Biological plasma-derived medicines play an important role in the treatment and also prevention of many diseases. The technique implemented to produce such medicines should ensure to minimize the risk of pathogen infection. A very crucial step is the removal or inactivation of highly pathogenic plasma viruses, and ... read more

Oral administration of drugs remains the most common and preferred route for many active pharmaceutical ingredients (APIs). However, solid oral dosage forms may be limited for patients who have swallowing problems or fear of choking. Furthermore in the case of solid dosage forms, disintegration and dissolution of ... read more

The poor bioavailability of ophthalmic drops is mainly due to the rapid nasolacrimal drainage of the drug and very low permeability of corneal epithelium. Hence, there is an interest to find an effective system to improve drug permeability and bioavailability.The aim of the present study was to ... read more

This study aimed to screen Thais savignyi whole body extracts for antibacterial activity against clinical isolates of some human pathogenic bacteria and analyze its biochemical compounds, including carbohydrate, proteins, alkaloids, cholesterol, unsaturated fatty acids, as well as functional groups and elements.Well agar diffusion was used for screening ... read more

Analgesics such as opioids are commonly used for pain control in emergency departments. correlated respiratory side effects and central nervous system depression confine opioids application as analgesic medication. New pain control choices such as Nitric oxide and Ketamine may be alternatives. This study evaluates efficacy of Nitric ... read more

Crocin, an active ingredient of saffron, has been found to possess hypotensive effects.The aim of this study was to evaluate the mechanism of vasodilatory effects induced by crocin on isolated rat aorta.To study the vasodilatory effects of crocin (0.1, 0.2, 0.4 and 0.8 M), isolated rat thoracic ... read more

The medicinal herb Tribulus terrestris L. (Zygophyllaceae) has been used for a long time to treat various kinds of diseases including hepatocellular carcinoma.The aim of the present study was to investigate the anticancer activity of hydroalcoholic extract of T. terrestris fruit on prostate and colon cancerous cell ... read more

It is shown that the premenstrual syndrome is related to a plethora of problems due to its direct and indirect effects on work, school, home, and productivity or inefficiency of relationships with others.A double-blind, randomized controlled clinical trial (RCTs) was conducted in gynecology clinic of Zeinabieh Hospital ... read more

Albendazole (ABZ) and albendazole sulfoxide (ABZSO) have a basic role in the treatment of hydatid cysts. However, their poor solubility and limited intestinal permeability are the main problems in their formulation.The preparation and characterization of ABZ and ABZSO-loaded solid lipid nanoparticles (SLNs) to increase the hydatid cyst ... read more

Epilepsy is a group of disorders associated with the abnormal electrical activity of different regions of the brain. The use of anticonvulsant drugs is limited because of their low efficacy, side effects, and toxicity. Therefore, research on new drugs for epilepsy is required. Meloxicam is a non-steroidal ... read more

This study was conducted to investigate in vitro, methanolic extract and methanol/water fractions obtained from the arial parts of Artemisia spicigera C. Koch (Asteraceae family) and for evaluation of their antiproliferative effects against HT-29, L-929 and A 549 cell lines by MTT assay at different concentrations (1, ... read more

Cervical cancer is the second most common cancer in women. Several native Iranian herbs used in traditional medicine are proven to have cytotoxic effects.The present study was designed to compare the anticancer effects of three medicinal herbs, Peganum harmala L., Curcuma longa L., and Boswellia serrata, on ... read more

There are verities of none-prescribed slimming products available in the markets which are not approved by the FDA. Hence, different kind of problem has accrued and many complications are unresolved, and an individual healthy is exposed to risks. In this case, although all measures were taken to ... read more