dhar A, Chabra A. Evidence-based management of Mastalgia: a meta-analysis of randomised trials. Breast. 2007; 16(5): 503-12[DOI][PubMed]
  • 5. Ahmadinejad M, Delfan B, Haghdani S, Hashemi M, Khan IA, Tafti MT. Comparing the effect of diclofenac gel and piroxicam gel on mastalgia. Breast J. 2010; 16(2): 213-4[DOI][PubMed]
  • 6. Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast J. 2009; 15(5): 510-4[DOI][PubMed]
  • 7. Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Altern Med Rev. 2010; 15(1): 59-67[PubMed]
  • 8. Ernster VL, Goodson W3, Hunt TK, Petrakis NL, Sickles EA, Miike R. Vitamin E and benign breast "disease": a double-blind, randomized clinical trial. Surgery. 1985; 97(4): 490-4[PubMed]
  • 9. London RS, Sundaram GS, Murphy L, Manimekalai S, Reynolds M, Goldstein PJ. The effect of vitamin E on mammary dysplasia: a double-blind study. Obstet Gynecol. 1985; 65(1): 104-6[PubMed]
  • 10. Meyer EC, Sommers DK, Reitz CJ, Mentis H. Vitamin E and benign breast disease. Surgery. 1990; 107(5): 549-51[PubMed]
  • 11. Cheung KL. Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia. Aust N Z J Surg. 1999; 69(7): 492-4[PubMed]
  • 12. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc. 2000; 100(11): 1368-80[DOI][PubMed]
  • 13. Goyal A, Mansel RE, Efamast Study G. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Breast J. 2005; 11(1): 41-7[DOI][PubMed]
  • 14. Blommers J, de Lange-De Klerk ES, Kuik DJ, Bezemer PD, Meijer S. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Am J Obstet Gynecol. 2002; 187(5): 1389-94[PubMed]
  • 15. Horrobin DF, Manku MS. Premenstrual syndrome and premenstrual breast pain (cyclical mastalgia): disorders of essential fatty acid (EFA) metabolism. Prostaglandins Leukot Essent Fatty Acids. 1989; 37(4): 255-61[PubMed]
  • 16. Horrobin DF, Manku MS, Brush M, Callender K, Preece PE, Mansel RE. Abnormalities in plasma essential fatty acid levels in women with premenstrual syndrome and with non-malignant breast disease. J Nutr Env Med. 1991; 2(3): 259-64
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