Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Effect of Oral Minocycline on Clinical Recovery Process in Patients with Acute Ischemic Stroke: A Randomized Clinical Trial

Gholamreza Shamsaei 1 , * and Payam Mohammadi 1
Authors Information
1 Neurology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2017, 12 (3); e63792
  • Published Online: August 31, 2017
  • Article Type: Research Article
  • Received: December 10, 2016
  • Revised: February 8, 2017
  • Accepted: February 19, 2017
  • DOI: 10.5812/jjnpp.63792

To Cite: Shamsaei G, Mohammadi P. Effect of Oral Minocycline on Clinical Recovery Process in Patients with Acute Ischemic Stroke: A Randomized Clinical Trial, Jundishapur J Nat Pharm Prod. 2017 ; 12(3):e63792. doi: 10.5812/jjnpp.63792.

Copyright © 2017, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Gorelick AR, Gorelick PB, Sloan EP. Emergency department evaluation and management of stroke: acute assessment, stroke teams and care pathways. Neurol Clin. 2008; 26(4): 923-42[DOI][PubMed]
  • 2. Grysiewicz RA, Thomas K, Pandey DK. Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors. Neurol Clin. 2008; 26(4): 871-95[DOI][PubMed]
  • 3. Hosseini AA, Sobhani-Rad D, Ghandehari K, Benamer HT. Frequency and clinical patterns of stroke in Iran - Systematic and critical review. BMC Neurol. 2010; 10: 72[DOI][PubMed]
  • 4. Markus H. Stroke: causes and clinical features. Medicine. 2008; 36(11): 586-91[DOI]
  • 5. Montagu A, Reckless IP, Buchan AM. Stroke: management and prevention. Medicine. 2012; 40(9): 490-9[DOI]
  • 6. Gbinigie II, Reckless IP, Buchan AM. Stroke: management and prevention. Medicine. 2016; 44(9): 521-9[DOI]
  • 7. Ghandehari K. Design of a standard Iranian protocol of Intravenous thrombolysis with tissue plasminogen activator: A national project. Iran J Neurol. 2013; 12(2): 72-4[PubMed]
  • 8. Park MK, Smith PC, Wanserski GR. Aspirin in patients with acute ischemic stroke. Clinical Inquiries. 2009;
  • 9. Fagan SC, Cronic LE, Hess DC. Minocycline development for acute ischemic stroke. Transl Stroke Res. 2011; 2(2): 202-8[DOI][PubMed]
  • 10. Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007; 69(14): 1404-10[DOI][PubMed]
  • 11. Kohler E, Prentice DA, Bates TR, Hankey GJ, Claxton A, van Heerden J, et al. Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis. Stroke. 2013; 44(9): 2493-9[DOI][PubMed]
  • 12. Yang F, Zhou L, Wang D, Wang Z, Huang QY. Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1alpha through SIRT-3/PHD-2 degradation pathway. Neuroscience. 2015; 304: 250-9[DOI][PubMed]
  • 13. Dong W, Xiao S, Cheng M, Ye X, Zheng G. Minocycline induces protective autophagy in vascular endothelial cells exposed to an in vitro model of ischemia/reperfusion-induced injury. Biomed Rep. 2016; 4(2): 173-7[DOI][PubMed]
  • 14. Amiri-Nikpour MR, Nazarbaghi S, Hamdi-Holasou M, Rezaei Y. An open-label evaluator-blinded clinical study of minocycline neuroprotection in ischemic stroke: gender-dependent effect. Acta Neurol Scand. 2015; 131(1): 45-50[DOI][PubMed]
  • 15. Padma Srivastava MV, Bhasin A, Bhatia R, Garg A, Gaikwad S, Prasad K, et al. Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled trial. Neurol India. 2012; 60(1): 23-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments