Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats

Esmaeel Ebrahimi 1 , Alireza Kheirollah 2 , Esrafil Mansouri 3 , Hossein Babaahmadi-Rezaei 4 and Ghorban Mohammadzadeh 4 , *
Authors Information
1 Health Research Institute, Department of Clinical Biochemistry, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Clinical Biochemistry, Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Clinical Biochemistry, Hyperlipidemia Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: 14 (3); e55456
  • Published Online: May 19, 2019
  • Article Type: Research Article
  • Received: June 18, 2017
  • Revised: February 10, 2018
  • Accepted: April 21, 2018
  • DOI: 10.5812/jjnpp.55456

To Cite: Ebrahimi E, Kheirollah A, Mansouri E , Babaahmadi-Rezaei H, Mohammadzadeh G. Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats, Jundishapur J Nat Pharm Prod. Online ahead of Print ; 14(3):e55456. doi: 10.5812/jjnpp.55456.

Copyright © 2019, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Georgescu A. Vascular dysfunction in diabetes: The endothelial progenitor cells as new therapeutic strategy. World J Diabetes. 2011;2(6):92-7. doi: 10.4239/wjd.v2.i6.92. [PubMed: 21860692]. [PubMed Central: PMC3158877].
  • 2. Krentz AJ, Bailey CJ. Oral antidiabetic agents: Current role in type 2 diabetes mellitus. Drugs. 2005;65(3):385-411. doi: 10.2165/00003495-200565030-00005. [PubMed: 15669880].
  • 3. Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, et al. Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2006;29(8):1963-72. doi: 10.2337/dc06-9912. [PubMed: 16873813].
  • 4. Tiwari AK, Rao JM. Diabetes mellitus and multiple therapeutic approaches of phyochemicals: Present status and future prospects. Curr Sci. 2002;83:30-8.
  • 5. Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 2012;3(4):200-1. doi: 10.4103/2231-4040.104709. [PubMed: 23378939]. [PubMed Central: PMC3560124].
  • 6. Arora D, Rani A, Sharma A. A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacogn Rev. 2013;7(14):179-87. doi: 10.4103/0973-7847.120520. [PubMed: 24347926]. [PubMed Central: PMC3841996].
  • 7. Preethi KC, Kuttan G, Kuttan R. Antioxidant potential of an extract of calendula officinalis. Flowersin vitro. Andin vivo. Pharm Biol. 2008;44(9):691-7. doi: 10.1080/13880200601009149.
  • 8. John R, Jan N. Calendula officinalis-an important medicinal plant with potential biological properties. Proceed India National Sci Acad. 2017;93(0). doi: 10.16943/ptinsa/2017/49126.
  • 9. Di Lorenzo C, Dell'Agli M, Badea M, Dima L, Colombo E, Sangiovanni E, et al. Plant food supplements with anti-inflammatory properties: A systematic review (II). Crit Rev Food Sci Nutr. 2013;53(5):507-16. doi: 10.1080/10408398.2012.691916. [PubMed: 23391017].
  • 10. Chakraborthy GS, Arora R, Majee C. Antidiabetic and antihyperlipidaemic effect of hydro-alcoholic extract of calendula officinalis. Int Res J Pharm. 2011;2:61-5.
  • 11. Moradkhani S, Salehi I, Abdolmaleki S, Komaki A. Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats. Anc Sci Life. 2015;34(3):156-61. doi: 10.4103/0257-7941.157160. [PubMed: 26120230]. [PubMed Central: PMC4458906].
  • 12. Mathur R, Mamta G. Antimicrobial and phytochemical estimation of Calendula officinalis against human pathogenic microorganism. Int J Innov Bio Sci. 2011;1:1-10.
  • 13. Ukiya M, Akihisa T, Yasukawa K, Tokuda H, Suzuki T, Kimura Y. Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers. J Nat Prod. 2006;69(12):1692-6. doi: 10.1021/np068016b. [PubMed: 17190444].
  • 14. Ebrahimi E, Shirali S, Talaei R. The protective effect of marigold hydroalcoholic extract in STZ-induced diabetic rats: Evaluation of cardiac and pancreatic biomarkers in the serum. J Botany. 2016;2016:1-6. doi: 10.1155/2016/9803928.
  • 15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9. doi: 10.1007/BF00280883. [PubMed: 3899825].
  • 16. Ebrahimi E, Mohammadzadeh G, Mansouri E, Aberomand M. Effects of hydro-alcoholic leaf extract of citrullus colocynthis on biochemical factors and histopathological changes in streptozotocin-induced diabetic rats. Jundishapur J Nat Pharm Prod. 2016;11(3). doi: 10.17795/jjnpp-33214.
  • 17. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 1967;16(1):35-9. doi: 10.2337/diab.16.1.35. [PubMed: 5333500].
  • 18. Ebrahimie M, Esmaeili F, Cheraghi S, Houshmand F, Shabani L, Ebrahimie E. Efficient and simple production of insulin-producing cells from embryonal carcinoma stem cells using mouse neonate pancreas extract, as a natural inducer. PLoS One. 2014;9(3). e90885. doi: 10.1371/journal.pone.0090885. [PubMed: 24614166]. [PubMed Central: PMC3948699].
  • 19. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008;51(2):216-26. doi: 10.1007/s00125-007-0886-7. [PubMed: 18087688].
  • 20. Rajkumar L, Srinivasan N, Balasubramanian K, Govindarajulu P. Increased degradation of dermal collagen in diabetic rats. Indian J Exp Biol. 1991;29(11):1081-3. [PubMed: 1816088].
  • 21. Ramesh B, Pugalendi KV. Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats. Yale J Biol Med. 2005;78(4):189-96. [PubMed: 16720013]. [PubMed Central: PMC2259150].
  • 22. Erenmemisoglu A, Saraymen R, Ustun S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie. 1997;52(8):645-6. [PubMed: 9292920].
  • 23. Botros M, Sikaris KA. The de ritis ratio: The test of time. Clin Biochem Rev. 2013;34(3):117-30. [PubMed: 24353357]. [PubMed Central: PMC3866949].
  • 24. Rajesh MG, Latha MS. Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J Ethnopharmacol. 2004;91(1):99-104. doi: 10.1016/j.jep.2003.12.011. [PubMed: 15036476].
  • 25. Rana SV, Singh R, Verma S. Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury. Indian J Exp Biol. 1996;34(2):177-9. [PubMed: 8641719].
  • 26. Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ. Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002;51(8):2496-504. doi: 10.2337/diabetes.51.8.2496. [PubMed: 12145163].
  • 27. Hamada Y, Fukagawa M. A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy. Kobe J Med Sci. 2007;53(1-2):53-61. [PubMed: 17582205].
  • 28. Teoh SL, Abd Latiff A, Das S. Histological changes in the kidneys of experimental diabetic rats fed with Momordica charantia (bitter gourd) extract. Rom J Morphol Embryol. 2010;51(1):91-5. [PubMed: 20191126].
  • 29. Mythili MD, Vyas R, Akila G, Gunasekaran S. Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microsc Res Tech. 2004;63(5):274-81. doi: 10.1002/jemt.20039. [PubMed: 15170757].
  • 30. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001;50(6):537-46. [PubMed: 11829314].
  • 31. Jin HY, Liu WJ, Park JH, Baek HS, Park TS. Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. Arch Med Res. 2009;40(7):536-44. doi: 10.1016/j.arcmed.2009.09.005. [PubMed: 20082866].
  • 32. Oh YS. Plant-derived compounds targeting pancreatic beta cells for the treatment of diabetes. Evid Based Complement Alternat Med. 2015;2015:1-12. doi: 10.1155/2015/629863.
  • 33. Balasubashini MS, Rukkumani R, Viswanathan P, Menon VP. Ferulic acid alleviates lipid peroxidation in diabetic rats. Phytother Res. 2004;18(4):310-4. doi: 10.1002/ptr.1440. [PubMed: 15162367].
  • 34. Mahesh T, Menon VP. Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Phytother Res. 2004;18(2):123-7. doi: 10.1002/ptr.1374. [PubMed: 15022163].
  • 35. Youl E, Bardy G, Magous R, Cros G, Sejalon F, Virsolvy A, et al. Quercetin potentiates insulin secretion and protects INS-1 pancreatic beta-cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol. 2010;161(4):799-814. doi: 10.1111/j.1476-5381.2010.00910.x. [PubMed: 20860660]. [PubMed Central: PMC2992896].
  • 36. Wortham M, Sander M. Mechanisms of beta-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016;18 Suppl 1:78-86. doi: 10.1111/dom.12729. [PubMed: 27615135]. [PubMed Central: PMC5021190].

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