Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Zataria multiflora Alleviates Cisplatin-Induced Oxidative Stress, Apoptosis, and Nephrotoxicity in Mice

Shokooh Karimi 1 , 2 , Fereshteh Talebpour Amiri 1 , * , Ali Reza Khalatbary 1 , Hamid Reza Mohammadi 3 , 4 and Seyed Jalal Hosseinimehr 5
Authors Information
1 Department of Anatomy, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2 Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4 Pharmacutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
5 Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: 14 (3); e63293
  • Published Online: May 7, 2019
  • Article Type: Research Article
  • Received: October 26, 2017
  • Revised: April 16, 2018
  • Accepted: May 13, 2018
  • DOI: 10.5812/jjnpp.63293

To Cite: Karimi S, Talebpour Amiri F, Khalatbary A R, Mohammadi H R, Hosseinimehr S J. Zataria multiflora Alleviates Cisplatin-Induced Oxidative Stress, Apoptosis, and Nephrotoxicity in Mice, Jundishapur J Nat Pharm Prod. Online ahead of Print ; 14(3):e63293. doi: 10.5812/jjnpp.63293.

Copyright © 2019, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Faig J, Haughton M, Taylor RC, D'Agostino RB Jr, Whelen MJ, Porosnicu Rodriguez KA, et al. Retrospective analysis of cisplatin nephrotoxicity in patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy. Am J Clin Oncol. 2018;41(5):432-40. doi: 10.1097/COC.0000000000000301. [PubMed: 27281266]. [PubMed Central: PMC5145782].
  • 2. Naqshbandi A, Rizwan S, Khan F. Dietary supplementation of flaxseed oil ameliorates the effect of cisplatin on rat kidney. J Funct Food. 2013;5(1):316-26. doi: 10.1016/j.jff.2012.11.002.
  • 3. An Y, Xin H, Yan W, Zhou X. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice. Exp Toxicol Pathol. 2011;63(3):215-9. doi: 10.1016/j.etp.2009.12.002. [PubMed: 20060696].
  • 4. dos Santos NA, Carvalho Rodrigues MA, Martins NM, dos Santos AC. Cisplatin-induced nephrotoxicity and targets of nephroprotection: An update. Arch Toxicol. 2012;86(8):1233-50. doi: 10.1007/s00204-012-0821-7. [PubMed: 22382776].
  • 5. Santos NA, Bezerra CS, Martins NM, Curti C, Bianchi ML, Santos AC. Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer Chemother Pharmacol. 2008;61(1):145-55. doi: 10.1007/s00280-007-0459-y. [PubMed: 17396264].
  • 6. Li X, Hassoun HT, Santora R, Rabb H. Organ crosstalk: The role of the kidney. Curr Opin Crit Care. 2009;15(6):481-7. doi: 10.1097/MCC.0b013e328332f69e. [PubMed: 19851101].
  • 7. Naqshbandi A, Khan MW, Rizwan S, Rehman SU, Khan F. Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats. Food Chem Toxicol. 2012;50(2):265-73. doi: 10.1016/j.fct.2011.10.039. [PubMed: 22019697].
  • 8. Peres LA, da Cunha AD Jr. Acute nephrotoxicity of cisplatin: Molecular mechanisms. J Bras Nefrol. 2013;35(4):332-40. doi: 10.5935/0101-2800.20130052. [PubMed: 24402113].
  • 9. Heyman SN, Rosen S, Rosenberger C. A role for oxidative stress. Contrib Nephrol. 2011;174:138-48. doi: 10.1159/000329383. [PubMed: 21921618].
  • 10. Nakhai LA, Mohammadirad A, Yasa N, Minaie B, Nikfar S, Ghazanfari G, et al. Benefits of Zataria multiflora Boiss in experimental model of mouse inflammatory bowel disease. Evid Based Complement Alternat Med. 2007;4(1):43-50. doi: 10.1093/ecam/nel051. [PubMed: 17342240]. [PubMed Central: PMC1810372].
  • 11. Hosseinimehr SJ, Mahmoudzadeh A, Ahmadi A, Ashrafi SA, Shafaghati N, Hedayati N. The radioprotective effect of Zataria multiflora against genotoxicity induced by gamma irradiation in human blood lymphocytes. Cancer Biother Radiopharm. 2011;26(3):325-9. doi: 10.1089/cbr.2010.0896. [PubMed: 21711107].
  • 12. Hosseinimehr SJ, Ahmadashrafi S, Naghshvar F, Ahmadi A, Ehasnalavi S, Tanha M. Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Integr Cancer Ther. 2010;9(2):219-23. doi: 10.1177/1534735409360361. [PubMed: 20356951].
  • 13. Sharififar F, Moshafi MH, Mansouri SH, Khodashenas M, Khoshnoodi M. In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss. Food Control. 2007;18(7):800-5. doi: 10.1016/j.foodcont.2006.04.002.
  • 14. Sajed H, Sahebkar A, Iranshahi M. Zataria multiflora Boiss. (Shirazi thyme)--an ancient condiment with modern pharmaceutical uses. J Ethnopharmacol. 2013;145(3):686-98. doi: 10.1016/j.jep.2012.12.018. [PubMed: 23266333].
  • 15. Kruk I, Michalska T, Lichszteld K, Kladna A, Aboul-Enein HY. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere. 2000;41(7):1059-64. [PubMed: 10879823].
  • 16. Arab HA, Fathi M, Mortezai E, Hosseinimehr SJ. Chemoprotective effect of thymol against genotoxicity induced by bleomycin in human lymphocytes. Pharm Biomed Res. 2015;1(1):26-31. doi: 10.18869/acadpub.pbr.1.1.26.
  • 17. Hosseinimehr SJ, Asadian R, Naghshvar F, Azizi S, Jafarinejad M, Noaparast Z, et al. Protective effects of thymol against nephrotoxicity induced by cisplatin with using 99mTc-DMSA in mice. Ren Fail. 2015;37(2):280-4. doi: 10.3109/0886022X.2014.991998. [PubMed: 25540869].
  • 18. Aghamohammadi A, Azadbakht M, Hosseinimehr SJ. Quantification of thymol content in different extracts of Zataria multiflora by HPLC method. Pharm Biomed Res. 2016;2(1):8-13. doi: 10.18869/acadpub.pbr.2.1.8.
  • 19. Aghamohammadi A, Hosseinimehr SJ, Ghasemi A, Azadbakht M, Pourfallah TA. Radiosensitization effects of a Zataria multiflora extract on human glioblastoma cells. Asian Pac J Cancer Prev. 2015;16(16):7285-90. [PubMed: 26514525].
  • 20. Ajith TA, Usha S, Nivitha V. Ascorbic acid and alpha-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: A comparative study. Clin Chim Acta. 2007;375(1-2):82-6. doi: 10.1016/j.cca.2006.06.011. [PubMed: 16889761].
  • 21. Nasiry Zarrin Ghabaee D, Talebpour Amiri F, Esmaeelnejad Moghaddam A, Khalatbary AR, Zargari M. Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model. J Nephropathol. 2017;6(2):74-80. doi: 10.15171/jnp.2017.13. [PubMed: 28491857]. [PubMed Central: PMC5418074].
  • 22. Naeimi RA, Talebpour Amiri F, Khalatbary AR, Ghasemi A, Zargari M, Ghesemi M, et al. Atorvastatin mitigates testicular injuries induced by ionizing radiation in mice. Reprod Toxicol. 2017;72:115-21. doi: 10.1016/j.reprotox.2017.06.052. [PubMed: 28668617].
  • 23. Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: A review. Am J Med Sci. 2007;334(2):115-24. doi: 10.1097/MAJ.0b013e31812dfe1e. [PubMed: 17700201].
  • 24. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014;141(2):150-9. doi: 10.1016/j.pharmthera.2013.09.006. [PubMed: 24080471].
  • 25. Fatima S, Al-Mohaimeed N, Al-Shaikh Y, Tyagi P, Banu N, Hasan S, et al. Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin-induced nephrotoxicity via suppression of oxidative/nitrosative stress, inflammation and cellular damage. Food Chem Toxicol. 2016;94:213-20. doi: 10.1016/j.fct.2016.05.023. [PubMed: 27265264].
  • 26. Hagar H, Medany AE, Salam R, Medany GE, Nayal OA. Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative/nitrosative stress and suppression of inflammation and apoptosis in rats. Exp Toxicol Pathol. 2015;67(2):133-41. doi: 10.1016/j.etp.2014.11.001. [PubMed: 25488130].
  • 27. El-Sayed EM, Abd-Allah AR, Mansour AM, El-Arabey AA. Thymol and carvacrol prevent cisplatin-induced nephrotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J Biochem Mol Toxicol. 2015;29(4):165-72. doi: 10.1002/jbt.21681. [PubMed: 25487789].
  • 28. Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F. Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother. 2017;85:7-15. doi: 10.1016/j.biopha.2016.11.110. [PubMed: 27930989].
  • 29. Hajihashemi S, Jafarian T, Ahmadi M, Rahbari A, Ghanbari F. Ameliorative effects of Zataria multiflora hydro-alcoholic extract on gentamicin induced nephrotoxicity in rats. Drug Res (Stuttg). 2018;68(7):387-94. doi: 10.1055/s-0043-124968. [PubMed: 29341028].
  • 30. Ahmadipour A, Sharififar F, Nakhaipour F, Samanian M, Karami-Mohajeri S. Hepatoprotective effect of Zataria multiflora Boisson cisplatin-induced oxidative stress in male rat. J Med Life. 2015;8(Spec Iss 4):275-81. [PubMed: 28316744]. [PubMed Central: PMC5319274].
  • 31. Pabla N, Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int. 2008;73(9):994-1007. doi: 10.1038/sj.ki.5002786. [PubMed: 18272962].
  • 32. Bratton SB, Cohen GM. Apoptotic death sensor: An organelle's alter ego? Trends Pharmacol Sci. 2001;22(6):306-15. [PubMed: 11395159].
  • 33. Razzaque MS. Cisplatin nephropathy: Is cytotoxicity avoidable? Nephrol Dial Transplant. 2007;22(8):2112-6. doi: 10.1093/ndt/gfm378. [PubMed: 17617652].
  • 34. Cummings BS, Schnellmann RG. Cisplatin-induced renal cell apoptosis: Caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002;302(1):8-17. [PubMed: 12065694].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments