Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Crocin-Induced Endothelium-Dependent Relaxation in Isolated Rat Aorta

Bibi Marjan Razavi 1 , Meysam Seydali Seyfabad 1 , Hossein Hosseinzadeh 2 and Mohsen Imenshahidi 2 , *
Authors Information
1 Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Pharmacodynamy and Toxicology, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: May 2017, 12 (2); e32801
  • Published Online: September 24, 2016
  • Article Type: Research Article
  • Received: November 22, 2015
  • Revised: May 29, 2016
  • Accepted: September 14, 2016
  • DOI: 10.5812/jjnpp.32801

To Cite: Razavi B M, Seydali Seyfabad M, Hosseinzadeh H, Imenshahidi M. Crocin-Induced Endothelium-Dependent Relaxation in Isolated Rat Aorta, Jundishapur J Nat Pharm Prod. 2017 ; 12(2):e32801. doi: 10.5812/jjnpp.32801.

Abstract
Copyright © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Hosseinzadeh H. Saffron: a herbal medicine of third millennium. Jundishapur J Nat Pharm Prod. 2014; 9(1): 1-2[PubMed]
  • 2. Soeda S, Ochiai T, Shimeno H, Saito H, Abe K, Tanaka H. Pharmacological activities of crocin in saffron. J Nat Med. 2007; 61: 102-11[DOI]
  • 3. Hosseinzadeh H, Nassiri-Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res. 2013; 27(4): 475-83[DOI][PubMed]
  • 4. Ziaee T, Razavi BM, Hosseinzadeh H. Saffron reduced toxic effects of its constituent, safranal, in acute and subacute toxicities in rats. Jundishapur J Nat Pharm Prod. 2014; 9(1): 3-8[PubMed]
  • 5. Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014; 64: 65-80[DOI][PubMed]
  • 6. Hosseinzadeh H, Khosravan V. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch Iran Med. 2002; : 44-7
  • 7. Hosseinzadeh H, Talebzadeh F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia. 2005; 76(7-8): 722-4[DOI][PubMed]
  • 8. Hosseinzadeh H, Karimi G, Niapoor M. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in Mice. J Med Plants. 2004; 3: 48-58[DOI]
  • 9. Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H. Antidepressant effect of Crocus sativus aqueous extract and its effect on CREB, BDNF, and VGF transcript and protein levels in rat hippocampus. Drug Res (Stuttg). 2015; 65(7): 337-43[DOI][PubMed]
  • 10. Vahdati Hassani F, Naseri V, Razavi B, Mehri S, Abnous K, Hosseinzadeh H. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru. 2014; 8: 22[DOI]
  • 11. Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002; 2: 7[PubMed]
  • 12. Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 2012; 83(5): 888-95[DOI][PubMed]
  • 13. Hosseinzadeh H, Shamsaie F, Mehri S. Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents crocin and safranal. Pharmacogn Mag. 2010; 5: 419-24
  • 14. Abdullaev FI. Biological effects of saffron. Biofactors. 1993; 4(2): 83-6[PubMed]
  • 15. Hosseinzadeh H, Behravan J, Ramezani M, Ajgan K. Anti-tumor and cytotoxic evaluation of Crocus sativus L. stigma and petal extracts using brine shrimp and potato disc assays. J Med Plants. 2005; 4: 59-65
  • 16. Hosseinzadeh H, Sadeghnia H, Abbasi Ghaeni F, Motamedshariaty V, Mohajeri S. Effects of Saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res. 2012; 10: 1002
  • 17. Hosseinzadeh H, Ziaei T. Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task. J Med Plants. 2006; 5(19): 40-50
  • 18. Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 2010; 24(7): 990-4[DOI][PubMed]
  • 19. Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H. The effect of chronic administration of safranal on systolic blood pressure in rats. Iran J Pharm Res. 2015; 14(2): 585-90[PubMed]
  • 20. Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H. The effect of chronic administration of saffron (Crocus sativus) stigma aqueous extract on systolic blood pressure in rats. Jundishapur J Nat Pharm Prod. 2013; 8(4): 175-9[PubMed]
  • 21. Razavi BM, Hosseinzadeh H. Saffron as an antidote or a protective agent against natural or chemical toxicities. Daru. 2015; 23: 31[DOI][PubMed]
  • 22. Veeramani C, Al-Numair KS, Chandramohan G, Alsaif MA, Alhamdan AA, Pugalendi KV. Antihypertensive effect of Melothria maderaspatana leaf fractions on DOCA-salt-induced hypertensive rats and identification of compounds by GC-MS analysis. J Nat Med. 2012; 66(2): 302-10[DOI][PubMed]
  • 23. Krum H, Pellizzer AM. New and emerging drug treatments for hypertension. Aust Fam Physician. 1998; 27(4): 235-7[PubMed]
  • 24. Talha J, Priyanka MAA. Hypertension and herbal plants. Int Res J Pharm. 2011; 2: 26-30
  • 25. Boskabady MH, Shafei MN, Shakiba A, Sefidi HS. Effect of aqueous-ethanol extract from Crocus sativus (saffron) on guinea-pig isolated heart. Phytother Res. 2008; 22(3): 330-4[DOI][PubMed]
  • 26. Fatehi M, Rashidabady T, Hassanabad ZF. Effects of petals extracts of saffron on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas veferens and guinea-pig ileum. J Ethnopharmacol. 2003; 84: 199-203[DOI]
  • 27. Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H. Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iran J Basic Med Sci. 2014; 17(1): 9-13[PubMed]
  • 28. Hadizadeh F, Mohajeri SA, Seifi M. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Pak J Biol Sci. 2010; 13(14): 691-8[PubMed]
  • 29. Parsaee H, Imenshahidi M, Fatehi Z. Lovastatin incubation improves acetylcholine-induced relaxation in isolated aortic rings of diabetic rat. Iran J Pharmaceut Res. 2006; 3: 191-8
  • 30. Mombouli JV, Vanhoutte PM. Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol. 1999; 31(1): 61-74[DOI][PubMed]
  • 31. Dehpour AR, Ghafourifar P, Samenian J, Sadeghipour HR, Sadr SS. The effect of lithium on endothelial-dependent relaxation in rat isolated aorta. Gen Pharmacol. 1995; 26: 1003-7[DOI]
  • 32. Sausbier M, Schubert R, Voigt V, Hirneiss C, Pfeifer A, Korth M, et al. Mechanisms of NO/cGMP-dependent vasorelaxation. Circ Res. 2000; 87(9): 825-30[PubMed]
  • 33. Mashhoodi T, Zahedi-Asl S, Sarkaki A. Inhibitory effect of aluminium on Kcl and phenylephrine induced contraction in isolated rat aorta. Acta Medica Iranica. 2004; 42
  • 34. Tang FT, Qian ZY, Liu PQ, Zheng SG, He SY, Bao LP, et al. Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity. Biochem Pharmacol. 2006; 72(5): 558-65[DOI][PubMed]
  • 35. Razavi BM, Hosseinzadeh H, Abnous K, Imenshahidi M. Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo. Drug Chem Toxicol. 2014; 37(4): 378-83[DOI][PubMed]
  • 36. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013; 16(1): 64-72[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments