Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines

Masoud Pourali 1 , Mohammad Mehdi Yaghoobi 2 , * and Mohammad Hosein Salehi Sormaghi 3
Authors Information
1 Department of Biotechnology, Graduate University of Advanced Technology, Kerman, Iran
2 Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
3 Department of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: May 2017, 12 (2); e33561
  • Published Online: October 8, 2016
  • Article Type: Research Article
  • Received: October 3, 2015
  • Revised: August 25, 2016
  • Accepted: September 14, 2016
  • DOI: 10.5812/jjnpp.33561

To Cite: Pourali M, Yaghoobi M M, Salehi Sormaghi M H. Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines, Jundishapur J Nat Pharm Prod. 2017 ; 12(2):e33561. doi: 10.5812/jjnpp.33561.

Abstract
Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
References
  • 1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015; 65(1): 5-29[DOI][PubMed]
  • 2. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012; 75(3): 311-35[DOI][PubMed]
  • 3. Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S. Phytopharmacological overview of Tribulus terrestris. Pharmacogn Rev. 2014; 8(15): 45-51[DOI][PubMed]
  • 4. Sisto M, Lisi S, D'Amore M, De Lucro R, Carati D, Castellana D, et al. Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage. J Photochem Photobiol B. 2012; 117: 193-201[DOI][PubMed]
  • 5. Bedir E, Khan IA, Walker LA. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie. 2002; 57(7): 491-3[PubMed]
  • 6. Ivanova A, Serly J, Dinchev D, Ocsovszki I, Kostova I, Molnar J. Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators. In Vivo. 2009; 23(4): 545-50[PubMed]
  • 7. Neychev VK, Nikolova E, Zhelev N, Mitev VI. Saponins from Tribulus terrestris L are less toxic for normal human fibroblasts than for many cancer lines: influence on apoptosis and proliferation. Exp Biol Med (Maywood). 2007; 232(1): 126-33[PubMed]
  • 8. Kim HJ, Kim JC, Min JS, Kim MJ, Kim JA, Kor MH, et al. Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-kappaB signaling in liver cancer cells. J Ethnopharmacol. 2011; 136(1): 197-203[DOI][PubMed]
  • 9. Sun B, Qu W, Bai Z. The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro [ in Chinese ]. Zhong Yao Cai. 2003; 26(2): 104-6[PubMed]
  • 10. Sun B, Qu WJ, Zhang XL, Yang HJ, Zhuang XY, Zhang P. Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402 [ in Chinese ]. Zhongguo Zhong Yao Za Zhi. 2004; 29(7): 681-4[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments