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ISOLATION OF A NEW MODERATELY HALOPHILIC BROAD-SPECTRUM ANTIBIOTIC PRODUCING ACTINOBACTER

AUTHORS

J Hamedi 1 , * , F Mohammadipanah 2 , MA Amoozegar 2 , S Dehghan 2

AUTHORS INFORMATION

1 Microbial Biotechnology laboratory, Department of Microbiology, School of Biology, College of Science, University of Tehran, jhamedi@khayam.ut.ac.ir, Iran

2 Microbial Biotechnology laboratory, Department of Microbiology, School of Biology, College of Science, University of Tehran, Iran

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 2 (2); 94-104
Article Type: Research Article
Received: June 26, 2007
Accepted: November 29, 2007

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Abstract

In a screening program for antibiotic producer rare-actinobacteria from soil of Iran, a novel moderately halophilic actinobacter (Q70) was isolated. The strain had the ability of antibiotic production against methicillin resistant Staphylococcus aureus. Maximum antibiotic production was obtained in the medium containing 10% (w/v) NaCl. The strain Q70 had also activity against Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa. The antibiotic extracted from fermentation broth had low toxicity (681/3 μg/ml LC50) against Artemia salina in brine shrimp lethality test. The antibiotic produced by strain Q70 had polar structure. The strain Q70 is proposed as a new species with the name of Nocardiopsis iraniensis with considering the significant morphological, physiological, molecular and chemotaxonomical differences between Q70 and other species of Nocardiopsis.

Keywords

Actinobacteria, Antibiotic, Halophile, MRSA, Nocardiopsis, Pseudomonas aeruginosa.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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