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Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

AUTHORS

Ardeshir Arzi 1 , Behnam Ghorbanzadeh 2 , * , Zahra Nazari Khorasgani 2

AUTHORS INFORMATION

1 Department of Pharmacology and Toxicology, School of Pharmacy, Physiology Research Center, Jundishapur University of Medical Sciences, IR Iran

2 Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, b_ghorbanzadeh82@yahoo.com, IR Iran

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 8 (1); 10-14
Published Online: February 13, 2013
Article Type: Research Article
Received: July 25, 2012
Accepted: October 20, 2012
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Abstract

Background: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain.

Objectives: To investigate the antinociceptive activity of Iranian green tea extract.

Materials and Methods: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection.

Results: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1.

Conclusions: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.

Keywords

Green Tea Antinociception Formalin Test Rat

© 2013, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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