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SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS

AUTHORS

MA Dabbagh 1 , * , L Beitmashal 2

1 School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Dabbaghma@yahoo.com

2 School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences

How to Cite: Dabbagh M, Beitmashal L. SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS , Jundishapur J Nat Pharm Prod. Online ahead of Print ; 1(1):1-7.

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 1 (1); 1-7
Article Type: Research Article
Received: May 29, 2004
Accepted: November 20, 2005

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Abstract

Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drug (NSAID) available in the market. To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, different formulations of ibuprofen containing different amounts of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (Avicel®) were made and evaluated. The superior formulation which released the drug at constant rate of about 60 mg/hour was chosen. Then the effect of changing particle size of granulation was studied. Two different crystal forms of ibuprofen were prepared and their release pattern were studied. Produced crystal forms of ibuprofen showed different release mechanisms in comparison with the original form.  Incorporation of various proportions of tween 80 and Sodium Lauryl Sulfate (SLS) as wetting agent on the release rate of ibuprofen in the formulations were also studied. Sodium lauryl sulphate disintegrated the tablets faster than tween 80.

Keywords

Ibuprofen, HPMC, Matrix tablets, Dissolution, Sodium Luryl Sulphate, Tween 80.

© 0, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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