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THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

AUTHORS

A Arzi 1 , * , AA Hemmati 2 , S Ghobishavi 2 , L Arzi 3

AUTHORS INFORMATION

1 Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, arzi_ardeshir@yahoo.com, Iran

2 Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, Iran

3 Institute of Biophysics and Biochemistry, Tehran University, Iran

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 2 (1); 18-24
Article Type: Research Article
Received: February 21, 2006
Accepted: July 20, 2007

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Abstract

Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.

Keywords

L-tyrosine, Vitamin E, Vitamin C, Perphenazine, Catatonia, Rat.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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