Jundishapur Journal of Natural Pharmaceutical Products

Published by: Kowsar

Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats

Stepan Sergeevich Dzhimak 1 , 2 , * , Alla Ivanovna Shikhliarova 3 , Galina Vitalievna Zhukova 3 , Alexandr Alexandrovich Basov 2 , 4 , Oleg Ivanovich Kit 3 , Liliya Viacheslavovna Fedulova 1 , Tatiana Anatolievna Kurkina 3 , Elena Alekseevna Shirnina 3 , Tatiana Panteleevna Protasova 3 , Mikhail Gennadievich Baryshev 2 and Alexandr Alekseevich Timakov 5
Authors Information
1 Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia
2 Department of Radiophysics and Nanotechnology, Kuban State University, Krasnodar, Russia
3 Testing Laboratory Centre, Rostov Research Institute of Oncology, Rostov-on-Don, Russia
4 Department of Fundamental and Clinical Biochemistry, Kuban State Medical University, Krasnodar, Russia
5 MTK Iceberg, LLC, Moscow, Russia
Article information
  • Jundishapur Journal of Natural Pharmaceutical Products: August 2018, 13 (3); e83494
  • Published Online: August 28, 2018
  • Article Type: Research Article
  • Received: February 9, 2017
  • Accepted: April 22, 2018
  • DOI: 10.5812/jjnpp.83494

To Cite: Dzhimak S S, Shikhliarova A I, Zhukova G V, Basov A A, Kit O I, et al. Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats, Jundishapur J Nat Pharm Prod. 2018 ; 13(3):e83494. doi: 10.5812/jjnpp.83494.

Copyright © 2018, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Dil'man VM, Dean W. The neuroendocrine theory of aging and degenerative disease. Center for Bio Gerontology; 1992.
  • 2. Rowinski R, Kozakiewicz M, Kedziora-Kornatowska K, Hubner-Wozniak E, Kedziora J. Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity. Exp Gerontol. 2013;48(11):1141-6. doi: 10.1016/j.exger.2013.07.010. [PubMed: 23911531].
  • 3. Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013;13(12):875-87. doi: 10.1038/nri3547. [PubMed: 24157572]. [PubMed Central: PMC4096436].
  • 4. Dzhimak SS, Basov AA, Baryshev MG. Content of deuterium in biological fluids and organs: influence of deuterium depleted water on D/H gradient and the process of adaptation. Dokl Biochem Biophys. 2015;465:370-3. doi: 10.1134/S1607672915060071. [PubMed: 26728727].
  • 5. Kreuzer-Martin HW, Lott MJ, Ehleringer JR, Hegg EL. Metabolic processes account for the majority of the intracellular water in log-phase Escherichia coli cells as revealed by hydrogen isotopes. Biochemistry. 2006;45(45):13622-30. doi: 10.1021/bi0609164. [PubMed: 17087516].
  • 6. Soto DX, Hobson KA, Wassenaar LI. The influence of metabolic effects on stable hydrogen isotopes in tissues of aquatic organisms. Isotopes Environ Health Stud. 2013;49(3):305-11. doi: 10.1080/10256016.2013.820727. [PubMed: 23947759].
  • 7. Strekalova T, Evans M, Chernopiatko A, Couch Y, Costa-Nunes J, Cespuglio R, et al. Deuterium content of water increases depression susceptibility: the potential role of a serotonin-related mechanism. Behav Brain Res. 2015;277:237-44. doi: 10.1016/j.bbr.2014.07.039. [PubMed: 25092571].
  • 8. Basov AA, Bykov IM, Baryshev MG, Dzhimak SS, Bykov MI. [Determination of deuterium concentration in foods and influence of water with modified isotopic composition on oxidation parameters and heavy hydrogen isotopes content in experimental animals]. Vopr Pitan. 2014;83(5):43-50. Russian. [PubMed: 25816625].
  • 9. Basov AA, Bykov IM, Fedulova LV, Dzhimak SS, Baryshev MG. Correction of oxidative m etabolism in blood and tissues of the internal organs in laboratory animals using isotopic D/H exchange reactions. Med news North Caucasus. 2016;11(1). doi: 10.14300/mnnc.2016.11010.
  • 10. Avila DS, Somlyai G, Somlyai I, Aschner M. Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model. Toxicol Lett. 2012;211(3):319-24. doi: 10.1016/j.toxlet.2012.04.014. [PubMed: 22561170]. [PubMed Central: PMC4917383].
  • 11. Lisitsyn AB, Baryshev MG, Basov AA, Barysheva EV, Bykov IM, Dydykin AS, et al. [Influence of deuterium depleted water on the organism of laboratory animals in various functional conditions of nonspecific protective systems]. Biofizika. 2014;59(4):757-65. Russian. [PubMed: 25707244].
  • 12. Somlyai G, Jancso G, Jakli G, Vass K, Barna B, Lakics V, et al. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Lett. 1993;317(1-2):1-4. [PubMed: 8428617].
  • 13. Cong FS, Zhang YR, Sheng HC, Ao ZH, Zhang SY, Wang JY. Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis. Exp Ther Med. 2010;1(2):277-83. doi: 10.3892/etm_00000043. [PubMed: 22993540]. [PubMed Central: PMC3445928].
  • 14. Anisimov VN. Biology of aging and cancer. Cancer Control. 2007;14(1):23-31. doi: 10.1177/107327480701400104. [PubMed: 17242668].
  • 15. Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007;448(7155):767-74. doi: 10.1038/nature05985. [PubMed: 17700693].
  • 16. Griffiths TR. A new unifying theory for the initiation of ageing mechanisms and processes. Mech Ageing Dev. 1973;2(4):295-307. doi: 10.1016/0047-6374(73)90024-9. [PubMed: 4778851].
  • 17. Seal RR, Shanks WC. Oxygen and hydrogen isotope systematics of lake Baikal, Siberia: Implications for paleoclimate studies. Limnol Oceanograph. 1998;43(6):1251-61. doi: 10.4319/lo.1998.43.6.1251.
  • 18. Zamana LV. Isotopes of hydrogen and oxygen in nitrogen hot springs of Baikal Rift Zone in terms of interaction in the water-rock system. Doklady Earth Sci. 2012;442(1):81-5. doi: 10.1134/s1028334x12010114.
  • 19. Bykov MI, Dzhimak SS, Basov AA, Arcybasheva OM, Shashkov D, Baryshev MG. [Comparative characteristics of the isotopic D/H composition and antioxidant activity of freshly squeezed juices from fruits and vegetables grown in different geographical regions]. Vopr Pitan. 2015;84(4):89-96. Russian. [PubMed: 26852536].
  • 20. Koziet J, Rossmann A, Martin GJ, Johnson P. Determination of the oxygen-18 and deuterium content of fruit and vegetable juice water. An European inter-laboratory comparison study. Analytica Chimica Acta. 1995;302(1):29-37. doi: 10.1016/0003-2670(94)00424-k.
  • 21. Marcondes FK, Bianchi FJ, Tanno AP. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol. 2002;62(4A):609-14. [PubMed: 12659010].
  • 22. Dzhimak SS, Basov AA, Kopytov GF, Kashaev DV, Sokolov ME, Artsybasheva OM, et al. Application of NMR spectroscopy to the determination of low concentrations of nonradioactive isotopes in liquid media. Russ Physics J. 2015;58(7):923-9. doi: 10.1007/s11182-015-0591-9.
  • 23. Dzhimak SS, Baryshev MG, Basov AA, Timakov AA. [Influence of deuterium depleted water on freeze-dried tissue isotopic composition and morphofunctional body performance in rats of different generations]. Biophysics. 2014;59(4):614-9. Russian. doi: 10.1134/S0006350914040101.
  • 24. Siniak Iu E, Grigor'ev AI, Skuratov VM, Ivanova SM, Pokrovskii BG. [Fractionation of hydrogen stable isotopes in the human body]. Aviakosm Ekolog Med. 2006;40(5):38-41. Russian. [PubMed: 17357626].
  • 25. Dzhimak SS, Basov AA, Fedulova LV, Didikin AS, Bikov IM, Arcybasheva OM, et al. [Correction of metabolic processes in rats during chronic endotoxicosis using isotope (D/H) exchange reactions]. Biol Bull. 2015;(5):440-8. Russian. doi: 10.1134/S1062359015050064.
  • 26. Hayes JM. Fractionation of carbon and hydrogen isotopes in biosynthetic processes. Rev Mineral Geochem. 2001;43(1):225-77. doi: 10.2138/gsrmg.43.1.225.
  • 27. Schmidt HL, Kexel H. Metabolite pools and metabolic branching as factors of in-vivo isotope discriminations by kinetic isotope effects. Isotopes Environ Health Stud. 1997;33(1-2):19-30. doi: 10.1080/10256019708036328. [PubMed: 22087478].
  • 28. Schmidt HL, Robins RJ, Werner RA. Multi-factorial in vivo stable isotope fractionation: causes, correlations, consequences and applications. Isotopes Environ Health Stud. 2015;51(1):155-99. doi: 10.1080/10256016.2015.1014355. [PubMed: 25894429].
  • 29. Mashina S, Smirin BV, Malyshev I, Liamina NP, Senchikhin VN, Pokidyshev DA, et al. [Correction of NO-dependent cardiovascular disorders by adaptation to hypoxia]. Ross Fiziol Zh Im I M Sechenova. 2001;87(1):110-7. Russian. [PubMed: 11227854].
  • 30. Miller BH, Takahashi JS. Central circadian control of female reproductive function. Front endocrinol. 2014;4:195.

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments