Quercetin Preventive Effects on Theophylline-Induced Anomalies in Rat Embryo

AUTHORS

Neda Sistani Karampour 1 , * , Ardeshir Arzi 2 , Hossein Najafzadeh Varzi 3 , Babak Mohammadian 4 , Mohsen Rezaei 1

1 Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran

2 Department of Pharmacology and Toxicology, Physiology Research Center, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran

3 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamram University, Ahvaz, IR Iran

4 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamram University, Ahvaz, IR Iran

How to Cite: Sistani Karampour N, Arzi A, Najafzadeh Varzi H, Mohammadian B, Rezaei M. Quercetin Preventive Effects on Theophylline-Induced Anomalies in Rat Embryo, Jundishapur J Nat Pharm Prod. 2014 ; 9(3):17834. doi: 10.17795/jjnpp-17834.

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 9 (3); 17834
Published Online: July 31, 2014
Article Type: Research Article
Received: January 25, 2014
Accepted: February 22, 2014
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Abstract

Background: Theophylline has been shown to cause heart anomaly in animal and human fetus.

Objectives: The present study aimed to investigate the protective effect of quercetin on theophylline-induced heart disorders in rat embryo.

Materials and Methods: Theophylline-induced teratogenicity in rats was used as the animal model. Pregnant rats were administered theophylline (259 mg/kg, po) or theophylline plus quercetin (259 mg/kg, po and 100 mg/kg, ip, respectively) on 9th and 10th days of pregnancy. On day 19, cardiac changes were assessed, measuring malondialdehyde (MDA) and glutathione peroxidase (GPx) activity levels in blood samples and also the fetus heart weight. Histopathological examination was also performed on all specimens.

Results: Theophylline-treated rats showed MDA level elevation and GPx activity reduction. Quercetin treatment improved heart conditions and resulted in a significant reduction in MDA levels and elevation in GPx activity. Moreover, co-administration of quercetin and theophylline increased the heart weight significantly. Furthermore, histophatological study showed no changes in the treated groups.

Conclusions: This study demonstrated that quercetin have beneficial effects on theophylline-induced-anomalies in rat embryo.

Keywords

Theophylline Quercetin Malondialdehyde Glutathione peroxidase

© 2014, Jundishapur Journal of Natural Pharmaceutical Products. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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