Jundishapur Journal of Natural Pharmaceutical Products

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The Effects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients

Homeira Rashidi 1 , * , Foroogh Namjoyan 2 , Zahra Mehraban 1 , Mehrnoosh Zakerkish 1 , Seyed Bahman Ghaderian 1 and Seyed Mahmoud Latifi 1
Authors Information
1 Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran
2 Pharmacognosy Department and Traditional Iranian Pharmacy Department, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 2018, 13 (1); e64180
  • Published Online: February 24, 2018
  • Article Type: Research Article
  • Received: September 18, 2016
  • Revised: November 18, 2017
  • Accepted: February 20, 2018
  • DOI: 10.5812/jjnpp.64180

To Cite: Rashidi H, Namjoyan F, Mehraban Z, Zakerkish M, Ghaderian S B, et al. The Effects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients, Jundishapur J Nat Pharm Prod. 2018 ; 13(1):e64180. doi: 10.5812/jjnpp.64180.

Copyright © 2018, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Afkhami-Ardekani M, Kamali-Ardakani A. Study of the effect of garlic on serum lipids and blood Glucose levels in type 2 diabetic patients. J Shahid Sadoughi Univ Med Sci Health Serv. 2005;13(1):8-11.
  • 2. Zamani Nour N, Tahbaz F, Taleban F, Alavi Majd H, Neyestani T. Effects of garlic ingestion with breakfast on postprandial serum glucose and insulin in type 2 diabetic patients [In Persian]. Iran J Nutr Sci Food Technol. 2007;1(3):39-44.
  • 3. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081. [PubMed: 24357215].
  • 4. Azizi F, Guoya MM, Vazirian P, Dolatshati P, Habbibian S. Screening for type 2 diabetes in the Iranian national programme: a preliminary report. East Mediterr Health J. 2003;9(5-6):1122-7. [PubMed: 16450546].
  • 5. Hadaegh F, Bozorgmanesh MR, Ghasemi A, Harati H, Saadat N, Azizi F. High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. BMC Public Health. 2008;8:176. doi: 10.1186/1471-2458-8-176. [PubMed: 18501007].
  • 6. Esteghamati A, Gouya MM, Abbasi M, Delavari A, Alikhani S, Alaedini F, et al. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care. 2008;31(1):96-8. doi: 10.2337/dc07-0959. [PubMed: 17921357].
  • 7. Delavari A, Alikhani S, Nili S, Birjandi RH, Birjandi F. Quality of care of diabetes mellitus type II patients in Iran. Arch Iran Med. 2009;12(5):492-5. [PubMed: 19722773].
  • 8. Ayoubi A, Omidi A, Valizade R, Mousaei A. Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats [In Persian]. J Birjand Univ Med Sci. 2013;20(2):144-52.
  • 9. Mozaffari-Khosravi H, Jalali B, Afkhami-Ardakani M. Effect of Sour tea (Hibiscus sabdariffa) on blood glucose, lipid profile and lipoproteins in diabetics [In Persian]. Iran J Endocrinol Metab. 2009;10(6):589-97.
  • 10. Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res. 2008;22(8):999-1012. doi: 10.1002/ptr.2399. [PubMed: 18618524].
  • 11. Yin J, Ye J, Jia W. Effects and mechanisms of berberine in diabetes treatment. Acta Pharm Sin B. 2012;2(4):327-34. doi: 10.1016/j.apsb.2012.06.003.
  • 12. Ma X, Egawa T, Kimura H, Karaike K, Masuda S, Iwanaka N, et al. Berberine-induced activation of 5'-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles. Metabolism. 2010;59(11):1619-27. doi: 10.1016/j.metabol.2010.03.009. [PubMed: 20423742].
  • 13. Gu Y, Zhang Y, Shi X, Li X, Hong J, Chen J, et al. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta. 2010;81(3):766-72. doi: 10.1016/j.talanta.2010.01.015. [PubMed: 20298851].
  • 14. Zhang H, Wei J, Xue R, Wu JD, Zhao W, Wang ZZ, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism. 2010;59(2):285-92. doi: 10.1016/j.metabol.2009.07.029. [PubMed: 19800084].
  • 15. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013. [PubMed: 18442638].
  • 16. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2559-65. doi: 10.1210/jc.2007-2404. [PubMed: 18397984].
  • 17. Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi: 10.1155/2012/591654. [PubMed: 23118793].
  • 18. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. doi: 10.2147/DMSO.S33718. [PubMed: 22924000].
  • 19. Meliani N, Dib Mel A, Allali H, Tabti B. Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed. 2011;1(6):468-71. doi: 10.1016/S2221-1691(11)60102-0. [PubMed: 23569815].
  • 20. Ebrahimi-Mamaghani M, Arefhosseini SR, Golzarand <, Aliasgarzadeh A, Vahed-Jabbary M. Long-term effects of processed berberis vulgaris on some metabolic syndrome components [In Persian]. Iran J Endocrinol Metab. 2009;11(1):41-7.
  • 21. Golzarand M, Ebrahimi-Mamaghani M, Arefhosseini S, Asgarzadeh AA. Effect of processed Berberis vulgaris in apple vinegar on blood pressure and inflammatory markers in type 2 diabetic patients. J Diabete Metab Disord. 2008;8:15-20.

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