Jundishapur Journal of Natural Pharmaceutical Products

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Histopathological Study of Hydroalcoholic Extract of Terminalia catappa Leaves in Treatment of Indomethacin-Induced Gastric Ulcer in Rats

Ardeshir Arzi 1 , Neda Sistani Karampour 2 , * , Anahita Rezaei 3 and Amin Gholamhoseyni 2
Authors Information
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2017, 12 (3 (Supp)); e38019
  • Published Online: September 4, 2016
  • Article Type: Research Article
  • Received: May 18, 2016
  • Revised: June 16, 2016
  • Accepted: June 22, 2016
  • DOI: 10.5812/jjnpp.38019

To Cite: Arzi A, Sistani Karampour N, Rezaei A, Gholamhoseyni A. Histopathological Study of Hydroalcoholic Extract of Terminalia catappa Leaves in Treatment of Indomethacin-Induced Gastric Ulcer in Rats, Jundishapur J Nat Pharm Prod. 2017 ; 12(3 (Supp)):e38019. doi: 10.5812/jjnpp.38019.

Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Kalant H, Grant D, Mitchel J. Principles of Medical Pharmacology. 7 ed. Canada: Elsevier Canada Ltd; 2007. p. 557-9.
  • 2. Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24(2):121-32. doi: 10.1016/j.bpg.2009.11.005. [PubMed: 20227026].
  • 3. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231(25):232-5. [PubMed: 5284360].
  • 4. Verma VK, Singh N, Saxena P, Singh R. Anti-ulcer and Antioxidant activity of Moringaoleifera (Lam) leaves against Aspirin and ethanol induced gastric ulcer in rats. Int J Pharm. 2012;2(2):46-57.
  • 5. Thomson LAJ, Evans B. Terminalia catappa (tropical almond). Species Profiles Pacific Island Agroforestry. 2006;2:1-20.
  • 6. Joy PP, Thomas J, Mathew S, Skaria BP. Medicinal plants. Trop horticulture. 1998;2:449-632.
  • 7. Graham SA. The genera of Rhizophoraceae and Combretaceae in the southeastern United States. J Arnold Arboretum. 1964;45(3):285-301.
  • 8. Kumar BG, Kumari D, Sravanthi G, Rajeshwar G, Umadevi V, Kotla NG. Antiulcer activity of ethanolic extract of Terminalia catappa leaves against gastric ulcers by pyrolic ligation induced model in rats. Int J Pharm sci Sci Drug Res. 2014;6(1):38-40.
  • 9. Fyhrquist P, Mwasumbi L, Haeggstrom CA, Vuorela H, Hiltunen R, Vuorela P. Ethnobotanical and antimicrobial investigation on some species of Terminalia and Combretum (Combretaceae) growing in Tanzania. J Ethnopharmacol. 2002;79(2):169-77. [PubMed: 11801378].
  • 10. Masuda T, Yonemori S, Oyama Y, Takeda Y, Tanaka T, Andoh T, et al. Evaluation of the antioxidant activity of environmental plants: activity of the leaf extracts from seashore plants. J Agric Food Chem. 1999;47(4):1749-54. [PubMed: 10564049].
  • 11. Yeh CB, Yu YL, Lin CW, Chiou HL, Hsieh MJ, Yang SF. Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma. BMC Complement Altern Med. 2014;14:141. doi: 10.1186/1472-6882-14-141. [PubMed: 24886639].
  • 12. Fan YM, Xu LZ, Gao J, Wang Y, Tang XH, Zhao XN, et al. Phytochemical and antiinflammatory studies on Terminalia catappa. Fitoterapia. 2004;75(3-4):253-60. doi: 10.1016/j.fitote.2003.11.007. [PubMed: 15158981].
  • 13. Chen PS, Li JH, Liu TY, Lin TC. Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin-induced genotoxicity in Chinese hamster ovary cells. Cancer Lett. 2000;152(2):115-22. [PubMed: 10773401].
  • 14. Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, et al. Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. J Nutr Biochem. 2006;17(3):177-82. doi: 10.1016/j.jnutbio.2005.06.008. [PubMed: 16169207].
  • 15. Chen PS, Li JH. Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Toxicol Lett. 2006;163(1):44-53. doi: 10.1016/j.toxlet.2005.09.026. [PubMed: 16242868].
  • 16. Mininel FJ, Leonardo Junior CS, Espanha LG, Resende FA, Varanda EA, Leite CQ, et al. Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity. Evid Based Complement Alternat Med. 2014;2014:676902. doi: 10.1155/2014/676902. [PubMed: 24734110].
  • 17. Ratnasooriya WD, Dharmasiri MG. Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats. Asian J Androl. 2000;2(3):213-9. [PubMed: 11225980].
  • 18. Nagappa AN, Thakurdesai PA, Venkat Rao N, Singh J. Antidiabetic activity of Terminalia catappa Linn fruits. J Ethnopharmacol. 2003;88(1):45-50. [PubMed: 12902049].
  • 19. Arzi A, Ahamehe M, Sarahroodi S. Effect of hydroalcoholic extract of Lavandula officinalis on nicotine-induced convulsion in mice. Pak J Biol Sci. 2011;14(11):634-40. [PubMed: 22235504].
  • 20. Akpamu U, Owoyele VB, Ozor M, Osifo UC. Indomethacin-Induced Gastric Ulcer: Model in Female Wistar Rats. Int J Basic Appl Innovative Res. 2014;2(4):78-84.
  • 21. Yadegari M, Khazaei M, Ghorbani R, Rezae M, Izadi B, Sheikholeslam A. Wound Healing Effect of Falcaria Vulgaris’ Leaves on Aspirin Induced Gastric Ulcer in Rats [in Persian]. J Kermanshah Univ Med Sci. 2006;10(3).
  • 22. Dursun H, Bilici M, Albayrak F, Ozturk C, Saglam MB, Alp HH, et al. Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. BMC Gastroenterol. 2009;9:36. doi: 10.1186/1471-230X-9-36. [PubMed: 19457229].
  • 23. Olaleye SB, Farombi EO. Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. Phytother Res. 2006;20(1):14-20. doi: 10.1002/ptr.1793. [PubMed: 16397915].
  • 24. Boonchum W, Vacharapiyasophon P, Kanjanapothi D, Pekkoh J, Amornlerdpison D, Pumas C, et al. Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand. Chiang Mai J Sci. 2012;39(2):292-9.
  • 25. Mozaffari I, Rashidi M, Taherimoghadam AR. Study of anti-inflammatory and healing effects of Achillea millefolium in the treatment of indomethacin-induced gasthic ulcer in rat [in Persian]. J Qazvin Univ Med Sci. 2005;33:9-13.
  • 26. Levi S, Goodlad RA, Lee CY, Stamp G, Walport MJ, Wright NA, et al. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet. 1990;336(8719):840-3. [PubMed: 1699093].
  • 27. Das D, Bandyopadhyay D, Bhattacharjee M, Banerjee RK. Hydroxyl radical is the major causative factor in stress-induced gastric ulceration. Free Radic Biol Med. 1997;23(1):8-18. [PubMed: 9165292].
  • 28. Pratt DE. Natural Antioxidants from Plant Material. In: Huang MT, Ho CT, Le CY, editors. Phenolic Compounds in Food and Their Effects on Health II. 507. US: J Am Chem Soc; 1992. p. 54-71.
  • 29. Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14(8):581-91. [PubMed: 11113992].
  • 30. Devi RS, Narayan S, Vani G, Shyamala Devi CS. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem Biol Interact. 2007;167(1):71-83. doi: 10.1016/j.cbi.2007.01.011. [PubMed: 17327128].
  • 31. Gupta M, Mazumder UK, Manikandan L, Bhattacharya S, Senthilkumar GP, Suresh R. Anti-ulcer activity of ethanol extract of Terminaliapallida Brandis. in Swiss albino rats. J Ethnopharmacol. 2005;97(2):405-8. doi: 10.1016/j.jep.2004.10.017. [PubMed: 15707782].
  • 32. Jawanjal H, Rajput MS, Agrawal P, Dange V. Pharmacological evaluation of fruits of Terminalia belerica Roxb. for antiulcer activity. J Complement Integr Med. 2012;9:Article 9. doi: 10.1515/1553-3840.1556. [PubMed: 22713279].
  • 33. Pinheiro Silva L, Damacena de Angelis C, Bonamin F, Kushima H, Jose Mininel F, Campaner Dos Santos L, et al. Terminalia catappa L.: a medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. J Ethnopharmacol. 2015;159:285-95. doi: 10.1016/j.jep.2014.11.025. [PubMed: 25460589].
  • 34. Annegowda HV, Nee CW, Mordi MN, Ramanathan S, Mansor SM. Evaluation of Phenolic Content and Antioxidant Property of Hydrolysed Extracts of Terminalia catappa L. Leaf. Asian J Plant Sci. 2010;9(8):479-85. doi: 10.3923/ajps.2010.479.485.
  • 35. Lin CC, Hsu YF, Lin TC. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6. doi: 10.1142/S0192415X99000422. [PubMed: 10592846].
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