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AN IN VITRO STUDY ON THE EFFECT OF HISTAMINE ON THE CONTRACTILE RESPONSIVENESS OF RAT SUBCUTANEOUS FASCIA AND WOUND GRANULATION TISSUE TO MEPYRAMINE

AUTHORS

MH Pipelzadeh 1 , * , IL Naylor 2 , 3

AUTHORS INFORMATION

1 Department of Pharmacology, School of Medicine, Ahwaz University of Medical Sciences, mhpipelzadeh@yahoo.com, Iran

2 Postgraduate School of Studied in Pharmacology, School of Pharmacy, University of Bradford, Bradford, UK

3

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 2 (2); 105-110
Article Type: Research Article
Received: September 16, 2007
Accepted: October 31, 2007

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Abstract

Myofibroblasts play an important central role in wound contraction and repair, and are believed to develop from resident fibroblasts in the adjacent uninjured connective tissues. However, the factors involved in their differentiation into more contractile cells are not fully understood. The aim of the present study was to elucidate the role of histamine on the pharmacological responsiveness of both subcutaneous fascia and wound granulation tissues. In the present in vitro study, using superfusion technique, the effects of histamine (1, 10 and 50 µM following 30 and 60 min incubation) on the pharmacological responsiveness of excisional wound granulation tissue were compared with superficial fascia to mepyramine. The results showed that incubation with histamine caused an increase in responsiveness of normal fascia to mepyramine, while it had no effect on excisional wound granulation tissue. In conclusion, it seems that histamine plays an important role in modulating the contractile behaviour of the normal fibroblasts and promotes the development of a more contractile cell resembling the myofibroblasts.

Keywords

Histamine, Mepyramine, Contractility, Subcutaneous fascia, Wound granulation tissue, Wound healing, Rat.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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