Jundishapur Journal of Natural Pharmaceutical Products

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Evaluation of the Effect of Naringenin on Pentylenetetrazole and Maximal Electroshock-Induced Convulsions in Mice

Mohammad Javad Khodayar 1 , 2 , 3 , * , Saeed Salehi 1 , Mohsen Rezaei 4 , Amir Siahpoosh 2 , 5 , Ahad Khazaei 1 and Gholamreza Houshmand 1
Authors Information
1 Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Medicinal Plants and Natural Products Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
4 Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
5 Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 2017, 12 (1); e31384
  • Published Online: October 2, 2016
  • Article Type: Research Article
  • Received: August 2, 2015
  • Revised: July 7, 2016
  • Accepted: September 13, 2016
  • DOI: 10.5812/jjnpp.31384

To Cite: Khodayar M J, Salehi S, Rezaei M, Siahpoosh A, Khazaei A, et al. Evaluation of the Effect of Naringenin on Pentylenetetrazole and Maximal Electroshock-Induced Convulsions in Mice, Jundishapur J Nat Pharm Prod. 2017 ; 12(1):e31384. doi: 10.5812/jjnpp.31384.

Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Gourie-Devi M, Gururaj G, Satishchandra P, Subbakrishna DK. Prevalence of neurological disorders in Bangalore, India: a community-based study with a comparison between urban and rural areas. Neuroepidemiology. 2004; 23(6): 261-8[DOI][PubMed]
  • 2. de Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav. 2008; 12(4): 540-6[DOI][PubMed]
  • 3. Leonard BE. Fundamentals of psychopharmacology. 2004;
  • 4. Smith MC, Bleck TP. Convulsive disorders: toxicity of anticonvulsants. Clin Neuropharmacol. 1991; 14(2): 97-115[PubMed]
  • 5. Rang HP, Ritter JM, Flower RJ, Henderson G. Rang & Dale's Pharmacology: With student consult online access. 2014;
  • 6. Schachter SC. Botanicals and herbs: a traditional approach to treating epilepsy. Neurotherapeutics. 2009; 6(2): 415-20[DOI][PubMed]
  • 7. Vafeiadou K, Vauzour D, Lee HY, Rodriguez-Mateos A, Williams RJ, Spencer JP. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys. 2009; 484(1): 100-9[DOI][PubMed]
  • 8. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996; 20(7): 933-56[PubMed]
  • 9. Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005; 39(10): 1119-25[DOI][PubMed]
  • 10. Olsen HT, Stafford GI, van Staden J, Christensen SB, Jager AK. Isolation of the MAO-inhibitor naringenin from Mentha aquatica L. J Ethnopharmacol. 2008; 117(3): 500-2[DOI][PubMed]
  • 11. Shi Y, Dai J, Liu H, Li RR, Sun PL, Du Q, et al. Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-kappaB activity in a murine model of asthma. Can J Physiol Pharmacol. 2009; 87(9): 729-35[DOI][PubMed]
  • 12. Spencer JP. Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc. 2008; 67(2): 238-52[DOI][PubMed]
  • 13. Raza SS, Khan MM, Ahmad A, Ashafaq M, Islam F, Wagner AP, et al. Neuroprotective effect of naringenin is mediated through suppression of NF-kappaB signaling pathway in experimental stroke. Neuroscience. 2013; 230: 157-71[DOI][PubMed]
  • 14. Baluchnejadmojarad T, Roghani M. Effect of naringenin on intracerebroventricular streptozotocin-induced cognitive deficits in rat: a behavioral analysis. Pharmacology. 2006; 78(4): 193-7[DOI][PubMed]
  • 15. Mercer LD, Kelly BL, Horne MK, Beart PM. Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol. 2005; 69(2): 339-45[DOI][PubMed]
  • 16. Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong B, et al. Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia. Dement Geriatr Cogn Disord. 2004; 17(3): 151-7[DOI][PubMed]
  • 17. Luszczki JJ, Glowniak K, Czuczwar SJ. Time-course and dose-response relationships of imperatorin in the mouse maximal electroshock seizure threshold model. Neurosci Res. 2007; 59(1): 18-22[DOI][PubMed]
  • 18. Sayyah M, Mandgary A, Kamalinejad M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J Ethnopharmacol. 2002; 82(2): 105-9
  • 19. Sitges M, Chiu LM, Reed RC. Effects of Levetiracetam, Carbamazepine, Phenytoin, Valproate, Lamotrigine, Oxcarbazepine, Topiramate, Vinpocetine and Sertraline on Presynaptic Hippocampal Na(+) and Ca(2+) Channels Permeability. Neurochem Res. 2016; 41(4): 758-69[DOI][PubMed]
  • 20. Loscher W, Fassbender CP, Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res. 1991; 8(2): 79-94[PubMed]
  • 21. Peterson SL. Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. Brain Res Bull. 1991; 26(1): 43-7[PubMed]
  • 22. Loscher W, Honack D, Fassbender CP, Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res. 1991; 8(3): 171-89[PubMed]
  • 23. Namvaran AA, Tavakkoli GF. The effect of Salvia officinalis hydroalcoholic extract on PTZ-induced seizure threshold in Vincristine injected mice. 2012; 13: 47-55
  • 24. Fisher A, Walker M, Bowery N. Mechanisms of action of antiepileptic drugs. Epilepsy: From synapse to society. A practical guide to epilepsy. . 2003; : 249-72
  • 25. Jager AK, Gauguin B, Adsersen A, Gudiksen L. Screening of plants used in Danish folk medicine to treat epilepsy and convulsions. J Ethnopharmacol. 2006; 105(1-2): 294-300[DOI][PubMed]
  • 26. Salah SM, Jager AK. Screening of traditionally used Lebanese herbs for neurological activities. J Ethnopharmacol. 2005; 97(1): 145-9[DOI][PubMed]
  • 27. Golechha M, Chaudhry U, Bhatia J, Saluja D, Arya DS. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol Pharm Bull. 2011; 34(3): 360-5[PubMed]
  • 28. Ribeiro IA, Rocha J, Sepodes B, Mota-Filipe H, Ribeiro MH. Effect of naringin enzymatic hydrolysis towards naringenin on the anti-inflammatory activity of both compounds. J Mol Catal B Enzym. 2008; 52: 13-8
  • 29. Rice-Evans C. Flavonoid antioxidants. Curr Med Chem. 2001; 8(7): 797-807[PubMed]
  • 30. Jesberger JA, Richardson JS. Oxygen free radicals and brain dysfunction. Int J Neurosci. 1991; 57(1-2): 1-17[PubMed]
  • 31. Kunz WS. The role of mitochondria in epileptogenesis. Curr Opin Neurol. 2002; 15(2): 179-84[PubMed]
  • 32. Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci U S A. 1990; 87(13): 5144-7[PubMed]
  • 33. Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology. 2005; 49(4): 456-64[DOI][PubMed]
  • 34. Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care. 2007; 30(6): 1406-11[DOI][PubMed]
  • 35. Heo HJ, Kim DO, Shin SC, Kim MJ, Kim BG, Shin DH. Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection. J Agric Food Chem. 2004; 52(6): 1520-5[DOI][PubMed]
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