Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Comparison of Hibiscus sabdariffa L. Extract and Enalapril with Regard to Their Effect on Lung Fibrosis in a Bleomycin-induced Rat Model of Lung Fibrosis

Ali Asghar Hemmeti 1 , Mohammad Javad Khodayar 2 , Alireza Malayeri 1 , Mohammad Ali Rashidi Nooshabadi 3 , Nastaran Ranjbari 4 and Mohammad Reza Rashidi Nooshabadi 1 , *
Authors Information
1 Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2 Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Genetics, College of Varamin-Pishva Branch, Islamic Azad University, Varamin, IR Iran
4 Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: May 2018, 13 (2); e38798
  • Published Online: August 31, 2016
  • Article Type: Research Article
  • Received: May 12, 2016
  • Revised: July 1, 2016
  • Accepted: August 17, 2016
  • DOI: 10.17795/jjnpp-38798

To Cite: Hemmeti A A, Khodayar M J, Malayeri A, Rashidi Nooshabadi M A, Ranjbari N, et al. Comparison of Hibiscus sabdariffa L. Extract and Enalapril with Regard to Their Effect on Lung Fibrosis in a Bleomycin-induced Rat Model of Lung Fibrosis, Jundishapur J Nat Pharm Prod. 2018 ; 13(2):e38798. doi: 10.17795/jjnpp-38798.

Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Couluris M, Kinder BW, Xu P, Gross-King M, Krischer J, Panos RJ. Treatment of idiopathic pulmonary fibrosis with losartan: a pilot project. Lung. 2012;190(5):523-7. doi: 10.1007/s00408-012-9410-z. [PubMed: 22810758].
  • 2. Borthwick LA, Wynn TA, Fisher AJ. Cytokine mediated tissue fibrosis. Biochim Biophys Acta. 2013;1832(7):1049-60. doi: 10.1016/j.bbadis.2012.09.014. [PubMed: 23046809].
  • 3. De Langhe E, Cailotto F, De Vooght V, Aznar-Lopez C, Vanoirbeek JA, Luyten FP, et al. Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis. Respir Res. 2015;16:38. doi: 10.1186/s12931-015-0202-x. [PubMed: 25849157].
  • 4. B. Moore B , Lawson WE, Oury TD, Sisson TH, Raghavendran K, Hogaboam CM. Animal models of fibrotic lung disease. Am J Respir Cell Mol Biol. 2013;49(2):167-79. doi: 10.1165/rcmb.2013-0094TR. [PubMed: 23526222].
  • 5. Goodman RB, Pugin J, Lee JS, Matthay MA. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003;14(6):523-35. [PubMed: 14563354].
  • 6. Hao Y, Liu Y. Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats. Biol Pharm Bull. 2016;39(4):457-65. doi: 10.1248/bpb.b15-00358. [PubMed: 26822530].
  • 7. Otsuka M, Takahashi H, Shiratori M, Chiba H, Abe S. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004;59(1):31-8. [PubMed: 14694243].
  • 8. Marshall RP, McAnulty RJ, Laurent GJ. Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor. Am J Respir Crit Care Med. 2000;161(6):1999-2004. doi: 10.1164/ajrccm.161.6.9907004. [PubMed: 10852780].
  • 9. Pacurari M, Kafoury R, Tchounwou PB, Ndebele K. The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling. Int J Inflam. 2014;2014:689360. doi: 10.1155/2014/689360. [PubMed: 24804145].
  • 10. Schwaiblmair M, Behr W, Haeckel T, Markl B, Foerg W, Berghaus T. Drug induced interstitial lung disease. Open Respir Med J. 2012;6:63-74. doi: 10.2174/1874306401206010063. [PubMed: 22896776].
  • 11. Kar S, Konsam S, Hore G, Mitra S, Biswas S, Sinha A, et al. Therapeutic use of fisetin, curcumin, and mesoporous carbaon nanoparticle loaded fisetin in bleomycin-induced idiopathic pulmonary fibrosis. Biomed Res Ther. 2015;2(4):250-62.
  • 12. Nishioka Y, Azuma M, Kishi M, Aono Y. Targeting platelet-derived growth factor as a therapeutic approach in pulmonary fibrosis. J Med Invest. 2013;60(3-4):175-83. [PubMed: 24190033].
  • 13. Chaudhary NI, Schnapp A, Park JE. Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med. 2006;173(7):769-76. doi: 10.1164/rccm.200505-717OC. [PubMed: 16415276].
  • 14. Li X, Rayford H, Uhal BD. Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice. Am J Pathol. 2003;163(6):2523-30. doi: 10.1016/S0002-9440(10)63607-3. [PubMed: 14633624].
  • 15. Grande NR, Peao MND, de Sa CM, Aguas AP. Lung fibrosis induced by bleomycin: structural changes and overview of recent advances. Scanning Microscopy. 1998;12(3):487-94.
  • 16. Ebrahimi Naghani E, Javadi I, Rashidinooshabadi M, Godarzi M, Houshmand G. Protective effects of hydroalcoholic extract of hypericum perforatum against bleomycin-induced pulmonary fibrosis in rats. J Babol Un Med Sci. 2016;18(1):44-51.
  • 17. anaka K, Azuma A, Mizushima T, Kurotsu S. Protective and therapeutic effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis and lung function in mice. Am J Respir Crit Care Med. 2015. eA3471.
  • 18. Teixeira KC, Soares FS, Rocha LG, Silveira PC, Silva LA, Valenca SS, et al. Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine. Pulm Pharmacol Ther. 2008;21(2):309-16. doi: 10.1016/j.pupt.2007.07.006. [PubMed: 17904883].
  • 19. Adeyemi DO, Ukwenya VO, Obuotor EM, Adewole SO. Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage. BMC Complement Altern Med. 2014;14:277. doi: 10.1186/1472-6882-14-277. [PubMed: 25077880].
  • 20. Maganha EG, Halmenschlager RC, Rosa RM, Henriques JAP, Ramos ALLP, Saffi J. Pharmacological evidences for the extracts and secondary metabolites from plants of the genus Hibiscus. Food Chem. 2010;118(1):1-10. doi: 10.1016/j.foodchem.2009.04.005.
  • 21. Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. - a phytochemical and pharmacological review. Food Chem. 2014;165:424-43. doi: 10.1016/j.foodchem.2014.05.002. [PubMed: 25038696].
  • 22. Hopkins AL, Lamm MG, Funk JL, Ritenbaugh C. Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia. 2013;85:84-94. doi: 10.1016/j.fitote.2013.01.003. [PubMed: 23333908].
  • 23. Rahmani AH, Goudarzi M, Rashidi Nooshabadi MR, Houshmand GH, Khadem Haghighian H. Protective effect of red lentil (lens culinaris) extract against carbon tetrachloride-induced hepatotoxicity in mice. J Babol Un Med Sci. 2014;16(2):49-55.
  • 24. Houshmand G, Tarahomi S, Arzi A, Goudarzi M, Bahadoram M, Rashidi-Nooshabadi M. Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats. J Clin Diagn Res. 2016;10(6):FF05-8. doi: 10.7860/JCDR/2016/17813.7977. [PubMed: 27504309].
  • 25. Salimi A, Motaharitabar E, Goudarzi M, Rezaie A, Kalantari H. Toxicity evaluation of microemulsion (nano size) of sour cherry kernel extract for the oral bioavailability enhancement. Jundishapur J Nat Pharm Prod. 2014;9(1):16-23. [PubMed: 24644434].
  • 26. Kalantari H, Jalali M, Jalali A, Mahdavinia M, Salimi A, Juhasz B, et al. Protective effect of Cassia fistula fruit extract against bromobenzene-induced liver injury in mice. Humam exp toxicol. 2010:9.6032711038626E+14.
  • 27. Kalantari H, Khorsandi LS, Taherimobarakeh M. The protective effect of the Curcuma longa extract on Acetaminophen–induced hepatotoxicity in mice. Jundishapur J Nat pharm prod. 2007;2007(01, Winter):7-12.
  • 28. Javadi I, Rashidi Nooshabadi MR, Goudarzi M, Roudbari R. Protective effects of celery (Apium graveloens) seed extract on bleomycin-induced pulmonary fibrosis in rats. J Babol Un Med Sci. 2015;17(1):70-6.
  • 29. Yahaya T, Okpuzor J, Ajayi T. Antioxidant activity of roselle (hibiscus sabdariffa), moringa (moringa oleifera), ginger (zingiber officinale) and'ugwu'(telfairia occidentalis) in the lungs of albino rats (rattus norvegicus) exposed to cement dust. Annual Res Rev Biol. 2014;4(5):736.
  • 30. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54. [PubMed: 942051].
  • 31. Khodayar MJ, Kiani M, Hemmati AA, Rezaie A, Zerafatfard MR, Rashidi Nooshabadi MR, et al. The preventive effect of atorvastatin on paraquat-induced pulmonary fibrosis in the rats. Adv Pharm Bull. 2014;4(4):345-9. doi: 10.5681/apb.2014.050. [PubMed: 25436189].
  • 32. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302-10. [PubMed: 672633].
  • 33. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem. 1996;29(3):225-9. [PubMed: 8740508].
  • 34. Javad-Mousavi SA, Hemmati AA, Mehrzadi S, Hosseinzadeh A, Houshmand G, Rashidi Nooshabadi MR, et al. Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats. Biomed Pharmacother. 2016;81:329-36. doi: 10.1016/j.biopha.2016.04.027. [PubMed: 27261610].
  • 35. Park S, Lee EJ. Recent advances in idiopathic pulmonary fibrosis. Tuberc Respir Dis (Seoul). 2013;74(1):1-6. doi: 10.4046/trd.2013.74.1.1. [PubMed: 23390446].
  • 36. Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, et al. Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004;286(1):L156-64. doi: 10.1152/ajplung.00313.2002. [PubMed: 12754187].
  • 37. Wei M, Chu X, Jiang L, Yang X, Cai Q, Zheng C, et al. Protocatechuic acid attenuates lipolysaccharide-induced acute lung injury. Inflammation. 2012;35(3):1169-78. doi: 10.1007/s10753-011-9425-2. [PubMed: 22466397].
  • 38. Sen S, Chakraborty R, Sridhar C, Reddy YSR, De B. Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. Int J Pharm Sci Rev Res. 2010;3(1):91-100.
  • 39. Masella R, Santangelo C, D'Archivio M, Li Volti G, Giovannini C, Galvano F. Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms. Curr Med Chem. 2012;19(18):2901-17. [PubMed: 22519395].
  • 40. Farombi EO, Fakoya A. Free radical scavenging and antigenotoxic activities of natural phenolic compounds in dried flowers of Hibiscus sabdariffa L. Mol Nutr Food Res. 2005;49(12):1120-8. doi: 10.1002/mnfr.200500084. [PubMed: 16254885].
  • 41. Sayago-Ayerdi SG, Goni I. [Hibiscus sabdariffa L: source of antioxidant dietary fiber]. Arch Latinoam Nutr. 2010;60(1):79-84. [PubMed: 21090279].
  • 42. Tulek B, Kiyan E, Toy H, Kiyici A, Narin C, Suerdem M. Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycin-induced pulmonary fibrosis in rats. Clin Invest Medicine. 2011;34(6):341-8.
  • 43. Zhao X, Zhai S, An MS, Wang YH, Yang YF, Ge HQ, et al. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PLoS One. 2013;8(10):78220. doi: 10.1371/journal.pone.0078220. [PubMed: 24205164].
  • 44. Li C, Jiang W, Zhu H, Hou J. Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis. Pharm Biol. 2012;50(4):413-9. doi: 10.3109/13880209.2011.608193. [PubMed: 22129045].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments