Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Ameliorative Effects of Red Lentil Extract on Sodium Arsenite-induced Oxidative Stress in Rats

Heibatullah Kalantari 1 , Gholamreza Houshmand 2 , Amin Hasanvand 3 , Mojtaba Kalantar 4 , Mehdi Goudarzi 1 , 5 , * and Hossein Khadem Haghighian 6
Authors Information
1 Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pharmacology, School of Medicine, Mazandaran university of Medical Sciences, Sari, Iran
3 Department of Pharmacology, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Shoushtar Faculty of Medical Sceinces, Shoushtar, Iran
5 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
6 Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, IR Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2017, 12 (3 (Supp)); e64309
  • Published Online: August 31, 2017
  • Article Type: Research Article
  • Received: December 29, 2015
  • Revised: November 13, 2016
  • Accepted: December 5, 2016
  • DOI: 10.5812/jjnpp.64309

To Cite: Kalantari H, Houshmand G, Hasanvand A, Kalantar M, Goudarzi M, et al. Ameliorative Effects of Red Lentil Extract on Sodium Arsenite-induced Oxidative Stress in Rats, Jundishapur J Nat Pharm Prod. 2017 ; 12(3 (Supp)):e64309. doi: 10.5812/jjnpp.64309.

Copyright © 2017, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
5. Conclusions
  • 1. Balakumar B, Kumaresan S, Venugopal R, Sivasubramanian V. Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E. Indian J Sci Technol. 2010;3(6):642-7.
  • 2. Amayo KO, Raab A, Krupp EM, Marschall T, Horsfall MJ, Feldmann J. Arsenolipids show different profiles in muscle tissues of four commercial fish species. J Trace Elem Med Biol. 2014;28(2):131-7. doi: 10.1016/j.jtemb.2013.11.004. [PubMed: 24332310].
  • 3. Kulshrestha A, Jarouliya U, Prasad GBKS, Flora SJS, Bisen PS. Arsenic induced abnormalities in glucose metabolism, biochemical basis and potential therapeutic and nutritional interventions. World J Transl Med. 2014;3(2):96. doi: 10.5528/wjtm.v3.i2.96.
  • 4. French VM, Cooper RA, Molan PC. The antibacterial activity of honey against coagulase negative staphylococci. J Antimicrob Chemother. 2005;56(1):228-31. doi: 10.1093/jac/dki193. [PubMed: 15941774].
  • 5. Xie H, Huang S, Martin S, Wise JS. Arsenic is cytotoxic and genotoxic to primary human lung cells. Mutat Res Genet Toxicol Environ Mutagen. 2014;760:33-41. doi: 10.1016/j.mrgentox.2013.11.001. [PubMed: 24291234].
  • 6. Agusa T, Trang PT, Lan VM, Anh DH, Tanabe S, Viet PH, et al. Human exposure to arsenic from drinking water in Vietnam. Sci Total Environ. 2014;488-489:562-9. doi: 10.1016/j.scitotenv.2013.10.039. [PubMed: 24262873].
  • 7. Muhammad A, Odunola OA, Gbadegesin MA, Adegoke AM, Olugbami JO, Uche NS. Modulatory role of acacia honey from north west nigeria on sodium arsenite induced clastogenicity and oxidative stress in male wistar rats. Nat Prod Res. 2015;29(4):321-6. doi: 10.1080/14786419.2014.940945. [PubMed: 25105348].
  • 8. Odunola OA, Akinwumi KA, Ogunbiyi B, Tugbobo O. Interaction and enhancement of the toxic effects of sodium arsenite and lead acetate in wistar rats. Afr J Biomed Res. 2007;10(1). doi: 10.4314/ajbr.v10i1.48972.
  • 9. Sharma A, Sharma MK, Kumar M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem Biol Interact. 2009;180(1):20-30. doi: 10.1016/j.cbi.2009.01.012. [PubMed: 19428342].
  • 10. Aruoma OI, Somanah J, Bourdon E, Rondeau P, Bahorun T. Diabetes as a risk factor to cancer: functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer. Mutat Res. 2014;768:60-8. doi: 10.1016/j.mrfmmm.2014.04.007. [PubMed: 24769427].
  • 11. Youn UJ, Miklossy G, Chai X, Wongwiwatthananukit S, Toyama O, Songsak T, et al. Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea. Fitoterapia. 2014;93:194-200. doi: 10.1016/j.fitote.2013.12.013. [PubMed: 24370662].
  • 12. Murphy MP. Antioxidants as therapies: can we improve on nature?. Free Radic Biol Med. 2014;66:20-3. doi: 10.1016/j.freeradbiomed.2013.04.010. [PubMed: 23603661].
  • 13. Schloss JM, Vitetta L. Antioxidants to abrogate free radicals, new insights to challenge currently held beliefs. Aust J Herb Med. 2014;26(1):4.
  • 14. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 2002;113 Suppl 9B:71-88. [PubMed: 12566142].
  • 15. Giuseppe DD, Wolk A. Diet and rheumatoid arthritis development, what does the evidence say?. Int J Clin Rheumtol. 2014;9(2):169-82. doi: 10.2217/ijr.14.9.
  • 16. Amarowicz R, Troszynska A, Shahidi F. Antioxidant activity of almond seed extract and its fractions. J Food Lipids. 2005;12(4):344-58. doi: 10.1111/j.1745-4522.2005.00029.x.
  • 17. Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H, Lindsted KD. Effects of walnuts on serum lipid levels and blood pressure in normal men. N Engl J Med. 1993;328(9):603-7. doi: 10.1056/NEJM199303043280902. [PubMed: 8357360].
  • 18. Zou Y, Chang SK, Gu Y, Qian SY. Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions. J Agric Food Chem. 2011;59(6):2268-76. doi: 10.1021/jf104640k. [PubMed: 21332205].
  • 19. Amarowicz R, Pegg RB. Legumes as a source of natural antioxidants. Eur J Lipid Sci Technol. 2008;110(10):865-78. doi: 10.1002/ejlt.200800114.
  • 20. Madhujith T, Amarowicz R, Shahidi F. Phenolic antioxidants in beans and their effects on inhibition of radical induced DNA damage. J Am Oil Chem Soc. 2004;81(7):691-6. doi: 10.1007/s11746-004-963-y.
  • 21. Amarowicz R, Troszynska, A . Antioxidant activity of extract of pea and its fractions of low molecular phenolics and tannins. Pol J Food Nutr Sci. 2003;12(53):10-5.
  • 22. Amarowicz R, Troszynska A, Pegg RB. Antioxidative and radical scavenging effects of phenolics from Vicia sativum. Fitoterapia. 2008;79(2):121-2. doi: 10.1016/j.fitote.2007.07.018. [PubMed: 18178017].
  • 23. Van Duyn MA, Pivonka E. Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc. 2000;100(12):1511-21. doi: 10.1016/S0002-8223(00)00420-X. [PubMed: 11138444].
  • 24. Kim SK, Wijesekara I. Development and biological activities of marine derived bioactive peptides, a review. J Funct Foods. 2010;2(1):1-9. doi: 10.1016/j.jff.2010.01.003.
  • 25. Zhang Z, Liao L, Moore J, Wu T, Wang Z. Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem. 2009;113(1):160-5. doi: 10.1016/j.foodchem.2008.07.061.
  • 26. Rahmani A, Goudarzi M, Rashidi Nooshabadi M, Houshmand G, Khadem Haghighian H. Protective effect of red lentil, (lens culinaris) extract against carbon tetrachloride induced hepatotoxicity in mice. J Babol Univ Med Sci. 2014;16(2):49-55.
  • 27. Amarowicz R, Pegg RB, Rahimi Moghaddam P, Barl B, Weil JA. Free radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food Chem. 2004;84(4):551-62. doi: 10.1016/s0308-8146(03)00278-4.
  • 28. Kadirvel R, Sundaram K, Mani S, Samuel S, Elango N, Panneerselvam C. Supplementation of ascorbic acid and alpha-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats. Hum Exp Toxicol. 2007;26(12):939-46. doi: 10.1177/0960327107087909. [PubMed: 18375637].
  • 29. Rodriguez VM, Carrizales L, Jimenez-Capdeville ME, Dufour L, Giordano M. The effects of sodium arsenite exposure on behavioral parameters in the rat. Brain Res Bull. 2001;55(2):301-8. [PubMed: 11470331].
  • 30. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1):248-54. [PubMed: 942051].
  • 31. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56-63. [PubMed: 13458125].
  • 32. King J. The phosphohydrolases and alkaline phosphatases, practical clinical enzymology. London: Van Nostrand Company; 1965.
  • 33. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70-7. [PubMed: 13650640].
  • 34. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6. [PubMed: 6727660].
  • 35. Martin JJ, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys. 1987;255(2):329-36. [PubMed: 3036004].
  • 36. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302-10. [PubMed: 672633].
  • 37. Tokar EJ, Kojima C, Waalkes MP. Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic. Arch Toxicol. 2014;88(2):249-61. doi: 10.1007/s00204-013-1141-2. [PubMed: 24091636].
  • 38. Bodhank SL, Adil M, Visnagri A, Kumar VS, Kandhar AD, Ghosh P. Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats. Pharmacologia. 2014;5(6):222-34. doi: 10.5567/pharmacologia.2014.222.234.
  • 39. Goyal S, Deepak K, Reddy P, Pradeep K, Swapna LA. Antioxidants and their implication in oral health and general health. Int J Case Rep Imag. 2014;5(4):258-63. doi: 10.5348/ijcri-201555-RA-10010.
  • 40. Amarowicz R, Estrella I, Hernandez T, Duenas M, Troszynska A, Agnieszka K, et al. Antioxidant activity of a red lentil extract and its fractions. Int J Mol Sci. 2009;10(12):5513-27. doi: 10.3390/ijms10125513. [PubMed: 20054484].
  • 41. Xu BJ, Chang SK. A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. J Food Sci. 2007;72(2):S159-66. doi: 10.1111/j.1750-3841.2006.00260.x. [PubMed: 17995858].
  • 42. Deshpande SS. Food legumes in human nutrition: a personal perspective. Crit Rev Food Sci Nutr. 1992;32(4):333-63. doi: 10.1080/10408399209527603. [PubMed: 1297325].
  • 43. Faris MAIE, Takruri HR, Issa AY. Role of lentils, (Lens culinaris L.) in human health and nutrition, a review. Med J Nutrition Metab. 2013;6(1):3-16. doi: 10.1007/s12349-012-0109-8.
  • 44. Houshmand G, Tarahomi S, Arzi A, Goudarzi M, Bahadoram M, Rashidi-Nooshabadi M. Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats. J Clin Diagn Res. 2016;10(6):5-8. doi: 10.7860/JCDR/2016/17813.7977. [PubMed: 27504309].
  • 45. Kerner A, Avizohar O, Sella R, Bartha P, Zinder O, Markiewicz W, et al. Association between elevated liver enzymes and C-reactive protein: possible hepatic contribution to systemic inflammation in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2005;25(1):193-7. doi: 10.1161/01.ATV.0000148324.63685.6a. [PubMed: 15499043].
  • 46. Aghel N, Kalantari H, Rezazadeh S. Hepatoprotective effect of Ficus carica leaf extract on mice intoxicated with carbon tetrachloride. Iran J Pharm Res. 2011;10(1):63-8. [PubMed: 24363682].
  • 47. Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem Toxicol. 2007;45(9):1551-7. doi: 10.1016/j.fct.2007.06.007. [PubMed: 17658209].
  • 48. Kalantari H, Aghel N, Bayati M. Hepatoprotective effect of Morus alba L. in carbon tetrachloride induced hepatotoxicity in mice. Saudi Pharmaceut J. 2009;17(1):90-4.
  • 49. Omale J, Okafor PN. Comparative antioxidant capacity, membrane stabilization, polyphenol composition and cytotoxicity of the leaf and stem of Cissus multistriata. African J Biotechnol. 2008;7(17).
  • 50. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol. 2011;31(2):95-107. doi: 10.1002/jat.1649. [PubMed: 21321970].
  • 51. El-Demerdash FM, Yousef MI, Radwan FM. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol. 2009;47(1):249-54. doi: 10.1016/j.fct.2008.11.013. [PubMed: 19049818].
  • 52. Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res. 2008;128(4):501-23. [PubMed: 19106443].
  • 53. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014;94(2):329-54. doi: 10.1152/physrev.00040.2012. [PubMed: 24692350].
  • 54. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18(10):872-9. [PubMed: 12361782].
  • 55. Sachdeva S, Flora SJ. Efficacy of some antioxidants supplementation in reducing oxidative stress post sodium tungstate exposure in male wistar rats. J Trace Elem Med Biol. 2014;28(2):233-9. doi: 10.1016/j.jtemb.2014.01.004. [PubMed: 24613855].
  • 56. Aquilano K, Baldelli S, Ciriolo MR. Glutathione, new roles in redox signaling for an old antioxidant. Front Pharmacol. 2014;5:196. doi: 10.3389/fphar.2014.00196. [PubMed: 25206336].
  • 57. Feng S, Deng H .Zheng X; Wang D; Gong Y; Wang Q. Systematic analysis of reactivities and fragmentation of glutathione and its isomer Glucysgly. J Phys Chem A. 2014;118(37):8222-8. doi: 10.1021/jp501015k. [PubMed: 24734962].
  • 58. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998;56(11):317-33. [PubMed: 9838798].
  • 59. Shen DS, Tao XQ, Shen CC, Shentu JL, Wang MZ. Antioxidant defense enzymes response following polychlorinated biphenyls exposure to eisenia fetida in actual polluted soil. Adv Mater Res. 2014;1010:142-6. doi: 10.4028/www.scientific.net/AMR.1010-1012.142.
  • 60. Amarowicz R, Estrella I, Hernandez T, Robredo S, Troszynska A, Kosinska A, et al. Free radical scavenging capacity, antioxidant activity, and phenolic composition of green lentil, (Lens culinaris). Food Chem. 2010;121(3):705-11. doi: 10.1016/j.foodchem.2010.01.009.
  • 61. Denev P, Kratchanova M, Ciz M, Lojek A, Vasicek O, Nedelcheva P, et al. Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health. Food Chem. 2014;157:37-44. doi: 10.1016/j.foodchem.2014.02.022. [PubMed: 24679749].
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