Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

The Protective Effect of Cichorium intybus L. Hydroalcoholic Extract Against Methotrexate-Induced Oxidative Stress in Rats

Marzieh Asadi 1 , Mohammad Mohammadi 1 , * , Babak Mohammadian 2 , Ali Shahriari 3 and Hossein Foruozandeh 4
Authors Information
1 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 Department of Biochemistry, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4 Gerash Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: November 30, 2018, 13 (4); e59556
  • Published Online: December 1, 2018
  • Article Type: Research Article
  • Received: August 6, 2017
  • Revised: August 20, 2018
  • Accepted: August 26, 2018
  • DOI: 10.5812/jjnpp.59556

To Cite: Asadi M, Mohammadi M, Mohammadian B , Shahriari A, Foruozandeh H. The Protective Effect of Cichorium intybus L. Hydroalcoholic Extract Against Methotrexate-Induced Oxidative Stress in Rats, Jundishapur J Nat Pharm Prod. 2018 ; 13(4):e59556. doi: 10.5812/jjnpp.59556.

Copyright © 2018, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Kalantari H, Foruozandeh H, Khodayar MJ, Siahpoosh A, Saki N, Kheradmand P. Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide-induced acute liver damage in mice. J Tradit Complement Med. 2018;8(1):120-7. doi: 10.1016/j.jtcme.2017.04.010. [PubMed: 29321999]. [PubMed Central: PMC5755993].
  • 2. Goudarzi M, Kalantar M, Kalantar H. The hepatoprotective effect of gallic acid on mercuric chloride-induced liver damage in rats. Jundishapur J Nat Pharm Prod. 2017;12(4). doi: 10.5812/jjnpp.12345.
  • 3. Kalantari H, Houshmand G, Hasanvand A, Kalantar M, Goudarzi M, Khadem Haghighian H. Ameliorative effects of red lentil extract on sodium arsenite-induced oxidative stress in rats. Jundishapur J Nat Pharm Prod. 2017;(In Pre). doi: 10.5812/jjnpp.64309.
  • 4. Mehrzadi S, Fatemi I, Malayeri AR, Khodadadi A, Mohammadi F, Mansouri E, et al. Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats. Pharmacol Rep. 2018;70(4):712-9. doi: 10.1016/j.pharep.2018.02.007. [PubMed: 29935397].
  • 5. Moosavi M, Rezaei M, Kalantari H, Behfar A, Varnaseri G. l-carnitine protects rat hepatocytes from oxidative stress induced by T-2 toxin. Drug Chem Toxicol. 2016;39(4):445-50. doi: 10.3109/01480545.2016.1141423. [PubMed: 26888052].
  • 6. Bleibel W, Kim S, D'Silva K, Lemmer ER. Drug-induced liver injury: Review article. Dig Dis Sci. 2007;52(10):2463-71. doi: 10.1007/s10620-006-9472-y. [PubMed: 17805971].
  • 7. Brown PM, Pratt AG, Isaacs JD. Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers. Nat Rev Rheumatol. 2016;12(12):731-42. doi: 10.1038/nrrheum.2016.175. [PubMed: 27784891].
  • 8. Mehrzadi S, Mehrabani M, Malayeri AR, Bakhshayesh M, Kalantari H, Goudarzi M. Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats. Acta Chir Belg. 2018:1-9. doi: 10.1080/00015458.2018.1455419. [PubMed: 29587597].
  • 9. Chan EL, Cronstein BN. Mechanisms of action of methotrexate. Bull Hosp Jt Dis. 2013;71(suppl 1):S5-8.
  • 10. Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci. 2016;8:33-42. doi: 10.1016/j.cofs.2016.02.002.
  • 11. Satmbekova D, Srivedavyasasri R, Orazbekov Y, Omarova R, Datkhayev U, Ross SA. Chemical and biological studies on Cichorium intybus L. Nat Prod Res. 2018;32(11):1343-7. doi: 10.1080/14786419.2017.1343319. [PubMed: 28629227]. [PubMed Central: PMC5736470].
  • 12. El-Lakany AM, Aboul-Ela MA, Abdul-Ghani MM, Mekky H. Chemical constituents and biological activities of Cichorium intybus L. Natural Prod Sci. 2004;10(2):69-73.
  • 13. Javadi I, Rashidi Nooshabadi M, Goudarzi M, Roudbari R. Protective effects of celery (Apium graveloens) seed extract on bleomycin-induced pulmonary fibrosis in rats. J Babol Univ Med Sci. 2015;17(1):70-6. doi: 10.22088/jbums.17.1.70.
  • 14. Kalantar M, Houshmand G, Kalantar H, Asadi M, Goudarzi M. Protective effect of hydroalcoholic extract of Lavandula officinalis L. on gentamicin induced nephrotoxicity in rats. J Babol Univ Med Sci. 2016;18(7):62-7. doi: 10.22088/jbums.18.7.62.
  • 15. Kalantar M, Goudarzi M, Khodayar MJ, Babaei J, Foruozandeh H, Bakhtiari N, et al. Protective effects of the hydroalcoholic extract of Capparis spinosa L. against cyclophosphamide-induced nephrotoxicity in mice. Jundishapur J Nat Pharm Prod. 2016;11(4). doi: 10.17795/jjnpp-37240.
  • 16. Goudarzi M, Esmaeilizadeh M, Dolatshahi M, Kalantar H, Frouzandeh H, Kalantar M. Protective effect of elaeagnus angustifolia L. Fruit hydroalcoholic extract on cyclophosphamide-induced nephrotoxicity in mice. Shiraz E Med J. 2018;19(1).
  • 17. Salimi A, Motaharitabar E, Goudarzi M, Rezaie A, Kalantari H. Toxicity evaluation of microemulsion (nano size) of sour cherry kernel extract for the oral bioavailability enhancement. Jundishapur J Nat Pharm Prod. 2014;9(1):16-23. [PubMed: 24644434]. [PubMed Central: PMC3957138].
  • 18. Heibatollah S, Reza NM, Izadpanah G, Sohailla S. Hepatoprotective effect of Cichorium intybus on CCl4-induced liver damage in rats. African j Biochem res. 2008;2(6):141-4.
  • 19. Jamshidzadeh A, Khoshnood MJ, Dehghani Z, Niknahad H. Hepatoprotective activity of Cichorium intybus L. leaves extract against carbon tetrachloride induced toxicity. Iranian J Pharm Res. 2006;5(1):41-6.
  • 20. Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, Goudarzi M. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomed Pharmacother. 2018;97:233-9. doi: 10.1016/j.biopha.2017.10.113. [PubMed: 29091871].
  • 21. Safaei F, Mehrzadi S, Khadem Haghighian H, Hosseinzadeh A, Nesari A, Dolatshahi M, et al. Protective effects of gallic acid against methotrexate-induced toxicity in rats. Acta Chir Belg. 2018;118(3):152-60. doi: 10.1080/00015458.2017.1394672. [PubMed: 29069994].
  • 22. Bahrami N, Mehrzadi S, Goudarzi M, Mansouri E, Fatemi I. Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice. Life Sci. 2018;207:265-71. doi: 10.1016/j.lfs.2018.06.009. [PubMed: 29886059].
  • 23. Mehrzadi S, Bahrami N, Mehrabani M, Motevalian M, Mansouri E, Goudarzi M. Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. Biomed Pharmacother. 2018;103:1464-72. doi: 10.1016/j.biopha.2018.04.194.
  • 24. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70-7. doi: 10.1016/0003-9861(59)90090-6.
  • 25. Kalantar H, Sabetkasaei M, Shahriari A, Haj Molla Hoseini M, Mansouri S, Kalantar M, et al. The effect of rapamycin on oxidative stress in MCF-7 and MDA MB-231 human breast cancer cell lines. Jundishapur J Nat Pharm Prod. 2016;11(3). doi: 10.17795/jjnpp-38177.
  • 26. Kalantar M, Shirali S, Hasanvand A, Valizadeh M, Tavakoli R, Asadi M, et al. Ameliorative effects of hydroalcoholic extract of lavandula officinalis L. on methotrexate-induced oxidative stress in rats. Pharm Sci. 2017;23(1):18-26. doi: 10.15171/PS.2017.04.
  • 27. Fotoohi AK, Albertioni F. Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk Lymphoma. 2008;49(3):410-26. doi: 10.1080/10428190701824569. [PubMed: 18297517].
  • 28. Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005;15(4):316-28. doi: 10.1016/j.numecd.2005.05.003. [PubMed: 16054557].
  • 29. Kim WR, Flamm SL, Di Bisceglie AM, Bodenheimer HC. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatol. 2008;47(4):1363-70. doi: 10.1002/hep.22109. [PubMed: 18366115].
  • 30. Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, et al. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol. 2014;20(29):10158-65. doi: 10.3748/wjg.v20.i29.10158. [PubMed: 25110444]. [PubMed Central: PMC4123346].
  • 31. Vardi N, Parlakpinar H, Cetin A, Erdogan A, Cetin Ozturk I. Protective effect of beta-carotene on methotrexate-induced oxidative liver damage. Toxicol Pathol. 2010;38(4):592-7. doi: 10.1177/0192623310367806. [PubMed: 20448084].
  • 32. Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, et al. Role of grape seed extract on methotrexate induced oxidative stress in rat liver. Am J Chin Med. 2008;36(5):861-72. doi: 10.1142/S0192415X08006302. [PubMed: 19051353].
  • 33. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270-8. doi: 10.4161/oxim.2.5.9498. [PubMed: 20716914]. [PubMed Central: PMC2835915].
  • 34. Street RA, Sidana J, Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evid Based Complement Alternat Med. 2013;2013:579319. doi: 10.1155/2013/579319. [PubMed: 24379887]. [PubMed Central: PMC3860133].
  • 35. Li GY, Gao HY, Huang J, Lu J, Gu JK, Wang JH. Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats. World J Gastroenterol. 2014;20(16):4753-60. doi: 10.3748/wjg.v20.i16.4753. [PubMed: 24782629]. [PubMed Central: PMC4000513].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments