PROMOTION OF WOUND HEALING BY HYPERICUM PERFORATUM EXTRACT IN RABBIT

AUTHORS

AA Hemmati 1 , * , I Rashidi 2 , M Jafari 2

1 Department of Pharmacology &Toxicology, School of Pharmacy and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, Hemmati_aa@yahoo.com, Iran

2 2Department of Pathology, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Iran

How to Cite: Hemmati A, Rashidi I, Jafari M. PROMOTION OF WOUND HEALING BY HYPERICUM PERFORATUM EXTRACT IN RABBIT, Jundishapur J Nat Pharm Prod. Online ahead of Print ; 2(2):78-86.

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 2 (2); 78-86
Article Type: Research Article
Received: November 13, 2007
Accepted: December 15, 2007

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Abstract

The aim of this work was to evaluate the effect of hydroalcoholic extract of Hypericum perforatum  (St John's Wort) (SJW) on wound healing in rabbit. Wound surface area and histopathological changes following topical application of various concentartions of SJW extract (2, 5 and 10% w/w) in eucerin base were tested on full thickness excision wound in rabbit. Such effect was compared with phenytoin cream (1%) as a standard healing agent. SJW extract significantly reduced the rate of wound healing compared to no-treatment, eucerin or phenytoin treated groups. 2% SJW extract cream showed better healing profile, and the rate of healing was significantly (p<0.01) shorter than other groups. SJW  showed a considerable potential for wound healing possibly by promotion of fibroblast and myofibroblasts proliferation which results in higher rate of wound closure.

Keywords

Saint John's Wort, Wound healing, Full thickness wound, Hydroalcoholic extract, Rabbit.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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