Jundishapur Journal of Natural Pharmaceutical Products

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Hepatoprotective Effect of Aqueous Extract of Persian Gulf Brown Algae Sargassum swartzii Against Acetaminophen-Induced Hepatotoxicity in Mice

Mohammad Reza Masoudian Khouzani 1 , 2 , Mohammad Reza Shushizadeh 1 , 3 , * , Heibatullah Kalantari 4 and Ebrahim Rajabzadeh Ghotrami 1 , 5
Authors Information
1 Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Marine Pharmaceutical Science Research Centre, Ahvaz Jundishapur University of Medical Sciences, Iran
4 Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Halal Research Center of Islamic Republic of Iran, Tehran, Iran
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: February 28, 2019, 14 (1); e77168
  • Published Online: March 5, 2019
  • Article Type: Research Article
  • Received: May 9, 2018
  • Revised: June 28, 2018
  • Accepted: July 7, 2018
  • DOI: 10.5812/jjnpp.77168

To Cite: Masoudian Khouzani M R, Shushizadeh M R, Kalantari H, Rajabzadeh Ghotrami E . Hepatoprotective Effect of Aqueous Extract of Persian Gulf Brown Algae Sargassum swartzii Against Acetaminophen-Induced Hepatotoxicity in Mice, Jundishapur J Nat Pharm Prod. 2019 ; 14(1):e77168. doi: 10.5812/jjnpp.77168.

Copyright © 2019, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Rajasulochana P, Dhamotharan R, Krishnamoorthy P, Murugesan S. Antibacterial activity of the extracts of marine red and brown algae. J Am Sci. 2009;5(3):20-5.
  • 2. Mutawie HH, ElNaggar SMM. The protective effect of Sargassum crassifolia against Nimbecidine–induced hepatotoxicity and nephrotoxicity in Wistar rats. Life Sci J. 2013;10(4).
  • 3. Madkour FF, Khalil WF, Dessouki AA. Protective effect of ethanol extract of Sargassum dentifolium (Phaeophyceae) in carbon tetrachloride-induced hepatitis in rats. Int J Pharm Pharm Sci. 2012;4(3):637-41.
  • 4. Lahaye M, Kaeffer B. Seaweed dietary fibres: structure, physico-chemical and biological properties relevant to intestinal physiology. Sci Des Aliments. 1997;17(6):563-84.
  • 5. Holt M, Ju C. Drug-induced liver injury. In: Uetrecht J, editor. Adverse Drug Reactions. 196. Berlin, Heidelberg: Springer; 2010. p. 3-27. doi: 10.1007/978-3-642-00663-0_1.
  • 6. Rates SM. Plants as source of drugs. Toxicon. 2001;39(5):603-13. doi: 10.1016/S0041-0101(00)00154-9. [PubMed: 11072038].
  • 7. Fontana RJ, Seeff LB, Andrade RJ, Bjornsson E, Day CP, Serrano J, et al. Standardization of nomenclature and causality assessment in drug-induced liver injury: Summary of a clinical research workshop. Hepatology. 2010;52(2):730-42. doi: 10.1002/hep.23696. [PubMed: 20564754]. [PubMed Central: PMC3616501].
  • 8. Yeh ST, Lee CS, Chen JC. Administration of hot-water extract of brown seaweed Sargassum duplicatum via immersion and injection enhances the immune resistance of white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2006;20(3):332-45. doi: 10.1016/j.fsi.2005.05.008. [PubMed: 16005643].
  • 9. Dias PF, Siqueira JM Jr, Vendruscolo LF, de Jesus Neiva T, Gagliardi AR, Maraschin M, et al. Antiangiogenic and antitumoral properties of a polysaccharide isolated from the seaweed Sargassum stenophyllum. Cancer Chemother Pharmacol. 2005;56(4):436-46. doi: 10.1007/s00280-004-0995-7. [PubMed: 15902462].
  • 10. Paskaleva EE, Lin X, Duus K, McSharry JJ, Veille JC, Thornber C, et al. Sargassum fusiforme fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptase. Virol J. 2008;5:8. doi: 10.1186/1743-422X-5-8. [PubMed: 18197976]. [PubMed Central: PMC2267448].
  • 11. Kang JY, Khan MN, Park NH, Cho JY, Lee MC, Fujii H, et al. Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice. J Ethnopharmacol. 2008;116(1):187-90. doi: 10.1016/j.jep.2007.10.032. [PubMed: 18079077].
  • 12. Chen X, Nie W, Yu G, Li Y, Hu Y, Lu J, et al. Antitumor and immunomodulatory activity of polysaccharides from Sargassum fusiforme. Food Chem Toxicol. 2012;50(3-4):695-700. doi: 10.1016/j.fct.2011.11.015. [PubMed: 22120506].
  • 13. Meena B, Ezhilan RA, Rajesh R, Hussain AS, Ganesan B, An R. Antihepatotoxic potential of Sargassum polycystum (Phaeophyceae) on antioxidant defense status in D-galactosamine-induced hepatitis in rats. Afr J Biochem Res. 2008;2(2):51-5.
  • 14. Shao P, Chen X, Sun P. Chemical characterization, antioxidant and antitumor activity of sulfated polysaccharide from Sargassum horneri. Carbohydr Polym. 2014;105:260-9. doi: 10.1016/j.carbpol.2014.01.073. [PubMed: 24708979].
  • 15. Vijayabaskar P, Vaseela N, Thirumaran G. Potential antibacterial and antioxidant properties of a sulfated polysaccharide from the brown marine algae Sargassum swartzii. Chin J Nat Med. 2012;10(6):421-8. doi: 10.1016/S1875-5364(12)60082-X.
  • 16. Ye H, Wang K, Zhou C, Liu J, Zeng X. Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum. Food Chem. 2008;111(2):428-32. doi: 10.1016/j.foodchem.2008.04.012. [PubMed: 26047446].
  • 17. Fujimoto K, Kaneda T. Separation of antioxygenic (antioxidant) compounds from marine algae. In: Bird CJ, Ragan MA, editors. Eleventh International Seaweed Symposium. 22. Springer; 1984. p. 111-3. doi: 10.1007/978-94-009-6560-7_17.
  • 18. Xiaojun Y, Xiancui L, Chengxu Z, Xiao F. Prevention of fish oil rancidity by phlorotannins from Sargassum kjellmanianum. J Appl Phycol. 1996;8(3):201-3. doi: 10.1007/BF02184972.
  • 19. Ruperez P, Ahrazem O, Leal JA. Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem. 2002;50(4):840-5. doi: 10.1021/jf010908o. [PubMed: 11829654].
  • 20. Park PJ, Shahidi F, Jeon YJ. Antioxidant activities of enzymatic extracts from an edible seaweed Sargassum horneri using ESR spectrometry. J Food Lipids. 2004;11(1):15-27. doi: 10.1111/j.1745-4522.2004.tb00257.x.
  • 21. Anggadiredja J, Andyani R. Antioxidant activity of Sargassum polycystum (Phaeophyta) and Laurencia obtusa (Rhodophyta) from Seribu islands. J Appl Phycol. 1997;9(5):477. doi: 10.1023/A:100807562.
  • 22. Hu M, Zhang H, Feng B, Liu K, Guo S. Extraction of polysaccharides from Fomes officinalis Ames and their antitumor activity. Exp Ther Med. 2013;6(2):451-4. doi: 10.3892/etm.2013.1163. [PubMed: 24137206]. [PubMed Central: PMC3786837].
  • 23. Patra S, Muthuraman MS, Prabhu AR, Priyadharshini RR, Parthiban S. Evaluation of antitumor and antioxidant activity of Sargassum tenerrimum against Ehrlich ascites carcinoma in mice. Asian Pac J Cancer Prev. 2015;16(3):915-21. doi: 10.7314/APJCP.2015.16.3.915. [PubMed: 25735382].
  • 24. Sathivel A, Raghavendran HB, Devaki T. Hepatoprotective nature of seaweeds (Ulva lactuca/Gracilaria edulis) against liver injury induced by D-Galactosamine/endotoxin in rats. Seaweed Res Utiln. 2003;25(1-2):109-11.
  • 25. Hira K, Sultana V, Ara J, Ehteshamul-Haque S, Athar M. Hepatoprotective potential of three sargassum species from Karachi coast against carbon tetrachloride and acetaminophen intoxication. J Coastal Life Med. 2016;4(1):10-3. doi: 10.12980/jclm.4.2016j5-204.
  • 26. Ramarajan L, Somasundaram ST, Subramanian S, Pandian V. Nephroprotective effects of Colpomenia sinuosa (Derbes & Solier) against carbon tetrachloride induced kidney injury in Wistar rats. Asia Pacific J Tropic Dis. 2012;2(1):S435-41. doi: 10.1016/S2222-1808(12)60199-6.
  • 27. Mossanen JC, Tacke F. Acetaminophen-induced acute liver injury in mice. Laboratory Anim. 2015;49(1_suppl):30-6. doi: 10.1177/0023677215570992.
  • 28. Nithianantham K, Shyamala M, Chen Y, Latha LY, Jothy SL, Sasidharan S. Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice. Molecules. 2011;16(12):10134-45. doi: 10.3390/molecules161210134. [PubMed: 22146374]. [PubMed Central: PMC6264671].
  • 29. Sener G, Sehirli AO, Ayanoglu-Dulger G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: A comparative study. J Pineal Res. 2003;35(1):61-8. doi: 10.1034/j.1600-079X.2003.00050.x. [PubMed: 12823615].
  • 30. Yapar K, Kart A, Karapehlivan M, Atakisi O, Tunca R, Erginsoy S, et al. Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. Exp Toxicol Pathol. 2007;59(2):121-8. doi: 10.1016/j.etp.2007.02.009. [PubMed: 17716880].
  • 31. Crowley LV. The Reitman-Frankel colorimetric transaminase procedure in suspected myocardial infarction. Clin Chem. 1967;13(6):482-7. [PubMed: 6027778].
  • 32. Bowers GN, McComb RB. Measurement of total alkaline phosphatase activity in human serum. Clin Chem. 1975;21(13):1988-95.
  • 33. Fischer AH, Jacobson KA, Rose J, Zeller R. Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc. 2008;2008:pdb prot4986. doi: 10.1101/pdb.prot4986. [PubMed: 21356829].
  • 34. Armitage P, Berry G, Matthews JNS. Statistical methods in medical research. John Wiley & Sons; 2008.
  • 35. Raghavendran HRB, Sathivel A, Devaki T. Hepatoprotective nature of seaweed alcoholic extract on acetaminophen induced hepatic oxidative stress. J Health Sci. 2004;50(1):42-6. doi: 10.1248/jhs.50.42.
  • 36. Yang X, Kang MC, Lee KW, Kang SM, Lee WW, Jeon YJ. Antioxidant activity and cell protective effect of loliolide isolated from Sargassum ringgoldianum subsp. coreanum. Algae. 2011;26(2):201-8. doi: 10.4490/algae.2011.26.2.201.
  • 37. Daisy A, Indra V, Geetha S, Seetharaman S, Selvamuthu B. Phytochemical profiling of seaweeds collected from Pulicat lake, Coramandal coast of south India. World J Pharm Pharm Sci. 2016;5(7):1292-7.
  • 38. Bhaigyabati T, Kirithika T, Shiny K, Usha K. Phytochemical screening and antioxidant activity of various extracts of Sargassum muticum. Int J Pharm Res Dev. 2011;3(10):25-30.
  • 39. Bambang BS, Kumalaningsih S, Susinggih W, Hardoko . Polyphenol content and antioxidant activities of crude extract from brown algae by various solvents. J Life Sci Biomed. 2013;3(6):439-43.
  • 40. Jin W, Zhang W, Wang J, Yao J, Xie E, Liu D, et al. A study of neuroprotective and antioxidant activities of heteropolysaccharides from six Sargassum species. Int J Biol Macromol. 2014;67:336-42. doi: 10.1016/j.ijbiomac.2014.03.031. [PubMed: 24680812].

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