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REVIEW ON T-2 TOXIN

AUTHORS

H Kalantari 1 , * , M Moosavi 2

AUTHORS INFORMATION

1 Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Kalantarih@yahoo.com, Iran

2 Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Iran

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 5 (1); 26-38
Article Type: Review Article
Received: June 28, 2010
Accepted: October 23, 2010

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Abstract

T-2 toxin is a member of the fungal metabolites known as trichothecene mycotoxin. The major attribute of T-2 toxin is that it inhibit protein synthesis which is followed by a secondary disruption of DNA and RNA synthesis. T-2 toxin affects the actively dividing cells such as those lining the gastrointestinal tract, skin, lymphoid and erythroid cells. It can decrease antibody levels, immunoglobolines and certain other humoral factors. In addition, in this review article acute and chronic effects on health, toxicokinetics, regulatory matters related to its use as a potential warfare and treatment strategies that may be undertaken will be briefly covered.

Keywords

Fusarium fungi, T-2 toxin, Health issue.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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