Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

The Effects of Cinnamomum zeylanicum on Lipid Profiles and Histology Via Up-Regulation of LDL Receptor Gene Expression in Hamsters Fed a High Cholesterol Diet

Seyed Mehrdad Kassaee 1 , Mohammad Taghi Goodarzi 2 , * , Nasim Hayati Roodbari 1 and Parichehr Yaghmaei 1
Authors Information
1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, IR Iran
2 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2017, 12 (3); e37340
  • Published Online: August 31, 2016
  • Article Type: Research Article
  • Received: February 22, 2016
  • Revised: April 9, 2016
  • Accepted: June 28, 2016
  • DOI: 10.5812/jjnpp.37340

To Cite: Kassaee S M, Goodarzi M T, Hayati Roodbari N, Yaghmaei P. The Effects of Cinnamomum zeylanicum on Lipid Profiles and Histology Via Up-Regulation of LDL Receptor Gene Expression in Hamsters Fed a High Cholesterol Diet, Jundishapur J Nat Pharm Prod. 2017 ; 12(3):e37340. doi: 10.5812/jjnpp.37340.

Abstract
Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
References
  • 1. Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care. 2013; 40(1): 195-211[DOI][PubMed]
  • 2. Mathur M, Kusum Devi V. Potential of novel drug delivery strategies for the treatment of hyperlipidemia. J Drug Target. 2016; : 1-11[DOI][PubMed]
  • 3. Mohammadi A, Bazrafshani MR, Oshaghi EA. Effect of garlic extract on some serum biochemical parameters and expression of npc1l1, abca1, abcg5 and abcg8 genes in the intestine of hypercholesterolemic mice. Indian J Biochem Biophys. 2013; 50(6): 500-4[PubMed]
  • 4. Tavoosi Z, Moradi-Sardareh H, Saidijam M, Yadegarazari R, Borzuei S, Soltanian A, et al. Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome. Cholesterol. 2015; 2015: 682904[DOI][PubMed]
  • 5. Sham TT, Chan CO, Wang YH, Yang JM, Mok DK, Chan SW. A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect. Biomed Res Int. 2014; 2014: 925302[DOI][PubMed]
  • 6. Belguith-Hadriche O, Bouaziz M, Jamoussi K, Simmonds MS, El Feki A, Makni-Ayedi F. Comparative study on hypocholesterolemic and antioxidant activities of various extracts of fenugreek seeds. Food Chem. 2013; 138(2-3): 1448-53[DOI][PubMed]
  • 7. Mohammadi A, Oshaghi EA. Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. J Diabetes Metab Disord. 2014; 13(1): 20[DOI][PubMed]
  • 8. Rahman S, Begum H, Rahman Z, Ara F, Iqbal M, Mohammad YA. Effect of cinnamon (cinnamomum cassia) as a lipid lowering agent on hypercholesterolemic rats. J Enam Med College. 2013; 3(2): 94-8
  • 9. Floyd JS, Brody JA, Tiniakou E, Psaty BM, Mammen A. Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy. Muscle Nerve. 2016; 54(1): 142-4[DOI][PubMed]
  • 10. Tada H, Kobayashi J, Kawashiri MA, Miyashita K, Nohara A, Inazu A, et al. Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy. Lipids Health Dis. 2016; 15: 66[DOI][PubMed]
  • 11. Sahebkar A, Watts GF. New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect? Cardiovasc Drugs Ther. 2013; 27(6): 559-67[DOI][PubMed]
  • 12. Vijayakumar MV, Pandey V, Mishra GC, Bhat MK. Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor. Obesity (Silver Spring). 2010; 18(4): 667-74[DOI][PubMed]
  • 13. Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, et al. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol. 2007; 85(9): 837-47[DOI][PubMed]
  • 14. Ranasinghe P, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med. 2013; 13: 275[DOI][PubMed]
  • 15. Goodarzi MT, Tootoonchi AS, Karimi J, Abbasi OE. Anti-diabetic effects of aqueous extracts of three Iranian medicinal plants in type 2 diabetic rats induced by high fructose diet. Avi J Med Biochem. 2013; 1(1): 7-13
  • 16. Joshi K, Awte S, Bhatnagar P, Walunj S, Gupta R, Joshi S, et al. Cinnamomum zeylanicum extract inhibits proinflammatory cytokine tnf: In vitro and in vivo studies. Res Pharmaceutical Biotechnol. 2010; 2(2): 14-21
  • 17. Vetal S, Bodhankar SL, Mohan V, Thakurdesai PA. Anti-inflammatory and anti-arthritic activity of type-a procyanidine polyphenols from bark of cinnamomum zeylanicum in rats. Food Sci Human Wellness. 2013; 2(2): 59-67
  • 18. Manosi D, Suvra M, Budhimanta M, Jayram H. Ethnobotany, phytochemical and pharmacological aspects of Cinnamomum zeylanicum blume. Inter Res J Pharm. 2013; 4: 58-63
  • 19. Simic A, Sokovic MD, Ristic M, Grujic-Jovanovic S, Vukojevic J, Marin PD. The chemical composition of some Lauraceae essential oils and their antifungal activities. Phytother Res. 2004; 18(9): 713-7[DOI][PubMed]
  • 20. Taher M, Deny S, Mohamad Roji S, Hasnah M, Fadzilah A, Farediah A. Antioxdant activity of cinnamtannin B1 from cinnamomum zeylanicum blume. Phytomedicines. 2006; 16: 601-8
  • 21. Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr. 2011; 51(6): 547-62[DOI][PubMed]
  • 22. Hosseini ZN, Moghadam S, Ebrahimi F, Abdollahi M, Zahedi M, Nazari M. In Vitro screening of selected Iranian medicinal plants against helicobacter pylori. Int J of Green Pharm. 2011; 5: 282-5
  • 23. Amin KA, Abd El-Twab TM. Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: role of atorvastatine and cinnamon. Int J Clin Exp Med. 2009; 2(3): 254-65[PubMed]
  • 24. Pandey S, Pandey R, Singh P. Phytochemical screening of selected medicinal plant cinnamon zeylanicum bark extract, area of research; uttarakhand, India. Inter J Sci Res Public. 2014; 4: 1-6
  • 25. Abbasi O. E. , Noori S. A. , Rezaei A. Effects of walnut on lipid profile as well as the expression of sterol-regulatory element binding protein-1c(SREBP-1c) and peroxisome proliferator activated receptors α(PPARα) in Diabetic Rat. Food Nut Sci. 2012; : 255-9
  • 26. Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters. Cholesterol. 2015; 2015: 958560[DOI][PubMed]
  • 27. Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, et al. Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Hepatology. 2008; 48(1): 109-18[DOI][PubMed]
  • 28. Lai YS, Lee WC, Lin YE, Ho CT, Lu KH, Lin SH, et al. Ginger essential oil ameliorates hepatic injury and lipid accumulation in high fat diet-induced nonalcoholic fatty liver disease. J Agric Food Chem. 2016; 64(10): 2062-71[DOI][PubMed]
  • 29. Badalzadeh R, Shaghaghi M, Mohammadi M, Dehghan G, Mohammadi Z. The effect of Cinnamon extract and long-term aerobic training on heart function, biochemical alterations and lipid profile following exhaustive exercise in male Rats. Adv Pharm Bull. 2014; 4: 515-20
  • 30. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006; 36(5): 340-4[DOI][PubMed]
  • 31. Asadi S, Sohrabi M, Zarei S, Ghyasvand T, Rezaei Farimani A, Goodarzi MT. Effects of Curcuma longa and Cinnamon aqueous extracts on Serum Carbohydrates and Lipids metabolism and oxidative status in high Fructose fed Rats. Int Res J Biological Sci. 2014; 3(3): 78-83
  • 32. Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, et al. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food. 2003; 6(3): 183-91[DOI][PubMed]
  • 33. Prasanna M. Hypolipidemic Effect of Fenugreek: A clinical study. Ind J Pharmacol. 2000; 32: 34-6
  • 34. Mohammadi A, Oshaghi EA, Noori Sorkhani A, Oubari F, Hosseini KR, Rezaei A. Effect of opium on lipid profile and expression of liver X receptor alpha (LXRα) in normolipidemic mouse. Food Nut Sci. 2012; 3: 249-54
  • 35. Abbasi Oshaghi E, Tavilani H, Khodadadi I, Goodarzi MT. Dill tablet: a potential antioxidant and anti-diabetic medicine. Asian Pac J Trop Biomed. 2015; 59: 720-7
  • 36. Eidi A, Eidi M, Sookhteh M. Effect of alcoholic extracts Fenugreek seeds (Trigonella foenum graecum L.) in the activity of hepatic enzymes in normal and diabetic rats. J Med Plant. 2006; 5: 36-41
  • 37. Gandhi K, Sasikumar S, Eagappan K. Coalesced impact of green tea and cinnamon on metabolic parameters of overweight subjects. J Nutr Disord Ther. 2015; 2015
  • 38. Javed I, Faisal I, Rahman Z, Khan MZ, Muhammad F, Aslam B, et al. Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pak J Pharm Sci. 2012; 25(1): 141-7[PubMed]
  • 39. Hassan SA, Barthwal R, Nair MS, Haque SS. Aqueous bark extract of Cinnamomum Zeylanicum: a potential therapeutic agent for streptozotocin-induced type 1 diabetes mellitus (T1DM) rats. Trop J Pharm Res. 2012; 11(3): 429-35
  • 40. Sambaiah K, Srinivasan K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Nahrung. 1991; 35(1): 47-51[PubMed]
  • 41. Abbasi Oshaghi E, Tavilani H, Khodadadi I, Goodarzi MT. Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat. Int J Appl Basic Med Res. 2016; 6: 111-4
  • 42. Kumano-Kuramochi M, Fujimura T, Komba S, Maeda-Yamamoto M, Machida S. Screening, expression, and characterization of an anti-human oxidized low-density lipoprotein single-chain variable fragment. J Biosci Bioeng. 2016; 122(3): 287-93[DOI][PubMed]
  • 43. Venkatesan N, Devaraj SN, Devaraj H. Increased binding of LDL and VLDL to apo B,E receptors of hepatic plasma membrane of rats treated with Fibernat. Eur J Nutr. 2003; 42(5): 262-71[DOI][PubMed]
  • 44. da Cunha V, Martin-McNulty B, Vincelette J, Zhang L, Rutledge JC, Wilson DW, et al. Interaction between mild hypercholesterolemia, HDL-cholesterol levels, and angiotensin II in intimal hyperplasia in mice. J Lipid Res. 2006; 47(3): 476-83[DOI][PubMed]
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